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RO TOOLS TO HELP YOU:
Ro Body: ro.co/otp
#ReportTheShortage - ro.co/supply-tracker
#OptInForObesity - See if you're covered ro.co/checker

Madison Muller Article on Zepbound Vial Pricing:
https://www.bloomberg.com/news/articles/2024-08-27/eli-lilly-is-now-selling-zepbound-weight-loss-drug-at-50-discount?srnd=undefined

Search Zepbound Pricing:
https://www.goodrx.com/zepbound/what-is

Empoloyer Form Letter to Add Obesity Coverage:
https://www.onthepen.com/post/optinforobesity-how-petitioning-your-employer-can-break-the-barriers-to-obesity-treatment

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Semaglutide in Parkinsons and Opiod Abuse
https://www.wired.com/story/the-benefits-of-ozempic-are-multiplying/?

How Roche Passed on Orforglipron
https://www.swissinfo.ch/eng/multinational-companies/how-roche-passed-on-a-potential-14bn-a-year-weight-loss-pill/86877239?fbclid=IwZXh0bgNhZW0CMTEAAR1doDlsWIFXuUJYA9Kz75D9VvzZycgqm2kVbVPuWWFgOP0tvOVNvIWluVY_aem_GDMhnl8sQEVePWYy0XdheQ

Roche's Obesity Pipeline
https://www.onthepen.com/post/more-threats-to-lilly-s-tirzepatide-printing-press

Novo Announced Additional API Site
https://www.fiercepharma.com/pharma/novo-create-50-jobs-new-220m-raw-ingredients-plant-will-support-ozempic-and-wegovy

Patients Splitting Pens
https://www.theatlantic.com/health/archive/2024/08/ozempic-hackers/679464/

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#ReleaseTheVials
https://www.onthepen.com/post/eli-lilly-to-releasethevials-of-zepbound
Eli Lilly has released single-dose vials for ZepBound to stabilize higher dose supplies and removed all Mounjaro and ZepBound doses from the FDA shortage list, though tirzepatide remains in shortage. Novo Nordisk is seeking FDA approval for Icosema, a combination of insulin and semaglutide, with a favorable safety profile.

Lilly Sends Tirzepatide Compound Cease and Desist Letters
https://www.onthepen.com/post/it-begins-eli-lilly-fires-off-round-of-cease-and-desist-letters-to-tirzepatide-peddlers

Eli Lilly is taking legal action against GLP-1 compounders, particularly targeting ZepBound. Cease and desist letters have been issued to smaller prescribers and med spas, potentially pressuring the FDA on tirzepatide’s shortage status.

#ReportTheShortage
Ro.co/supply-tracker

Patients are encouraged to report ZepBound or Mounjaro shortages to the FDA. Ro has introduced a supply tracker tool to notify patients of nearby availability and launched RoBody, a program connecting patients with doctors to manage obesity and achieve significant weight loss.

Insurance Checker Toll
Ro.co/checker

Ro's new GLP-1 Insurance Coverage Checker allows users to check insurance coverage for obesity medications and is integrated with the supply tracker. Despite financial struggles, 23andMe is launching a GLP-1 telehealth service. The ‘Opt-in for Obesity’ campaign encourages employees to request obesity coverage from their employers.

On The Pen Live

Z Reitano from Ro will discuss the GLP-1 Insurance Coverage Tool on the upcoming On The Pen Live session, airing on YouTube this Thursday at 9 p.m. Central.

#OptInForObesity

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Fortune interview:

• https://fortune.com/2024/08/02/eli-lilly-mounjaro-zepbound-weight-loss-ceo-alzheimers-drug/

Tirzepatide shortages (viral tiktok video with 199,000+ views):

• https://www.onthepen.com/post/zepbound-and-mounjaro-shortages-are-over-what-this-means-for-compounds
• https://cdernextgenportal.fda.gov/publicportal/s/dsm-submission
• https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-says-all-doses-lillys-weight-loss-diabetes-drug-now-available-2024-08-02/
• https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c
• https://www.pharmacytimes.com/view/updates-on-503a-compounding-the-impact-of-drug-shortages

Tirzepatide heart trial (viral tiktok video with 90,000+ views)

• https://www.onthepen.com/post/zepbound-s-cardiovascular-benefits-and-the-future-of-medicare-coverage

semaglutide pre-diabetes trial:

• https://www.sciencedirect.com/science/article/abs/pii/S2213858724001827

Weight Watchers:

• https://www.bloomberg.com/news/articles/2024-08-01/weightwatchers-to-cut-jobs-spending-as-bu

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

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Book Email Alerts: https://www.onthepen.com/glp1-book
Altimmune

• https://ir.altimmune.com/news-releases/news-release-details/altimmune-announces-publication-clinical-study-pemvidutide

Novo Nordisk Expansion:

• https://www.fiercepharma.com/pharma/amid-wegovy-and-ozempic-boom-novo-eyes-new-facility-200-acre-land-buy-denmark

Novo Nordisk Fire:

• https://www.thelocal.dk/20240724/danish-emergency-services-put-out-minor-fire-at-novo-nordisk

Novo Nordisk EU Wegovy:

• EU agreed to label expansion for Wegovy to reduce heart attack risks
• https://www.morningstar.com/news/dow-jones/2024072511614/novo-nordisks-wegovy-gets-eu-regulator-endorsement-to-reduce-heart-risks-update

Roche:

• https://www.reuters.com/business/healthcare-pharmaceuticals/roche-fast-track-weight-loss-pill-compete-with-rivals-ft-reports-2024-07-29/
• https://www.onthepen.com/post/more-threats-to-lilly-s-tirzepatide-printing-pressWeight Watchers:

Weight Watchers Resignation:

• (Madison Muller) https://www.bloomberg.com/news/articles/2024-07-25/weightwatchers-chief-medical-officer-leaves-after-less-than-year

FDA and compounding:

• https://www.politico.com/newsletters/prescription-pulse/2024/07/26/compounding-the-glp-1-craze-00171314

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On The GLP-1 Pen Book Alerts:
https://onthepen.com/emails

Gan & Lee (China)
https://www.prnewswire.com/news-releases/gan--lee-pharmaceuticals-bi-weekly-twice-a-month-glp-1-receptor-agonist-gzr18-injection-achieved-17-29-weight-loss-at-30-weeks-in-a-phase-iib-clinical-trial-302202575.html

Mazdutide (China):
https://www.fiercebiotech.com/biotech/innovent-bags-another-phase-3-win-next-gen-lilly-glp-1-drug

China:
https://www.reuters.com/business/healthcare-pharmaceuticals/eli-lillys-weight-loss-drug-tirzepatide-gets-approval-china-2024-07-19/

Retatrutide (tiktok video):
https://www.nature.com/articles/s41421-024-00700-0

GLP-1 Temperature Monitor:
https://www.varcode.com

Eli Lilly:
https://www.bioprocessonline.com/doc/how-eli-lilly-s-making-peptides-faster-and-more-reliably-0001

Support the show

Our Book Has Been Released!
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PBM reform in Illinois (tiktok video)

• https://x.com/ManOnMounjaro/status/1812833885375332394

FTC on PBM

• https://www.ftc.gov/system/files/ftc_gov/pdf/pharmacy-benefit-managers-staff-report.pdf
• https://www.ftc.gov/news-events/news/press-releases/2024/07/ftc-releases-interim-staff-report-prescription-drug-middlemen

FDA and social media (tiktok video)

• https://news.bloomberglaw.com/health-law-and-business/drug-device-online-misinformation-gets-fda-look-after-10-years

Patient weight-loss expectations

• https://www.endocrinepractice.org/article/S1530-891X(24)00564-0/abstract

Wegovy commercial:

• https://www.business2community.com/business-news/ozempic-wegovy-maker-novo-nordisk-spends-record-42-m-to-promote-the-drugs-on-tv-is-it-working-02813548

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Dave chats with world renowned obesity expert who consults for the likes of Novo Nordisk!

Beverly Tchang, MD is a triple board-certified physician  with a focus on obesity medicine. Since 2018, she has been treating patients and training professionals in endocrinology and obesity. Her nationally recognized expertise has led her to extend her knowledge and experience as an advisor to  companies, entrepreneurs, and investors who  want to learn about modern weight management. 
BeverlyTchangMD.com
X: @bevTchangMD

ro.co/OTP

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Ozempic reduces cancer risk:

• https://www.bloomberg.com/news/articles/2024-07-05/ozempic-may-lower-risk-of-obesity-related-cancers-study-finds

Semaglutide correlated with blindness (tiktok video):

• https://www.statnews.com/2024/07/03/ozempic-wegovy-naion-vision-loss-study

15-years as type-2 diabetic results in a 78% chance of have some degree of retinal eye damage

• https://www.webmd.com/diabetes/closer-look-diabetic-retinopathy

Update to Mounjaro/ZepBound FDA shortage on 7/2/2024 (tiktok video)
#releasethevials

• https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

Mounjaro KwikPen coming to Australia

• News provided by Mimi from Australia (Mimi featured in Live #61 -- part of Retatrutide trials

GIP scientific study:

• https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16478

semaglutide vs. tirzepatide

•  https://www.nbcnews.com/health/health-news/zepbound-outperforms-ozempic-wegovy-head-head-weight-loss-study-rcna160630

Keto diet:

• https://www.biorxiv.org/content/10.1101/2024.06.14.599117v1

High-price of GLP-1 medications:

• https://www.usatoday.com/story/opinion/2024/07/02/biden-sanders-prescription-drug-cost-ozempic-wegovy/74232827007/?tbref=hp

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Get OTP Emails: https://www.onthepen.com/emails

Eli Lilly

• Eli Lilly sent cease and desist letters to providers of research grade GLP-1s
• Exclusive news from onthepen.com that has not been covered by any other source
• https://www.onthepen.com/post/generic-versions-of-zepbound-how-recent-news-affects-their-future

Him & Hers:

• Him & Hers giving GLP medications without consulting with a doctor
• https://hntrbrk.com/hims/

Price for generic liraglutide/Victoza (multiple tiktok videos):

• Note: podcast last week announced generic liraglutide from Tera Pharma
• Prices as low as $225 for two pens
• https://www.goodrx.com/liraglutide?form=carton&dosage=2-pens-of-18mg-3ml&quantity=1&label_override=liraglutide

TROA

• Scaled-back TROA bill is passed out of the US House Ways and Means Committee 
• This version would limit coverage to people who had been taking a weight loss drug for a year prior to enrolling in Medicare
• https://www.nbcnews.com/health/health-news/house-committee-passes-bill-allow-medicare-cover-weight-loss-drugs-rcna159248

BI 3034701 (tiktok video):

• Boehringer Ingelheim and Gubra start phase 1 trial of BI 3034701 which is retatrutide competitor (GLP-1/GIP/glucagon)
• https://www.boehringer-ingelheim.com/science-innovation/human-health-innovation/phase-1-start-novel-triple-agonist-obesity-treatment

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Does your insurance cover GLPs? https://www.ro.com/checker

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and...