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On The GLP-1 Pen Book Alerts:
https://onthepen.com/emails

Gan & Lee (China)
https://www.prnewswire.com/news-releases/gan--lee-pharmaceuticals-bi-weekly-twice-a-month-glp-1-receptor-agonist-gzr18-injection-achieved-17-29-weight-loss-at-30-weeks-in-a-phase-iib-clinical-trial-302202575.html

Mazdutide (China):
https://www.fiercebiotech.com/biotech/innovent-bags-another-phase-3-win-next-gen-lilly-glp-1-drug

China:
https://www.reuters.com/business/healthcare-pharmaceuticals/eli-lillys-weight-loss-drug-tirzepatide-gets-approval-china-2024-07-19/

Retatrutide (tiktok video):
https://www.nature.com/articles/s41421-024-00700-0

GLP-1 Temperature Monitor:
https://www.varcode.com

Eli Lilly:
https://www.bioprocessonline.com/doc/how-eli-lilly-s-making-peptides-faster-and-more-reliably-0001

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PBM reform in Illinois (tiktok video)

• https://x.com/ManOnMounjaro/status/1812833885375332394

FTC on PBM

• https://www.ftc.gov/system/files/ftc_gov/pdf/pharmacy-benefit-managers-staff-report.pdf
• https://www.ftc.gov/news-events/news/press-releases/2024/07/ftc-releases-interim-staff-report-prescription-drug-middlemen

FDA and social media (tiktok video)

• https://news.bloomberglaw.com/health-law-and-business/drug-device-online-misinformation-gets-fda-look-after-10-years

Patient weight-loss expectations

• https://www.endocrinepractice.org/article/S1530-891X(24)00564-0/abstract

Wegovy commercial:

• https://www.business2community.com/business-news/ozempic-wegovy-maker-novo-nordisk-spends-record-42-m-to-promote-the-drugs-on-tv-is-it-working-02813548

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Dave chats with world renowned obesity expert who consults for the likes of Novo Nordisk!

Beverly Tchang, MD is a triple board-certified physician  with a focus on obesity medicine. Since 2018, she has been treating patients and training professionals in endocrinology and obesity. Her nationally recognized expertise has led her to extend her knowledge and experience as an advisor to  companies, entrepreneurs, and investors who  want to learn about modern weight management. 
BeverlyTchangMD.com
X: @bevTchangMD

ro.co/OTP

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Ozempic reduces cancer risk:

• https://www.bloomberg.com/news/articles/2024-07-05/ozempic-may-lower-risk-of-obesity-related-cancers-study-finds

Semaglutide correlated with blindness (tiktok video):

• https://www.statnews.com/2024/07/03/ozempic-wegovy-naion-vision-loss-study

15-years as type-2 diabetic results in a 78% chance of have some degree of retinal eye damage

• https://www.webmd.com/diabetes/closer-look-diabetic-retinopathy

Update to Mounjaro/ZepBound FDA shortage on 7/2/2024 (tiktok video)
#releasethevials

• https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

Mounjaro KwikPen coming to Australia

• News provided by Mimi from Australia (Mimi featured in Live #61 -- part of Retatrutide trials

GIP scientific study:

• https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16478

semaglutide vs. tirzepatide

•  https://www.nbcnews.com/health/health-news/zepbound-outperforms-ozempic-wegovy-head-head-weight-loss-study-rcna160630

Keto diet:

• https://www.biorxiv.org/content/10.1101/2024.06.14.599117v1

High-price of GLP-1 medications:

• https://www.usatoday.com/story/opinion/2024/07/02/biden-sanders-prescription-drug-cost-ozempic-wegovy/74232827007/?tbref=hp

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Get OTP Emails: https://www.onthepen.com/emails

Eli Lilly

• Eli Lilly sent cease and desist letters to providers of research grade GLP-1s
• Exclusive news from onthepen.com that has not been covered by any other source
• https://www.onthepen.com/post/generic-versions-of-zepbound-how-recent-news-affects-their-future

Him & Hers:

• Him & Hers giving GLP medications without consulting with a doctor
• https://hntrbrk.com/hims/

Price for generic liraglutide/Victoza (multiple tiktok videos):

• Note: podcast last week announced generic liraglutide from Tera Pharma
• Prices as low as $225 for two pens
• https://www.goodrx.com/liraglutide?form=carton&dosage=2-pens-of-18mg-3ml&quantity=1&label_override=liraglutide

TROA

• Scaled-back TROA bill is passed out of the US House Ways and Means Committee 
• This version would limit coverage to people who had been taking a weight loss drug for a year prior to enrolling in Medicare
• https://www.nbcnews.com/health/health-news/house-committee-passes-bill-allow-medicare-cover-weight-loss-drugs-rcna159248

BI 3034701 (tiktok video):

• Boehringer Ingelheim and Gubra start phase 1 trial of BI 3034701 which is retatrutide competitor (GLP-1/GIP/glucagon)
• https://www.boehringer-ingelheim.com/science-innovation/human-health-innovation/phase-1-start-novel-triple-agonist-obesity-treatment

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Novo Nordisk expansion in the US:
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=168528

Generic liraglutide
https://www.onthepen.com/post/teva-launches-first-ever-generic-glp-1-a-game-changer-for-diabetes-and-weight-management

New Wegovy Coupon:
https://www.wegovy.com/coverage-and-savings/save-on-wegovy.html

New Mounjaro Card (tiktok video)
https://mounjaro.lilly.com/savings-resources

Tirzepatide (tiktok video):
https://www.reuters.com/business/healthcare-pharmaceuticals/weight-loss-drug-zepbound-resolves-sleep-apnea-up-52-patients-lilly-says-2024-06-21/

Petrelintide
https://www.onthepen.com/post/introducing-petrelintide-discover-the-promise-of-amalyn-agonist-medications-for-weight-loss

Gut bacteria:

• Interesting research that shows that type-2 diabetics have more microbiome in their gut that suppresses incretin hormones like GLP-1. This is more evidence that #glp1 medications fix what is biologically broken
• https://www.onthepen.com/post/glp-1-slow-responders-gut-bacteria-may-hold-the-key

DACRA:
https://ir.vikingtherapeutics.com/2024-06-24-Viking-Therapeutics-Presents-Preclinical-

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PBM Reform Form Letter: 

• Link to the Letter: https://www.onthepen.com/post/pbm-reform-form-letter-for-elected-representatives

Express scripts (tiktok video on PBM reform):

• Link to my video: https://www.youtube.com/watch?v=l0g6RwViOxc

Michigan (tiktok video)

• Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-12/michigan-s-largest-insurer-to-drop-weight-loss-drug-coverage

Accessibility

• Link: https://www.benefitspro.com/2024/06/13/8-ways-to-use-behavioral-science-to-address-obesity/?slreturn=20240614174121

Vivani (tiktok)

• Link: https://www.businesswire.com/news/home/20240613953589/en/Vivani-Medical-Announces-FDA-Clears-Investigational-New-Drug-Application-and-Lifts-Clinical-Hold-for-NPM-119-a-Miniature-Long-Term-Subdermal-GLP-1-Drug-Implant

Diet on GLP-1:

• Link: https://www.upi.com/Health_News/2024/06/11/Ozempic-Wegovy-nutrition-requirements/4931718111093/
• Link: https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24067?domain=p2p_domain&token=ZXK7NJV6GEXBQQHGZ6TH

Online GLP-1s:

• Link: https://www.npr.org/sections/sho

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Eli Lilly's phase 2 SYNERGY-NASH study shows tirzepatide effectively resolves MASH and improves fibrosis, offering hope for millions. Read more here: https://www.onthepen.com/post/tirzepatide-shows-promise-in-treating-mash-key-findings-from-the-synergy-nash-study

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Ro.co/supply-tracker

FDA shortage update (tiktok video):
Link:https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

EASL (European Association for the Study of the Liver) 2024 in Milan Italy
Link: https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
Link: https://www.biospace.com/article/mash-clash-between-lilly-and-boehringer-zealand-takes-center-stage-at-easl24/

Walgreen:
Link: https://www.benefitspro.com/2024/06/03/walgreens-will-conduct-clinical-trials-for-boehringer-ingelheims-new-obesity-drug/?slreturn=20240610103336

Kroger (tiktok video):
Link: https://www.aol.com/news/kroger-health-revamps-weight-management-132122808.html

Eli Lilly Clinical trial:
Link: https://clinicaltrials.gov/study/NCT06373146?term=tirzepatide&aggFilters=status:act%20rec&rank=6

Eli Lilly CFO:
Link: https://www.prnewswire.com/news-releases/lilly-announces-departure-of-anat-ashkenazi-chief-financial-officer-302163882.html

China:
Link: https://www.benzinga.co

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https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k

Novo Nordisk Advertising:

• Novo Nordisk launches new advertising campaign "The Power of Wegovy"
• This advertisement includes the new indication for reduction of cardiovascular risk
• For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million.  The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic  went to online video platforms (i.e. social media like youtube)
• Link: https://www.youtube.com/watch?v=dhretLXYkZ4

Structure Therapeutics GSBR-1290

• GSBR-1290 is a small molecule GLP-1 pill
• In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
• At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
• Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
• Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure

Elon musk tweet:

• Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
• This tweet has currently been seen 325,500 times

Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy

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