Dr. Eduardo de Pablo-Fernández and Dr Tommaso Schirinzi discuss the results of his study evaluating markers of immune response, metabolism, inflammatory regulation and tau levels in blood cells in patients with progressive supranuclear palsy (PSP). They also discuss how these results contribute to the growing evidence of neuroinflammation contributing to the pathogenesis of PSP.

Journal CME is available until October 21, 2025

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Dr. Shiro Horisawa discusses the latest clinical trial results on MR-guided focused ultrasound pallidothalamic tractotomy for cervical dystonia. He explores the technique's limitations, future prospects, and how it compares to existing therapeutic options.

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Dr. Hugo Morales Briceno interviews Prof. Ray Chaudhuri to discuss the real world-use of levodopa subcutaneous infusion in patients with Parkinson's disease.

Dr. Chan joins the podcast to discuss the results of their pilot study with Dr. Eduardo De Pablo-Fernández. The study uses a foot vibrotactile stimulation as an external cue for the treatment of freezing of gait in Parkinson's disease. Together they discuss how vibrotactile devices can be implemented in clinical practice.

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In this episode, Prof. Alexander Münchau talks about how machine learning video-based assessments can be leveraged to quantify tics in Tourette syndrome and how this technology has the potential to assist clinicians in tic detection.

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In this episode, Dr. Aasef Shaikh and Dr. Ming-Kai Pan give us a virtual guided tour of their labs, particularly discussing what they are presently working on. They further elaborate on how these studies can inform our understanding of tremor physiology and where they believe the field should be heading in order to finally understand tremor origin.

Dr. Michele Matarazzo interviews Dr. Victor Fung, President of the International Parkinson and Movement Disorder Society and lead author of the recent viewpoint published in the Movement Disorders journal. Together, they explore the biological definition and classification of Parkinson's disease, discussing its key insights, future prospects, and the implications of recent advances in the field.

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In this episode Dr. Ludy Shih briefly describes the current approach to tremor, including pharmacological treatments, botulinum toxin injections and deep brain stimulation. She further dives into the exciting new developments of the past few years and new drugs coming down the pipeline.

In this episode, the two souls at the center of the new tremor classification join the MDS Podcast to discuss what essential tremor is. Listen as Prof. Kailash Bhatia and Prof. Günther Deuschl walk you through their clinical methods and future outlook on essential tremor. Do they agree? Disagree?

Growing evidence suggests a contributory role of tau protein in the pathogenesis of Huntington's disease. In this episode, Dr. Eduardo de Pablo-Fernández discusses the potential role of skin tau quantification as a biomarker for Huntington's disease with Dr. Jaime Kulisevsky and Dr. Iñigo Ruiz-Barrio. The authors discuss the results of the recent study correlating skin tau quantification with clinical and radiological data, and the role of skin tau in defining HD subtypes.

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