The endothelium is a single layer of cells lining the inside of our blood vessels – and other internal organs. Not only is it responsible for signaling the contraction and dilation of vessels, but it controls clotting, inflammation, oxidative stress, and more! When this system breaks down, its effects are wide-reaching. Endothelial dysfunction is often the root cause of subsequent cardiovascular disease, strokes, and many chronic conditions. Because it can sometimes be reversible, understanding what causes it, how to treat it, and what you can do to prevent it becomes vital.

In today’s episode, we discuss the physiologic role of the endothelium, how it relates to atherosclerosis, and practical strategies to promote cardiovascular health.

Today on The Lab Report:

• 2:55 Defining Terms – What is the Endothelium?
• 7:10 Oxidative stress, inflammation, and drivers of endothelial dysfunction
• 11:00 How do we get to atherosclerosis?
• 14:20 Indirect causes of endothelial dysfunction
• 15:50 Direct causes and sheering forces
• 16:45 Sedentary lifestyle and other triggers
• 18:00 Movement, omega-3 fatty acids, herbal and prescriptive medications

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