Modern Healthspan

Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen

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Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.

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Pendulum 20% discount with code HEALTHSPAN

Akkermansia https://www.dpbolvw.net/click-100875787-15048681

Glucose Control https://www.tkqlhce.com/click-100875787-15009432

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We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia.

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Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

Pendulum 20% discount with code HEALTHSPAN

Akkermansia https://www.dpbolvw.net/click-100875787-15048681

Glucose Control https://www.tkqlhce.com/click-100875787-15009432

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com

We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in

Some links are affiliate links so we will earn a commission when they are used to purchase products.

🌐Links in this video

Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

Pendulum 20% discount with code HEALTHSPAN

Akkermansia https://www.dpbolvw.net/click-100875787-15048681

Glucose Control https://www.tkqlhce.com/click-100875787-15009432

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging ⁠https://www.science.org/doi/10.1126/science.adi3025⁠

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The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans.

🌐Links in this video

The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about how the NAD precursors are absorbed when administered in different formats and what is seen in the biochemistry after that. And some really weird interaction between mammals and bacteria with nicotinamide/nicotinic acid in the gut.

🌐Links in this video

The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about results from trials of NAD boosters in mice and human trials and possible reasons for why the positive results in mice have not translated to humans.

🌐Links in this video

The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about how NAD metabolism changes with age, especially the role of NAMPT, the consuming enzymes and NAD boosters.

🌐Links in this video

The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about the evidence of NAD decline with age and how it can be restored with exercise. We also touch on NAD/NADH ratio.

Some links are affiliate links so we will earn a commission when they are used to purchase products.

🌐Links in this video

The Baur Lab website https://www.med.upenn.edu/baurlab/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Vijay Yadav about his planned next steps for interventional human trials and what doses he will try.

Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.

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Dr Yadav on Linkedin https://www.linkedin.com/in/drvijaykyadav

Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/