Podcast Notes Playlist: Latest Episodes

Podcast Notes Playlist: Latest Episodes

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Podcast Notes Playlist: Latest Episodes episodes

  • What Alcohol Does to Your Body, Brain & Health | Episode 86
    In this episode, I discuss the physiological effects that drinking alcohol has on the brain and body at different levels of consumption and over time. I also describe genetic differences that predispose certain individuals to alcoholism, binge and habit-drinking. I explain alcohol metabolism in simple terms and how it effectively acts as a poison, leading to cellular stress and damage. I then explain that it impacts neuronal function and changes our thinking and behavior – hallmarks of inebriation. I also discuss how alcohol consumption of different amounts impacts inflammation, stress, neurodegeneration, and cancer risk and negatively impacts the gut microbiome, brain thickness, hormone balance, mood and feelings of motivation. Additionally, I discuss the biology of hangovers and describe science-based strategies to mitigate the severity of a hangover. Since alcohol is one of the most widely consumed recreational substances, this episode ought to be of relevance to everyone.  Indeed, even low-to-moderate alcohol consumption negatively impacts the brain and body in direct ways. The goal of this episode is to help people make informed decisions about their alcohol consumption that are in keeping with their mental and physical health goals. 
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    Levels: https://levels.link/huberman
    Eight Sleep: https://www.eightsleep.com/huberman
    ROKA: https://www.roka.com/huberman
    Supplements from Momentous
    https://www.livemomentous.com/huberman
    For the full show notes, visit hubermanlab.com
    Timestamps
    (00:00:00) Effects of Alcohol Consumption
    (00:02:25) Momentous Supplements 
    (00:03:19) Low to Moderate Alcohol Consumption & Neurodegeneration 
    (00:06:52) Levels, Eight Sleep, ROKA 
    (00:10:46) Historical Context & Uses of Alcohol 
    (00:13:28) Alcohol Metabolism, “Empty Calories” 
    (00:18:23) Inebriation: Top-Down Inhibition, Impulsivity & Memory Formation
    (00:24:23) Long-Lasting Effects & Impulsivity, Neuroplasticity & Reversibility 
    (00:27:55) Food & Alcohol Absorption
    (00:30:07) Alcohol & Serotonin, SSRIs & Depression, Risk for Alcoholism, Blackouts
    (00:37:39) Predisposition for Alcoholism; Chronic Consumption, Cortisol & Stress
    (00:44:53) AG1 (Athletic Greens)
    (00:46:07) Genetic Predisposition for Alcoholism, Consuming Alcohol Too Young
    (00:52:27) Gut-Liver-Brain Axis: Alcohol, Gut Microbiome, Inflammation & Leaky Gut 
    (00:59:46) Tool: Improving/Replenishing Gut Microbiome 
    (01:02:44) Reducing Alcohol Consumption & Stress 
    (01:04:25) Hangover: Alcohol & Sleep, Anxiety, Headache
    (01:12:11) Hangover Recovery, Adrenaline & Deliberate Cold Exposure 
    (01:17:16) Hangover Recovery, Dehydration & Electrolytes
    (01:20:45) Types of Alcohol & Hangover Severity, Congeners  
    (01:25:25) Alcohol Tolerance, Dopamine & Serotonin, Pleasure-Pain Balance   
    (01:33:36) Are There Any Positive Effects of Alcohol?, Resveratrol 
    (01:35:42) Alcohol & Brain Thickness 
    (01:37:11) Alcohol & Cancer Risk: DNA Methylation, Breast Cancer Risk 
    (01:44:31) Mitigating Cancer Risk, Folate, B Vitamins 
    (01:46:54) Alcohol & Pregnancy, Fetal Alcohol Syndrome 
    (01:50:58) Hormones: Testosterone & Estrogen Balance
    (01:55:09) Negative Effects of Alcohol Consumption 
    (01:58:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips
    Title Card Photo Credit: Mike Blabac
    Disclaimer
    2 hr 2 min
  • #514 - Peter Zeihan - The Old World Order Is About To Collapse
    Modern Wisdom


    Podcast Notes Takeaways
    • Globalization is ending; the year 2019 is as good as it is ever going to be
    • After 70 years of people having fewer kids as a result of moving off the farm and into the city, the world is running out of mature adults, who are necessary for the consumption-based economic system to function 
    • From an economic perspective, the U.S. is better positioned than most nations because its post-war generation actually continued to have kids at the onset of globalization + America has a much higher mortality rate once people age past 55
      • American wealth gets cycled back to the younger generation much faster than in nations where people live to be much older


    Read the full notes @ podcastnotes.org



    Peter Zeihan is a geopolitical analyst, author and a speaker.

    The world is changing faster than ever, and a lot of the countries, dynamics, peace treaties and structures we're familiar with may be about to come to an end. Peter's job consists of him analysing data from geography, demographics, and global politics to understand economic trends and make predictions. And if his predictions are correct, the next 50 years are going to look incredibly different.

    Expect to learn why China will lose half of it's population by 2050, why globalisation is coming to an end even though we're more connected than ever, why population demographics are one of the most important factors in determining the future, whether automation will help or hinder us, whether food shortages are actually something to panic about and much more...

    Sponsors:

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    Get 15% discount on Craftd London’s jewellery at https://bit.ly/cdwisdom (use code MW15)

    Extra Stuff:

    Buy The End Of The World Is Just The Beginning - https://amzn.to/3AekTQz 

    Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/

    To support me on Patreon (thank you): https://www.patreon.com/modernwisdom

    -

    Get in touch.

    Instagram: https://www.instagram.com/chriswillx

    Twitter: https://www.twitter.com/chriswillx

    YouTube: https://www.youtube.com/modernwisdompodcast

    Email: https://chriswillx.com/contact/ 

    1 hr 9 min
  • LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Seattle, WA
    Recently I had the pleasure of hosting two live events, one in Seattle, WA and one in Portland, OR. These events were part of a lecture series called The Brain Body Contract. My favorite part of each evening was the question & answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event in Seattle, WA.
    Attend The Brain Body Contract Live Events
    Los Angeles, CA: October 16, 2022
    New York, NY: November 9, 2022
    https://hubermanlab.com/tour
    Presale password: huberman
    Thank you to our sponsors
    Momentous: https://www.livemomentous.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Timestamps
    (00:00:00) The Brain Body Contract Q&A
    (00:01:07) Momentous Supplements, InsideTracker
    (00:01:35) Upcoming Live Events: Los Angeles & New York
    (00:02:16) What Is Your Most-Used Protocol?
    (00:04:12) Should You Vary Wake-Up Time Seasonally?
    (00:06:05) Why Is My Drive Depleted Upon Waking-Up?
    (00:08:42) What Are Your Favorite/Most Impactful Books?
    (00:12:08) What Excites You About the Future of Mental Health Treatment?
    (00:17:25) What Is the Biggest Area Tor Performance Enhancement?
    (00:21:44) Can You Still Do a Kickflip?
    (00:22:32) Tips on How to Improve Memory
    (00:24:54) How Do You Manage Social Media Addiction?
    (00:27:43) Were You Nervous Tonight/ How Did You Prepare?
    (00:29:10) Is Learning from Failure Equal to Learning from Success?
    (00:32:23) When Are You Going to Start Training Jiu-Jitsu?
    (00:33:28) Discuss the Supplements You Take
    (00:36:29) Advice or Protocols to Improve Learning & Retention
    (00:38:42) What Exciting Research/Work are You Doing?
    (00:40:22) How Does Dopamine Factor into Neuroplasticity?
    (00:43:12) What Advice Do You Have for Future Scientists?
    (00:46:47) Is Age 66 Too Old for Neuroplasticity & Learning?
    (00:48:00) How Do You Read Research Papers?
    (00:49:40) What is Your Favorite Condiment?
    (00:50:10) Most Important Takeaway from Your ADHD Research?
    (00:52:58) What Future Episodes Are in the Pipeline?
    Title Card Photo Credit: Mike Blabac
    Disclaimer
    57 min
  • Katherine Boyle - Investing for America - [Invest Like the Best, EP.290]
    Invest Like the Best


    Podcast Notes Key Takeaways
    • Improvements in the highly regulated American Dynamism sectors like defense, housing, education, and healthcare will come from technological improvements, not policy improvements
      • These are the most regulated, most subsidized, and lowest-competition sectors
    • American Dynamism is an initiative to repair and strengthen the relationship between Silicon Valley and Washington to solve issues facing all Americans 
    • Washington has a zero-sum culture that operates on short time horizons, while Silicon Valley has a positive-sum culture that operates on long time horizons
    • Authoritarianism gives Russia and China certain advantages over the U.S. because they can order their best technologists to build what the country needs, whereas the best technologists in the U.S. are left free to create better ad-optimizing tech for Snapchat 
    • American Dynamism founders must be great storytellers;the technology is important, but the founder must be able to convince investors, customers, employees, and potential future employees that they are a paradigm-shifting company 
    • The government must turn to other sources than its defense-industrial base to solve its shortcomings in software, the Department of Defense’s realization of this has marked a paradigm shift in Washington 
    • The playbook for defense tech startups: Start competing for the smaller pockets of money that don’t touch the five defense primes (that receive 40% of the defense budget), and then move up the categories of spend and compete for contracts in areas that have been around for awhile 
    • People opting out of a system oftentimes improves the underlying system
    • COVID forced parents to adopt a new model of educating their children, and like remote work, many parents were pleasantly surprised by the efficacy of the home-schooling and micro-schooling method 
    • If all you need for work is an internet connection, people will move to states that are more aligned with their values and preferred policies, thus placing positive pressure on states to improve 
    • Prices in regulated, subsidized, low-competition industries like defense, healthcare, and education don’t come down because they don’t need to come down
    • Investors must be mission-aligned with the company or they shouldn’t be working with them  


    Read the full notes @ podcastnotes.org



    My guest today is Katherine Boyle, a general partner at Andreessen Horowitz. Katherine started her career as a reporter for The Washington Post before moving into VC at General Catalyst. She now leads a practice at a16z called American Dynamism, investing in companies that are solving critical issues in areas like defense, housing, and education. In the past year, I've spoken to Marc Andreessen, Josh Wolfe, and a number of founders about this need to build societally important businesses so I was excited to explore the topic in even more detail today. Please enjoy my conversation with Katherine Boyle.

     

    For the full show notes, transcript, and links to mentioned content, check out the episode page here.

     

    The content here is for informational purposes only and should not be taken as legal, business, tax or investment advice, or be used to evaluate any investment or security and is not directed at any investors or potential investors in any a16z fund. For more details, please see a16z.com/disclosures.

     

    -----

     

    This episode is brought to you by Tegus. Tegus streamlines the investment research process so you can get up to speed and find answers to critical questions on companies faster and more efficiently. The Tegus platform surfaces the hard-to-get qualitative insights, gives instant access to critical public financial data through BamSEC, and helps you set up customized expert calls. It’s all done on a single, modern SaaS platform that offers 360-degree insight into any public or private company. As a listener, you can take Tegus for a free test drive by visiting tegus.co/patrick. And until 2023 every Tegus license comes with complimentary access to BamSec by Tegus.

     

    -----

     

    Today's episode is brought to you by Brex. Brex is the integrated financial platform trusted by the world's most innovative entrepreneurs and fastest-growing companies. With Brex, you can move money fast for instant impact with high-limit corporate cards, payments, venture debt, and spend management software all in one place. Ready to accelerate your business? Learn more at brex.com/best.

     

    -----

     

    Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit joincolossus.com/episodes. 

     

    Past guests include Tobi Lutke, Kevin Systrom, Mike Krieger, John Collison, Kat Cole, Marc Andreessen, Matthew Ball, Bill Gurley, Anu Hariharan, Ben Thompson, and many more.

     

    Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here.

     

    Follow us on Twitter: @patrick_oshag | @JoinColossus

     

    Show Notes

    [00:02:42] - [First question] - The origin and overview of the term American Dynamism 

    [00:05:01] - Why the shift to a move slow and make sure nothing breaks mentality

    [00:07:31] - What about the American system today feels broken and stale 

    [00:09:48] - Becoming a journalist at The Washington Post 

    [00:11:35] - Describing the power landscape of media as it exists today  

    [00:12:28] - Major categories of American Dynamism that matter most  

    [00:14:29] - What matters more or less to her as an investor in  these categories 

    [00:17:31] - Whether or not there’s anything fundamentally broken about our government

    [00:19:36] - The Systems Bible; What excites her about aerospace and defense and what creates opportunity and demand in these sectors

    [00:22:44] - Explanation of what it means when the factory is the product 

    [00:23:47] - How much is flowing into aerospace and defense currently 

    [00:26:01] - An overview of how lobbying works and who does it and why

    [00:29:07] - Whether or not she considers these sectors from a bottom up perspective as in investor   

    [00:30:32] - What other categories she feels pulled towards 

    [00:33:09] - The biggest problems that currently exist in the K-12 school system 

    [00:35:34] - Thoughts on how states are competing citizens and how it plays into American Dynamism

    [00:37:34] - The role immigration will play in range of outcomes in these main categories 

    [00:39:32] - Key takeaways about housing in light of American Dynamism  

    [00:42:09] - Her interpretation of the chart that shows inflation in categories over time

    [00:44:40] - How different the investing dynamics are in all of these categories and thoughts on valuation in this world 

    [00:47:56] - Whether or not expected returns and risk profiles are different in this area 

    [00:48:36] - The importance of effective a founder’s storytelling, knowledge and customer empathy

    [00:49:55] - Overview of the anatomy of a great story  

    [00:51:30] - The story she tells founders at this stage so establish a partnership 

    [00:52:46] - The kindest thing that anyone has ever done for her

    55 min
  • Balaji Srinivasan - Exploring the Decentralized Science Reformation

    Welcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show!    

    Topics of this episode:  

    → Key factors holding back scientific progress and how to change it (also via DeSci). 🧪
    → What role does AI play here?
    → The future of human optimalism.
    → How to make predictions in technology?
    (+ many more & some great advice for DeSci builders at the end from Balaji)  

    Due to his nature, we're slipping in many other interesting topics while tackling those above! 💙  

    A huge thanks again to Balaji for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  

    Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps and the show-notes below.   

    If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

    You'll also find all links to Spotify, Discord, Twitter and our website via the link below - https://linktr.ee/thedescipodcast

    _____  

    Special thanks to:   

    Alex LaBossiere (Host): https://twitter.com/adlabossiere
    Vincent Weisser (Chief Ecosystem Development Officer of Molecule): https://twitter.com/vincentweisser
    Balaji Srinivasan: https://twitter.com/balajis
    https://balajis.com/
    https://balajis.com/the-purpose-of-technology/
    https://thenetworkstate.com/

    ______ 

    Timestamps:  

    00:00 - Intro  
    01:30 - Introduction of Balaji & The Network State
    06:45 - Key factors holding back scientific progress
    14:17 - How to change the research & funding structure
    21:00 - Commonalities between New York Times and the nature of the Scientific Journals
    38:00 - How does scientific progress unfold?
    44:50 - Can AI be a dominant driver here?
    49:10 - How to make predictions in technology
    54:40 - The cyclical approach of history  
    01:02:48 - Advice for builders in the DeSci space
    01:04:29 - Last words, book advice & outro  

    ______

    Show-notes of the episode:   

    https://twitter.com/balajis https://balajis.com/
    https://balajis.com/the-purpose-of-technology/ https://thenetworkstate.com/
    https://nexus.od.nih.gov/all/2021/11/18/long-term-trends-in-the-age-of-principal-investigators-supported-for-the-first-time-on-nih-r01-awards/ https://newscience.org/nih/
    https://twitter.com/patrickc/status/1544067890403389441
    https://project-evidence.github.io/ https://www.quantamagazine.org/in-new-math-proofs-artificial-intelligence-plays-to-win-20220307/ https://github.com/camoverride/lit/blob/master/The-Princeton-Companion-to-Mathematics.pdf

    ______  

    Let's connect:  

    Website: https://bit.ly/3BXtFUn
    Twitter: https://twitter.com/Molecule_dao
    Discord: https://discord.com/invite/moleculedao

    Molecule - The future of medicine belongs to everyone


    1 hr 7 min
  • Sleep Toolkit: Tools for Optimizing Sleep & Sleep-Wake Timing | Episode 84
    In this episode, I describe a comprehensive toolkit consisting of behavioral and supplement-based tools that you can customize to enhance the quality, duration and impact of your sleep. This has an enormous positive impact on your overall health and daytime functioning, brain, hormones and immune system. I teach you how to effectively harness light (and darkness), temperature, food, exercise, caffeine, supplements, and digital devices in order to fall asleep faster, stay deeply asleep longer and overall, and achieve better quality sleep. I also describe how these tools can be modified to recover quickly from a poor night’s sleep, jet lag or bouts of shift work. Given that sleep is the foundation of all mental health, physical health and performance, this episode should benefit everyone as it provides an essential toolkit of science-supported, low- to zero-cost strategies that can be tailored to optimize your sleep routine.
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Eight Sleep: https://www.eightsleep.com/huberman
    LMNT: https://drinklmnt.com/huberman
    Supplements from Momentous
    https://www.livemomentous.com/huberman
    For the full show notes, visit hubermanlab.com
    Timestamps
    (00:00:00) Tools to Optimize Sleep
    (00:03:02) Momentous Supplements
    (00:04:16) InsideTracker, Eight Sleep, LMNT
    (00:08:24) Factors to Control Circadian Rhythm & Sleep
    (00:15:10) Morning Tool: Morning Sunlight Viewing, Cortisol
    (00:20:44) Morning Sunlight: Circadian Rhythm, Artificial Lights, Cloudy Days
    (00:26:18) Evaluating Light in Environment, Compensating for Missed Morning Light
    (00:29:26) AG1 (Athletic Greens)
    (00:30:46) Morning Tools: Temperature & Deliberate Cold Exposure, Exercise
    (00:34:58) Timing Caffeine, “Afternoon Crash,” Exercise
    (00:40:08) Timing Eating, Alertness & Circadian Rhythm
    (00:45:20) 3 Daily Critical Periods
    (00:46:49) Afternoons: Naps, Deep Relaxation (NSDR, Self-Hypnosis), Exercise & Body Temperature, Caffeine
    (00:51:59) Afternoon Tools: Viewing Sunlight in Late Afternoon, Evening Light
    (00:56:45) Evening/Night Tools: Overhead Artificial Lights, Light Sensitivity
    (01:04:40) Evening Tools: Hot Bath/Sauna, Temperature & Sleeping Environment
    (01:09:40) Alcohol, THC & Reduced Sleep Quality; CBD, Anxiety & Falling Asleep
    (01:11:45) Sleep Supplements: Magnesium Threonate, Apigenin & Theanine
    (01:16:34) Melatonin Supplementation (Caution)
    (01:17:44) Additional Sleep Supplements: GABA, Glycine, Myo-Inositol & Anxiety
    (01:20:08) Falling Back Asleep: Reveri App, NSDR, Yoga Nidra
    (01:22:55) Staying Asleep: Eye Masks, Ear Plugs, Elevating Feet
    (01:24:58) Tool: Sleep Apnea & Nasal Breathing
    (01:28:20) Sleep Schedule Consistency, Weekends, Compensatory Sleep & Caffeine
    (01:31:14) Tools: Temperature Minimum & Jet Lag, Shift Work & Red Lights
    (01:37:38) Behavioral Tools for 3 Daily Critical Periods
    (01:39:26) Zero-Cost Support, YouTube Feedback, Huberman Lab Clips, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
    Title Card Photo Credit: Mike Blabac
    Disclaimer
    1 hr 42 min
  • Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity | Episode 85
    My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health. 
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    Thesis: https://takethesis.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Helix Sleep: https://helixsleep.com/huberman
    Supplements from Momentous
    https://www.livemomentous.com/huberman
    For the full show notes, visit hubermanlab.com
    Timestamps
    (00:00:00) Assessing Health Status & Improving Vitality 
    (00:02:51) Momentous Supplements 
    (00:03:46) Thesis, InsideTracker, Helix Sleep 
    (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease” 
    (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States 
    (00:13:59) Blood Testing: Best Frequency 
    (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis 
    (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids 
    (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training
    (00:31:03) AG1 (Athletic Greens)
    (00:32:16) Back-casting: Defining Your “Marginal Decade” 
    (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max 
    (00:44:43) Attia’s Rule of Supplementation, “Centenarian Decathlete” Physical Goals
    (00:49:24) Importance of Exercise, Brain Health, MET hours 
    (00:55:23) Nicotine & Cognitive Focus
    (01:03:12) Menstruation, PMS & Menopause 
    (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk
    (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women
    (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin
    (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG
    (01:47:46) Fadogia Agrestis, Supplements, Rapamycin 
    (01:52:06) Testosterone Replacement Therapy & Fertility 
    (01:59:26) Total Testosterone vs. Free Testosterone
    (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B
    (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions 
    (02:25:15) Cardiovascular Disease, Age & Disease Risk 
    (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation 
    (02:37:40) Metabolomics & Exercise 
    (02:40:44) GLP-1 & Weight Loss 
    (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips
    Title Card Photo Credit: Mike Blabac
    Disclaimer
    2 hr 51 min
  • How Building in Space Will Improve Life on Earth with Delian Asparouhov
    Are you stuck creating on the couch? In today's episode, we explain how one small group can change the world, debate whether these people need to meet in real life, and Delian shares why he feels start-ups must hire based on merit. Hosts Sahil Bloom and Greg Isenberg are joined by guest Delian Asparouhov, principal at the Founders Fund and co-founder of Varda. Delian explains the secret to running a billion-dollar fund while simultaneously launching his first company, shares his take on where the venture world is headed and explains how China is taking control with TikTok.
    ►► Want more community? Learn more here: http://trwih.com
    SPECIAL THANKS TO OUR SPONSOR
    ►► This episode is brought to you by Wealthfront, a saving and investing app that can help you earn more on your money and build wealth for your future. The Wealthfront Cash Account grows your savings at 1.40% APY, and offers unlimited, fee-free transfers to your external accounts — plus, a ton of other features that help you optimize your cash. So, if your money is earning less anywhere else, now might be a good time to make a move.
    Wealthfront is offering Where it Happens listeners a free $50 bonus with a $500 initial deposit to a new Cash Account. Go to wealthfront.com/Happens to claim your $50 and start growing your savings.
    Cash account is offered by Wealthfront Brokerage LLC, Member of FINRA/SIPC. Wealthfront Brokerage is not a bank. We convey funds to partner banks who accept and maintain deposits, provide the interest rate, and provide FDIC insurance. Rate is subject to change. Investment management and advisory services--which are not FDIC insured--are provided by Wealthfront Advisers LLC (“Wealthfront Advisers”), an SEC-registered investment adviser.
    THIS EPISODE
    Delian Asparouhov: https://twitter.com/zebulgar
    Sahil Bloom: https://twitter.com/SahilBloom
    Greg Isenberg: https://twitter.com/gregisenberg
    Production & Marketing Team: https://penname.co/
    FIND US ON SOCIAL
    Twitter: https://twitter.com/_trwih
    Instagram: https://www.instagram.com/_trwih
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    Spotify: https://open.spotify.com/show/6aB0v6amo3a8hgTCjlTlvh
    Apple: https://podcasts.apple.com/us/podcast/where-it-happens/id1593424985
    SHOW NOTES
    00:00 Sneak Peek
    01:11 Welcoming Delian
    02:23 How a Small Group Can Change the World
    07:54 Hiring Based on Merit
    10:14 Did ESG Create Change?
    13:40 TikTok Data Rights
    17:36 You Can’t Change the World from Your Couch
    21:55 Greg's Unique Perspective On Working Hard and a 10-Year Bet
    28:33 What is Varda and its Origin Story?
    37:31 Separating Design (+) Manufacturing = Innovation
    42:51 How to Become a Leader and Expert in Space
    45:34 The Secret to Founding a Start-Up and Running a Fund
    50:48 Delian’s Origin Story and His Prediction for the Future
    56:04 Thanks for Listening
    1 hr
  • 20VC: Fintech OG Sheel Mohnot on Lessons from Investing in Flexport and ChipperCash and Missing Robinhood and Chime, Why Overly Large GP Commits are Dangerous, Biggest Mistakes Managers Make with Fund I and Emerging Markets; Which Survive?
    Twenty Minute VC


    Podcast Notes Intro
    • Sheel Mohnot (@pitdesi) is a Co-Founder and General Partner at Better Tomorrow Ventures, a $225M venture fund for pre-seed and seed-stage fintech companies around the globe
    • Even if you’re not a multi-million dollar angel investor like Sheel, his lessons are applicable to the everyday person trying to invest in good companies
    • Host: Harry Stebbings (@HarryStebbings)


    Read the full notes @ podcastnotes.org



    Sheel Mohnot is a Co-Founder and General Partner @ Better Tomorrow Ventures, a $225M fund that leads rounds in pre-seed and seed-stage fintech companies globally. Sheel and Jake (his co-founder) invested for many years together before founding BTV and wrote checks into Mercury, Flexport, Ramp, and Hippo Insurance to name a few. As for Sheel, before BTV he ran 500 Fintech for close to 7 years, and before that was a founder, founding two companies, both of which were acquired. If that was not enough, Sheel is also a master at measuring the width of swimming pools and making cameo appearances in music videos with Justin Bieber.

    In Todays Episode with Sheel Mohnot We Discuss:

    1.) Entry into Venture:

    • How Sheel made his way into the world of venture having founded 2 fintech companies?
    • Why did no LPs give Sheel money in the early 500 Fintech days? What were some of his biggest lessons from investing in 100s of companies with 500 Fintech?
    • How did BTV with Jake come together most recently? What are the biggest differences to Sheel of being a fund manager vs being an investor?

    2.) The Power Law:

    • How does Sheel define "the power law" in venture capital? What multiple of return would be power law status?
    • Given the size of outcome available with these power law returns, how does Sheel approach portfolio construction? Would it not be best to invest in 100s of companies?
    • Who does Sheel believe has done the indexing approach best? Why?

    3.) Venture Capital has Never Been Less Collaborative:

    • Why does Sheel disagree with Harry that venture capital has never been less collaborative?
    • Why now, for the first time, are large multi-stage funds taking single-digit ownership?
    • Does Sheel agree with Harry it is moronic to have "guaranteed pro-rata"? How does Sheel approach re-investment decision-making? When does he pay up vs not?

    4.) The Biggest Wins and Misses:

    • What have been Sheel's biggest wins from a cashback and a multiple perspective?
    • How did Sheel miss the chance to invest in both Robinhood and Chime early on? What did he not see? How would he have thought differently with the benefit of hindsight?
    • How have Sheel's biggest hits and misses impacted how he invests today?

    5.) Emerging and Frontier Markets:

    • Does Sheel share Harry's concern for the removal of capital from emerging markets?
    • Why does Sheel believe that India, South East Asia and LATAM will be fine?
    • Why does Sheel believe Pakistan and Africa are most in trouble?
    • What advice does Sheel give to his emerging markets founders today?

    Items Mentioned in Today's Episode:

    Sheel's Favourite Book: Enders Game

    44 min
  • Mark Leslie: Silicon Valley Go-to-Market Legend (Part 1)
    During the 1990s, Mark co-founded Veritas Systems, which he piloted from nothing to 6,000 employees and $1.5B in revenue in a decade. Now a lecturer in management at the Stanford Graduate School of Business, Leslie is one of the foremost experts in go-to-market strategy in Silicon Valley, and in the first of this two-part series with Mike Maples, Jr of FLOODGATE, Leslie discusses what strategies he used to make Veritas a runaway success, and the origins for the Sales Learning Curve.
    46 min

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