In Episode 5 Dr. Lithgow talks about the different forms of AKG and why  they chose to go with CaAKG. He also touches on the difficulty in doing  the kind of head to head studies that would be able to see if either was  more effective.  

Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.  

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In Episode 4 Dr. Lithgow talks about , some other potential benefits of AKG rather than extend healthspan and lifespan.  

Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.  

*********************************************************************************** If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan

In Episode 3 Dr. Lithgow introduces AKG, or Alpha Ketoglutarate and talks about a recent trial that they did with mice. In the trial they  saw both increased lifespan and healthspan, mostly in the female mice. 

Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the  Tenovus Award for Biomedical Research.

In the talk Dr. Lithgow discusses the current drugs that are available  along with some of the limitations of the studies that we are currently  doing.   

Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the  Tenovus Award for Biomedical Research.  *********************************************************************************** 

If you would like to support our channel, we’d love a coffee…thank you!  https://www.buymeacoffee.com/mhealthspan

In Episode 1 Dr. Lithgow talks about his journey to study aging, his  thoughts on why we age and whether there is limit to the age that humans  can live to.   

Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.

In this video Dr. Sabatini discusses some of the life style interventions that affect our longevity and his personal regimen. This  is the last episode of Dr. Sabatani Interview Series.  

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction 

https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini 

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. 

He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

In this video Dr. Sabatini discusses how diet effects mTOR activation.  He also talks about calorie restriction and intermittent fasting.  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

In this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1  and mTORC2 and the rapalogs, drugs which are similar to rapamycin but  may be more clinically effective.   

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini 

https://www.youtube.com/watch?v=EnIerDljc7g

https://www.youtube.com/watch?v=defOfBEuw_M 

https://www.youtube.com/watch?v=tGA9RALG66s

In this video Dr. Sabatini discusses his recent paper and in particular  how the health of the mitochondria impact the activation of mTOR and how  this is signaled. 

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  Some key references. 

The paper discussed in the video.  Genome-wide CRISPR screens reveal multitiered mechanisms through which  mTORC1 senses mitochondrial dysfunction 

https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism In this video Dr. Sabatini discusses how mTOR impacts lifespan and  whether its actions change with age  

Some key references. 

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini https://www.youtube.com/watch?v=EnIerDljc7g https://www.youtube.com/watch?v=defOfBEuw_M https://www.youtube.com/watch?v=tGA9RALG66s