Modern Healthspan

Here Dr Conlon explains the biochemistry behind Nuchido Time+ and how it activates the salvage pathway through NAMPT to replenish cellular NAD in sustainable way.

Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan.

Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate and support the wider population, encouraging people to age well and achieve their optimal life experience.

🌐Links in this video

Nuchido website https://nuchido.com/

Dr Conlon's Instagram https://www.instagram.com/drnicholaconlon/ (@drnicholaconlon)

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans.

Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat

🌐Links in this video

Dr Gorbunova's website

https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/

Sirtuin 6: linking longevity with genome and epigenome stability.

https://pubmed.ncbi.nlm.nih.gov/34281779/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Professor Gorbunova talks about hyaluronic acid, what it is and why it is different in naked mole rats. She also talks about a trial that she performed where the gene for HA was placed in mice. Finally we talk about how this could be translated into clinical usage.

Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat

🌐Links in this video

Dr Gorbunova's website

https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/

Sirtuin 6: linking longevity with genome and epigenome stability.

https://pubmed.ncbi.nlm.nih.gov/34281779/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Professor Gorbunova talks about the two functions of SIRT6, deacetylation and ribosylation, the importance of them and how they can be activated. She also touches on chromatin remodeling and Yamanaka factors.

Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat

🌐Links in this video

Dr Gorbunova's website

https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/

Sirtuin 6: linking longevity with genome and epigenome stability.

https://pubmed.ncbi.nlm.nih.gov/34281779/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Professor Gorbunova talks about the key activities of SIRT6 that are involved with longevity, particularly DNA repair and the suppression of transposons.

Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat

🌐Links in this video

Dr Gorbunova's website

https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/

Sirtuin 6: linking longevity with genome and epigenome stability.

https://pubmed.ncbi.nlm.nih.gov/34281779/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

In this video Dr Wang talks about the current state of trials and how the therapy might eventually look.

Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambridge and his M.D. from Columbia University. He was a postdoctoral fellow in cell and gene therapy with George Church at Harvard Medical School.

🌐Links in this video

Thymmune Therapeutics https://www.thymmune.com/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

In this episode Dr Wang explains about the thymus gland and his technology for not only restoring the thymus but building new thymuses from iPCSs at scale.

Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambridge and his M.D. from Columbia University. He was a postdoctoral fellow in cell and gene therapy with George Church at Harvard Medical School.

🌐Links in this video

Thymmune Therapeutics https://www.thymmune.com/

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Dr Tan talks about tocotrienols in bone health, what an appropriate dosage is and it is better not to take alpha tocopherol with the tocotrienols.

Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.

For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!

🌐Links in this video

American River Nutrition https://americanrivernutrition.com/

Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/

You can download with the code Modern Healthspan

δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial

https://www.liebertpub.com/doi/10.1089/met.2022.0052

GG Article

https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Dr Tan talks about the trails that have been run on tocotrienols and the results that have been seen. They have beneficial effects on a number of the markers of metabolic syndrome, such as the lipid panel and liver fat.

Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.

For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!

🌐Links in this video

American River Nutrition https://americanrivernutrition.com/

Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/

You can download with the code Modern Healthspan

δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial

https://www.liebertpub.com/doi/10.1089/met.2022.0052

GG Article

https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Dr Tan introduces the forms of vitamin E, how they are different and why this matters. He also discusses why a fat based anti-oxidant is required and where alpha tocotrienol is found in nature.

Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.

For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!

American River Nutrition https://americanrivernutrition.com/

Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/

You can download with the code Modern Healthspan

δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial

https://www.liebertpub.com/doi/10.1089/met.2022.0052

GG Article

https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg

Catch us on YouTube: https://www.youtube.com/c/modernhealthspan

10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5

10% off DoNotAge all products with discount code MHS https://donotage.org/products/

ProHealth 15% of all products Code MODERN: https://www.prohealth.com/