Podcast Notes Playlist: Latest Episodes

Drive with Dr. Peter Attia

Podcast Notes Key Takeaways

• Check out The Drive Episode Page & Show Notes

Read the full notes @ podcastnotes.org

View the Show Notes Page for This Episode

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Celia Morgan is a Professor of Psychopharmacology at the University of Exeter who has authored numerous publications on the potential therapeutic uses of ketamine in mental healthcare. In this episode, Celia dives deep into the neurobiology of ketamine, how it affects users, and how it differs from other, more classical psychedelics (LSD, MDMA, PCP, and psilocybin). She explains the potential promise of ketamine as a treatment for recalcitrant depression and addiction, and she details the results from her clinical trials in these areas. She discusses the importance of using ketamine in combination with psychotherapy to maximize its benefits, the potential risks associated with ketamine use, and advice for those interested in the therapeutic use of ketamine.

We discuss:

• Celia’s training and interest in ketamine [2:15];
• The history of ketamine, medical uses, and use as a party drug [3:30];
• Neurobiology and pharmacology of ketamine [8:15];
• Ketamine regulation and abuse, and how it compares with psychedelics and other molecules [18:15];
• Ketamine as a therapeutic for depression [30:45];
• The brain under the influence of ketamine and theoretical mechanisms for its anti-depressive effects [48:00];
• Risks and concerns with overusing ketamine, and what an intermittent or maintenance dose might look for a patient [57:15];
• Treating addiction with ketamine: Celia’s studies of alcohol dependance [1:04:00];
• Advice for people considering the therapeutic use of ketamine [1:19:45];
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

Neuroscientist Erik Hoel talks about why he is not an "effective altruist" with EconTalk host, Russ Roberts. Hoel argues that the utilitarianism that underlies effective altruism--a movement co-founded by Will MacAskill and Peter Singer--is a poison that inevitably leads to repugnant conclusions and thereby weakens the case for the strongest claims made by effective altruists.

Modern Wisdom

Podcast Notes Key Takeaways

• Check out the Modern Wisdom Podcast Episode Page & Show Notes

Read the full notes @ podcastnotes.org

Catherine Salmon is an evolutionary psychology researcher, professor of Psychology at the University of Redlands and an author.

Women can be a mystery, sometimes even to themselves. Modern culture is making many proclamations about what women like and why they should like it, but are these new headlines accurate, or even desirable?

Expect to learn why women love erotic stories so much, whether evolutionary psychology is sexist, why Catherine did a study where people rated the attractiveness of faces which had jizz on them, why feminine men are being pushed in media but don't feature in dark romance novels, the role of commitment in female attraction and much more...

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Episode 369: Sam Parr (@TheSamParr) and Producer Ben (@BenWilsonTweets) take a turn with One Question Friday... instead of a question they discuss traits of conquerors from yesterday and today.

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Links:

* My First Million

* How To Take Over The World

* Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel.

* Want more insights like MFM? Check out Shaan's newsletter.

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Show Notes:

(02:25) - lessons from Hitler

(10:45) - lessons from Edison

(10:25) - addictive personalities

(18:10) - charismatic people

(26:25) - bias to action

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Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more.

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Additional episodes you might enjoy:

• #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits

• #209 Gary Vaynerchuk - Why NFTS Are the Future

• #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto

* #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett

• ​​​​#218 - Why You Should Take a Think Week Like Bill Gates

• Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More

• How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

My guest is Casey Halpern, M.D., Chief of Stereotactic and Functional Neurosurgery and Professor of Neurosurgery at the Perelman School of Medicine at the University of Pennsylvania. Dr. Halpern’s research and clinical practice focus on using deep brain stimulation to treat compulsive and movement disorders (e.g., binge eating disorders, bulimia, obsessive-compulsive disorder (OCD) and Parkinson’s disease essential tremor, dystonia). We discuss using deep brain stimulation to help patients who suffer from movement and compulsive disorders and applying this treatment to patients afflicted with binge eating. We also explore applications of this technology to other conditions such as OCD, anorexia and tremor, and the future therapeutic directions of the use of non-invasive brain stimulation approaches, including transcranial magnetic stimulation and ultrasound, for the treatment of other psychiatric illnesses and conditions. This episode will interest those curious about the biology of eating, anorexia, bulimia, compulsive thoughts and behaviors, and movement.

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For the full show notes, visit hubermanlab.com

Timestamps

(00:00:00) Dr. Casey Halpern & Disordered Eating & Brain Stimulation

(00:03:18) ROKA, Eight Sleep, InsideTracker

(00:07:19) Momentous Supplements

(00:08:28) Neurosurgeon’s View of the Brain, Neurosurgery Specialization

(00:13:05) Deep Brain Stimulation & Other Unexpected Positive Effects

(00:17:20) Obsessive Compulsive Disorder (OCD), Prescriptions & Cognitive Therapies

(00:25:40) Brain Areas in OCD, Risk, Rewards & Addiction

(00:31:11) AG1 (Athletic Greens)

(00:32:27) Facial and Vocal Ticks, Stimulants, Stress & Superstition

(00:39:28) Nucleus Accumbens, Reward Circuits, Eating Disorders & Obesity

(00:47:18) Stimulation of Nucleus Accumbens, Continuous vs. Episodic Stimulation

(00:49:49) Binge Eating Disorder & Loss of Control Eating

(00:53:02) Developing Binge Eating Disorder: Predisposition, Environment, Stress

(01:02:07) Electrodes in Nucleus Accumbens, Identifying “Craving Cells”

(01:11:41) Effects of Stimulation, Interrupting Craving, Intermediate Stimulation

(01:16:46) Anorexia, Obesity & Compulsions, Potential Treatments for Anorexia

(01:23:14) Non-Invasive Brain Stimulation, Transcranial Magnetic Stimulation

(01:32:27) MRI-Guided Focused Ultrasound: Tremor, Essential Tremor & Parkinson’s

(01:36:40) Future of Non-Invasive Brain Stimulation, Epilepsy & Depression

(01:41:51) Pre-Behavioral States in Compulsion & Awareness, Mood Provocation

(01:48:02) Machine Learning/Artificial Intelligence & Compulsion Predictions

(01:53:05) Neurosurgeon Hands, Resistance Training & Deadlifts

(01:59:00) “Neurosurgeon Calm,” Quality Time & Prioritization, Neurosurgeon Training

(02:09:53) Daily Habits: Sleep, Exercise, Mediation

(02:11:59) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn

 Title Card Photo Credit: Mike Blabac

Disclaimer

Knowledge Project

Podcast Notes Key Takeaways

• When scaling a company: “You have to be constantly evolving your learning pattern. What got you here, won’t get you there.”– Reid Hoffman
  • Examples: how you organize your management (work vs management duties in each role), go-to-market strategy (how to get new sales), adjusting the cadence of hiring (promoting from within vs outside org)
  • This applies to our lives too, not just business!
• Want to be a better leader?“Root for better angels on people”– Shane Parrish quoting Reid Hoffman
  • Make everyone the hero of their own story—people often don’t realize their own potential to make the world a better place
• It’s timely and costly not to have a process for making fast decisions, here’s how to improve (continue reading for more detailed instructions):
  • Be an explicit leaner
  • Learn your set of decision-guiding questions
  • Identify irreversible consequences
• You should never try to optimize opportunity cost to be 100% efficient
  • Some of your decisions will seem like an opportunity cost upfront but turn out to be one of your most valuable experiences
  • You must leave yourself some room for exploration and serendipity

Read the full notes @ podcastnotes.org

Few figures have shaped the way we think about business over the past 20 years more than Reid Hoffman. The co-founder of LinkedIn and former PayPal executive is also a wildly successful venture capitalist, author and podcaster, but he didn’t get to his place as a Silicon Valley giant without making plenty of crucial decisions. On this episode Hoffman discusses lessons learned from decades spent as a hands-on operator and investor, including what he knows about scaling that others miss, the three principles of decision making, how to constantly evolve your learning pattern, and why the best leaders adapt to the crisis at hand.

Hoffman is perhaps best known for co-founding the professional networking site LinkedIn, which he started in 2003 and later sold for a reported $26.2 billion to Microsoft in 2016. Prior to founding LinkedIn, Hoffman was one of the first employees at PayPal, where he served as an executive vice president. He is also a partner at the venture capital firm Greylock Partners, an investor in Airbnb, the author of a series of successful business books including Masters of Scale, and the host of the podcast of the same name.

Want to hear the entire episode with Reid Hoffman? Become a member today! Members get early access, hand-edited transcripts, member-only episodes, and so much more.

Learn more here: https://fs.blog/membership/

Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/

Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

The Rational Reminder Podcast

✓

Claim

Podcast Notes Takeaways

• Here is a summary breakdown of expected returns for alternative asset classes:

Read the full notes @ podcastnotes.org

The type of assets which usually come to mind when considering investments are stocks, bonds, or cash, but what are the alternatives? And what kind of returns do alternative asset classes offer? In today’s episode, we delve into the returns which can be expected from alternative asset classes such as private equity, venture capital, angel investing, private credit, hedge funds, direct real estate, and cryptocurrencies. Hear an in-depth analysis based on empirical studies and the expertise of your hosts, Ben and Cameron, to discover whether there is any merit to alternative asset classes as investments. We unpack the extra layer of complexity associated with predicting returns on alternative assets, how to approach calculating returns, and why the associated fees are an essential consideration. We also hear details about an interesting conference Cameron recently attended and briefly recap cryptocurrencies as an investment. You’ll also hear our conversation with our 22 in 22 reading challenge guest David Senra about his reading habits, the books that most inspire him, and his advice for people who want to read more.

 

Key Points From This Episode:

 

• Outline of today’s main topic: expected returns for alternative asset classes. (0:01:51)
• Why predicting returns of alternative asset classes has an extra layer of complexity. (0:03:18)
• How to approach estimating the returns of private equity, specifically buyouts. (0:05:04)
• We unpack historical data regarding the returns of private equity. (0:07:35)
• Calculating the returns on venture capital and reasons to be cautious about it as an asset class. (0:16:35)
• The distribution of returns from venture capital based on the market numbers. (0:20:09)
• Learn what angel investing is and its associated returns. (0:20:54)
• What returns on angel investing are most dependent on and why. (0:22:21)
• The different types and the associated returns. (0:25:23)
• Hear about the fees associated with private credit. (0:27:42)
• We unravel the concept of hedge funds, the associated fees, and expected returns. (0:29:29)
• A limiting factor on hedge funds: capacity constraints. (0:33:38)
• The takeaway regarding private real estate investments. (0:36:25)
• How private real estate is valued as an asset class. (0:37:48)
• Cryptocurrencies and the returns to be expected. (0:39:34)
• We discuss some of the key takeaways from today’s main topic. (0:43:30)
• We follow up on a previous topic we covered: financial literacy. (0:45:10)
• Find out about an interesting conference that Cameron recently attended. (0:48:46)
• Hear about the recent reviews we have received about the podcast. (0:57:58)
• We introduce our 22 and 22 reading challenge guest, David Senra. (01:00:15)
• Where David’s passion for reading about founders originates from. (01:02:25)
• David shares details about his reading habits. (01:05:57)
• His approach to finding founders that he wants to read about. (01:08:49)
• David’s approach to note taking while reading a book. (01:11:07)
• We learn about the stories that have impacted David the most. (01:13:53)
• He explains the benefits of reading a book for a second time. (01:17:11)
• Books about founders that he thinks everyone should read. (01:19:20)
• David’s observation of the role of luck in a founder’s success story. (01:23:19)
• Advice he has for people who want to read more. (01:29:33)

 

Links From Today’s Episode:

 

AQR Capital Management — https://www.aqr.com/

BlackRock Asset Management — https://www.blackrock.com

Bank of America — https://www.bankofamerica.com/

‘The risk and return of venture capital’ — https://www.sciencedirect.com/science/article/pii/S0304405X04001564

‘Performance of Private Credit Funds: A First Look' — https://jai.pm-research.com/content/21/2/31.short

‘Do Hedge Funds Hedge?’ — https://jpm.pm-research.com/content/28/1/6.short

‘The Performance of Hedge Fund Performance Fees’ — https://www.nber.org/papers/w27454

‘Higher risk, lower returns: What hedge fund investors really earn’ — https://www.sciencedirect.com/science/article/abs/pii/S0304405X1100016X

‘Another Look at Private Real Estate Returns by Strategy’ — https://jpm.pm-research.com/content/45/7/95/tab-pdf-trialist

'The Characteristics and Portfolio Behavior of Bitcoin Investors: Evidence from Indirect Cryptocurrency Investments' — https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3501549

‘Beliefs and the Disposition Effect’ — https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3516567

‘Once Bitten, Twice Shy: The Power of Personal Experiences in Risk Taking’ — https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2506627

S&P Global FinLit Survey — https://gflec.org/initiatives/sp-global-finlit-survey/

Future Proof Conference — https://futureproof.advisorcircle.com/

Invest Like the Best Podcast — https://investlikethebest.libsyn.com/

David Senra on LinkedIn — https://www.linkedin.com/in/david-senra-278843236/

David Senra on Twitter — https://twitter.com/FoundersPodcast?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor

David Senra on Facebook — https://www.facebook.com/david.senra.1

The Founders Podcast — https://founders.simplecast.com/

A Triumph of Genius — https://www.amazon.com/Triumph-Genius-Edwin-Polaroid-Patent/dp/1627227695

Cable Cowboy — https://www.amazon.com/Cable-Cowboy-Malone-Modern-Business/

Titan — https://www.amazon.com/Rare-Chernow-Titan-Life-Rockefeller/

A Man for All Markets — https://www.amazon.com/Man-All-Markets-Street-Dealer/

Against the Odds — https://www.amazon.com/Against-Odds/

Estee: A Success Story — https://www.amazon.com/Estee-Success-Story-Lauder/

Rational Reminder on iTunes — https://itunes.apple.com/ca/podcast/the-rational-reminder-podcast/id1426530582.
Rational Reminder Website — https://rationalreminder.ca/

Rational Reminder on Instagram — https://www.instagram.com/rationalreminder/?hl=en

Rational Reminder on YouTube — https://www.youtube.com/channel/
Ben Felix — https://www.pwlcapital.com/author/benjamin-felix/

Ben on Twitter — https://twitter.com/benjaminwfelix

Ben on LinkedIn — https://www.linkedin.com/in/benjaminwfelix/

Cameron Passmore — https://www.pwlcapital.com/profile/cameron-passmore/

Cameron on Twitter — https://twitter.com/CameronPassmore

Cameron on LinkedIn — https://www.linkedin.com/in/cameronpassmore/

 

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine’s ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body.

Thank you to our sponsors

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Supplements from Momentous

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For the full show notes, visit hubermanlab.com

Timestamps

(00:00:00) Nicotine

(00:02:47) Momentous Supplements

(00:03:41) Tool: Brief Daily Meditation & Focus

(00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements

(00:10:43) Thesis, InsideTracker, ROKA

(00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine

(00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors

(00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA

(00:30:58) AG1 (Athletic Greens)

(00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting”

(00:37:29) Nicotine, Norepinephrine & Alertness/Energy

(00:41:10) Nicotine & Effects on Appetite & Metabolism

(00:46:47) Nicotine & Effects on Body: Sympathetic Tone

(00:51:29) Nicotine & Cognitive Work vs. Physical Performance

(00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency

(00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells

(01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health

(01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal

(01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression

(01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri

(01:30:16) Bupropion (Wellbutrin) & Quitting Smoking

(01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum

(01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy

(01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook

Title Card Photo Credit: Mike Blabac

Disclaimer

Modern Wisdom

Podcast Notes Key Takeaways

• Check out the Modern Wisdom Episode Page & Show Notes

Read the full notes @ podcastnotes.org

Gurwinder Bhogal is a programmer and a writer.

Gurwinder is one of my favourite Twitter follows. He’s written yet another megathread exploring human nature, cognitive biases, mental models, status games, crowd behaviour and social media. It's one of the best things I've read this year, so I just had to bring him on.

Expect to learn how bad things can sometimes feel better than good things, why people die on the hill of opinions they've only just begun believing, why intelligence plus ideology is a nightmare, how comedy can be a troll's last line of defence, the biggest lesson I learned from Joe Rogan, why regret minimisation should be a priority, why authoritarians lose sight of rationality and much more...

Sponsors:

Get over 37% discount on all products site-wide from MyProtein at https://bit.ly/proteinwisdom (use code: MODERNWISDOM)

Get 20% discount & free shipping on your Lawnmower 4.0 at https://www.manscaped.com/ (use code MODERNWISDOM)

Get the Whoop 4.0 for free and get your first month for free at http://join.whoop.com/modernwisdom (discount automatically applied)

Extra Stuff:

Check out Gurwinder's Substack - https://gurwinder.substack.com/

Follow Gurwinder on Twitter - https://twitter.com/G_S_Bhogal

Gurwinder's new MegaThread - https://twitter.com/G_S_Bhogal/status/1545510413982474253 

Adam Mastroianni's post - https://experimentalhistory.substack.com/p/underrated-ideas-in-psychology 

Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/

To support me on Patreon (thank you): https://www.patreon.com/modernwisdom

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Get in touch.

Instagram: https://www.instagram.com/chriswillx

Twitter: https://www.twitter.com/chriswillx

YouTube: https://www.youtube.com/modernwisdompodcast

Email: https://chriswillx.com/contact/ 

Ray Kurzweil is an author, inventor, and futurist. Please support this podcast by checking out our sponsors: – Shopify: https://shopify.com/lex to get 14-day free trial – NetSuite: http://netsuite.com/lex to get free product tour – Linode: https://linode.com/lex to get $100 free credit – MasterClass: https://masterclass.com/lex to get 15% off – Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Ray’s Website: https://kurzweilai.net Ray’s Books: The Singularity Is Nearer (pre-order): https://amzn.to/3BNXmGR How To Create A Mind: https://amzn.to/3qqlkBw The Singularity Is Near: https://amzn.to/3DfXP5z The Age of Spiritual Machines: https://amzn.to/3RSjtAX Danielle: https://amzn.to/3Bww2N7 Transcend: https://amzn.to/3RAEYGV PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: