Podcast Notes Playlist: Latest Episodes

(for EPISODES 39 - 41, visit the IMA YouTube channel)

Author of Fossil Future, Alex Epstein, shares his expertise and philosophical perspective on climate, energy and fossil fuels. Watch as Entrepreneur Peter Thiel and Epstein dive deep into the truths and arguments behind what most people may think is insane. Learn from these experts what is in the future for technology, inflation, climate and why it is okay to be optimistic even in these trying times.

Join Marty as he sits down with Lord Miles to discuss traversing Afghanistan during a time of war. They also discuss the aftermath of visiting countries under sanctions, the global spring upon us and just how fake news coverage by the mainstream is perpetrated.  

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• Ways to safely add friction to your life & raise stress threshold to enhance your ability to stay calm under pressure: cold shower, ice bath, cyclic hyperventilation – stress grows you
• Grief is a motivated state of being highly alert but very sad, where we try to bridge the space and time of a loved one but it’s impossible since that person is gone – the brain has to confront the reality that someone is gone
• The ability to feel the feelings helps you move through a breakup: women reportedly experience higher levels of emotional pain during a breakup but recover more fully over time; men rarely fully recover
• If we expose regularly expose ourselves to things that trigger high levels of dopamine release, we will actually lower our baseline levels of dopamine over time
• To maintain high levels of motivation, try intermittent rewards: celebrate successes every other time, every tenth time, etc. to blunt dopamine response, prevent crashes, and keep you on the path to bigger goals
• Lessons from Lex Fridman: There are a lot of energy pits but success is really about not allowing energy to dissipate into negative trails (e.g., fighting people online, cynics, etc.)
• Evolutionarily, mating is a test as to whether two people can coordinate autonomic nervous systems
• Actual + perceived = reality: any event causes a real physiological response, but that response is entangled with our expectation of what the response should be
• Tap into whatever eating system works for you – but one thing is true, consistency helps anchor your sleep schedule
• Light, exercise, and temperature (hot and cold) are potent stimuli for creating hormonal and neuromodulator effects – it works the first time and every time

Dr Andrew Huberman is a neuroscientist, Associate Professor at the Stanford University School of Medicine and a podcaster.

The mind and the body are intimately linked. Trying to improve your mental outcomes without thinking of your physical inputs is a losing battle, but the question of which inputs to use, and when is a huge challenge. Thankfully, Dr Huberman is one of the best communicators of high performance advice on the planet and has a lot of answers.

Expect to learn the neuroscience of getting over your ex, how David Goggins trained himself to lean into fear, whether dopamine detoxing really works, the most important things to avoid doing during your morning routine, just how worried we should be about men's testosterone levels dropping, what everyone can learn about endurance from Lex Fridman, why Andrew doesn't show his tattoos and much more...

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• CRISPR is a subset of editing; editing is a subset of genome engineering; genome engineering is gene therapy
• “Shrinking our agricultural use, possibly by 10 or 100 fold is feasible to do with synthetic biology and other new tools.” – Dr. George Church
• Advances in reading and writing DNA double at least once per year; most of the exponential increase has occurred in the last 10-20 years
• Cons of synthetic biology: lack of equity in access to technology and treatments; head in the sand approach to new technologies – FDA does not review; ethical considerations
• Preventive medicine in genetics: genetic counseling preconception would be helpful to understand the future of offspring (as opposed to spending millions over a lifetime in gene therapy if disease is present)
• Aging studies in dogs (as opposed to rodents) are good parallel to outcomes in humans because they’re large, live in human environments, have similar emotions, and bonding
• “What’s natural is a moving target – a lot of things that were demonized or villainized in the past are now taken for granted, for example, some of us might remember how cell phones with were demonized as melting your brain or getting radiation to your brain.” – Dr. George Church
• Gene editing therapy has the potential to reduce medical load, improve agriculture, alleviate some poverty burden (if there’s less disease), eliminate disease animal-human transmission, eliminate or reduce germline disease
• There is no way to have zero risk – status quo is risky, but we should start small in animal studies and then progress to human studies

George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology. 

In this episode, we discuss:

• 07:13 - History of the Human Genome Project
• 15:20 - Manufacturing cell phones (with biology)
• 17:34 - Genome Project-Write
• 20:03 - Writing a human Y chromosome (from scratch)
• 20:48 - What if you could eliminate viral disease?
• 22:51 - De-extinction and reinstating lost traits and genes
• 27:06 - The Vertebrate Genomes Project
• 29:47 - AlphaFold and other AI tools
• 41:27 - CRISPR vs. Base Editing (emerging tools of genetic engineering)
• 49:40 - Why multiplex editing will change the world
• 52:18 - Molecular flight recorder
• 53:31 - Preventing viral spillover and enhancing livestock
• 57:40 - PCSK9 gene therapy for cholesterol
• 01:00:30 - Is aging an evolved program?
• 01:05:21 - Treating aging with a combination gene treatment
• 01:09:04 - Does animal research help us understand human aging?
• 01:11:40 - Human organoids as a model and therapeutic
• 01:13:34 - Could engineered transplant organs become better than the originals?
• 01:16:17 - Embryo editing controversy
• 01:28:41 - Gene editing for space travel
• 01:30:40 - Can synthetic biology alleviate poverty?
• 01:34:07 - Is in vitro fertilization and embryo selection practically similar to editing?
• 01:39:12 - The occasional cost of brilliance
• 01:45:45 - Eradicating disease with Gene Drive
• 01:48:55 - Technologies to solve Lyme disease
• 01:51:57 - Dr. Church's experience with narcolepsy as a bridge to creative insights
• 02:00:42 - Why George encoded his book in DNA

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