• Check out the 20VC Episode Page & Podcast Notes

David Friedberg is Founder and CEO of The Production Board (TPB), a holding company established to solve the most fundamental problems that affect our planet, by reimagining global systems of production. Prior to founding The Production Board, David founded The Climate Corporation, a 10-year journey that culminated in their $930M acquisition by Monsanto. If that was not enough, David is the Founder and Chairman at Metromile and also sits on the board of Soylent, Clara Foods, Tillable, Cana Technologies and more.

1.) Origins:

• How David made his way into the world of startups and technology from academia and physics?
• What were David's biggest takeaways from scaling The Climate Corp to $930M exit to Monsanto?
• How did the exit put pressure on David for all future companies he builds? How does he manage that?

2.) The Macro: Venture + The Economy

• How does David foresee the impending rate hikes? What impact will this have on venture and the economy?
• What segment of the market will be first to be hit? Why is growth investing last to be hit? How does early stage play out in this very new environment?
• How will we see the velocity of capital deployment change in this new period? What does David believe are some of the crucial flaws of the venture model?
• How does David reflect on his own price sensitivity? What lessons has he learned from deals he has done or missed that have changed his perspective?

3.) David Frankel: The Business Builder

• What is David's rubrik for business value creation? How has this changed with time?
• How mentally plastic does one have to be around the time it takes to see margins, unit economics etc change from negative to positive?
• How does David and the team approach building new companies at TPB? Where do they find the founding teams? How do they incentivise them?
• How does TPB approach continuous funding for the companies they create? What milestones need to be hit? How do they assess them?
• How does David approach liquidity with regards to exits for the companies they create? Why does their holding company structure mean they have different incentives to VCs?

4.) David Friedberg: Father and Husband

• How does David reflect on his own relationship to money today? How has it changed over time?
• What have been David's biggest realisations on what provides him true happiness?
• How did having children change his operating mentality? What does being a great father mean to David?

David’s Favourite Book: Zen Mind, Beginner's Mind

• Check out Beginner’s Mind Episode Page & Show Notes

Did you know that almost 90% of all product ideas fail in clinical trials? The most obvious reason that a clinical trial fails is lack of efficacy.

Surprising to me was that lack of efficacy doesn't seem to be the main reason why clinical trials fail in the first place. Other factors are at play, and most of them are manageable risks when the right team is at work.

In this episode, we talk about:

• Strategic considerations for setting up a clinical trial
• Inhouse vs Outsourced Clinical Study Management
• Why do some clinical trials fail?
• Steps to getting your clinical trial back on track
• Future trends of clinical trials
• and much more

Who is the expert in the show?
Heike Schön is the Managing Director and Co-Founder of Lumis International GmbH and Lumis Life Science Consulting GmbH.

She has more than 25 years of experience in leadership positions in international clinical research and drug development.

📞 Book a meeting here: Link

Youtube: https://youtu.be/r0qphO8Qs3o
Shownotes @ Podcastnotes: tbd

Timestamps:
(00:00) Intro
(02:25) Who Is Heike Schön, Lumis International and Lumis Consulting?
(04:20) Topics in the Episode
(04:30) Kick-Off
(05:00) Background to Lumis International and Heike Schön
(10:20) When is the Right Time to Start with the Planning of a Clinical Trial?
(12:10) The Role of a Sponsor of a Clinical Trial
(14:30) Who is Responsible for the Clinical Trial as a Sponsor?
(16:55) When Should a Company Start to Implement Clinical Trial Management in the Organisation?
(18:30) Funding Requirements for Clinical Trials
(20:00) The Reality of Inhouse and Outhouse Clinical Trial Management
(22:15) What to Think About When Planning Oversight Management
(25:00) Relationship and Culture Management in Clinical Trials
(27:25) Budget and Ressource Requirement for Clinical Trials
(28: 45) 3 Steps to a Successful Clinical Trial 
(30:40) The 3 Main Reasons Why Clinical Trials Fail
(33:30) Considerations for Patient Enrollment as a Key Success Factor for Clinical Trials
(37:30) … and when enrolment fails, what are the steps to rescue the trial?
(42:45) Do Inhouse Studies Require Rescue?
(44:30) How to Rescue a Clinical Trial
(48:30) Root Cause Analysis as a Starting Point to Rescue a Trial
(52:25) Preventive Measures to Avoid Failure Early on
(53:30) How Important is Leadership in a Clinical Trial?
(56:30) The 3 Main Reasons to Stop a Clinical Trial – The Point of no Return
(59:00) How are the Cost Calculated for Rescue Study Management?
(01:00:15) Planning of a Clinical Trial – A Key Aspect of a Successful Trial
(01:02:15) How to Plan Realistic Timelines and Numbers
(01:07:15) The Role of Feasibility Studies in Clinical Trials
(01:09:30) How Clinical Trial Management Evolved in the last 30 years
(01:11:15) Upcoming Trends in Clinical Trial Management
(01:13:15) Decentralized Clinical Trials
(01:15:00) Artificial Intelligence And Big Data in Clinical Trial Management
(01:17:55) The Digital Twin
(01:19:15) The Human Factor and Leadership in Clinical Trial Management
(01:21:10) The Patient in Clinical Trials
(01:22:55) Planning and its contribution to clinical trial success
(01:26:55) Summary of What to Do When Clinical Trials Fail
(01:28:35) When is the Right Time to Add a Rescue Team to the Clinical Trial?
(01:31:00) A Risk Management Plan for Clinical Trials
(01:32:00) How to Cont

Chad Johnson is a permaculture maestro. He’s studied under Sepp Holzer and cut his teeth in the North of Minnesota where he practices a permaculture/food forest model of working with the land. He’s the man we’re working with to help work with the land in Lockhardt. We’ll run it back, but here’s an incredible intro to him and the work that he does.

Connect with Chad:

Website: www.keystoneintelligence.org 

Show Notes:

• "Desert or Paradise" Sepp Holzer

• "Sepp Holzer's Permaculture"  

• The Biggest Little Farm - Amazon

• Living 4D Ep 97 - Dr. Ibrahim Karim: BioGeometry: Profound Healing Through Ancient Wisdom and Modern Science

• biogeometry.ca/home  

• Agriculture - Rudolph Steiner 

• Regenerative Agriculture - Richard Perkins 

Sponsors:

• Qualia Mind is hands down the most balanced neurotropic I have in my arsenal right now. Head over to neurohacker.com for a month’s supply currently @ 50% off. Punch in code “KKP” for an additional 15% off everything.

• PaleoValley Some of the best and highest quality goodies I personally get into are available at paleovalley.com, punch in code “KYLE” at checkout and get 15% off everything!

• Super Speciosa is the absolute best Kratom I’ve worked with head over to getsuperleaf.com/kkp and punch in “KKP” at checkout for 20% off everything in store!

• Organifi Go to organifi.com/kkp to get my favorite way to easily get the most potent blend of high vibration fruits, veggies and other goodies into your diet! Click that link and use code “KKP” at checkout for 20% off your order!

Connect with Kyle:

Fit For Service Academy App: Fit For Service Academy 

Instagram: @livingwiththekingsburys  

Youtube: Kyle Kingbury Podcast 

Kyles website: www.kingsbu.com 

Zion Node: https://getzion.com/ > Enter PubKey 

>PubKey: YXykqSCaSTZNMy2pZI2o6RNIN0YDtHgvarhy18dFOU25_asVcBSiu691v4zM6bkLDHtzQB2PJC4AJA7BF19HVWUi7fmQ

Like and subscribe to the podcast anywhere you can find podcasts. Leave a 5-star review and let me know what resonates or doesn’t.

• Check out The Danny Miranda Podcast Episode Page & Show Notes

(0:00) Intro

(2:15) Ice hockey experience

(5:15) What made Dr. Proctor keep going?

(6:00) Meeting Olympian hockey players

(9:25) Getting recognized in public

(11:53) Almost an astronaut

(15:07) Why did Dr. Proctor’s friend suggest she apply to be an astronaut?

(16:29) How do you cultivate curiosity for new technologies?

(18:00) How did Dr. Proctor’s dad help her

(20:07) Why your self-talk is so important

(22:23) Going to Mars?

(24:30) What challenges do we face settling on Mars?

(26:16) Civilians going to space

(28:05) What should we expect on Mars?

(30:40) “Learn to be more forgiving to yourself”

(33:28) Talking to Michelle Obama

(36:58) Starship Earth

(40:49) Where does Dr. Proctor feel accepted?

(41:52) Seeker poem

(44:28) NFTs and saying yes to early technology

(50:39) Exploring the inner world

(55:49) Jack of all opportunities, master of life experience

(56:50) Nickname “Leo”

(1:00:40) Meeting Elon Musk

(1:04:16) Gryffindor

(1:06:37) Is Inspiration4 a family?

(1:08:47) Connecting with Dr. Proctor

Dr. Sian Proctor is an American geology professor, science communicator, and commercial astronaut. She was launched into Earth orbit, on September 15, 2021, as the pilot of the Crew Dragon space capsule.

I originally came across Dr. Proctor when she starred in the Netflix special Countdown: Inspiration4 Mission to Space. In this conversation, we spoke about settling on Mars, getting recognized, and her many talents + interests.

Dr. Proctor's Twitter – https://twitter.com/DrSianProctor

Space2Inspire – https://www.amazon.com/Space2inspire-Inspiration-Dr-Sian-Proctor/dp/1733765417

Continue the conversation with me... 🎙 Podcast: https://podfollow.com/1532160275

🐣 Twitter: https://twitter.com/heydannymiranda

📸 Instagram: https://instagram.com/heydannymiranda

🕺 TikTok: https://tiktok.com/@heydannymiranda

🚨 Newsletter: https://dannymiranda.com/tuesday-treasure/

• Don’t force sleep, it’s dangerous to stay awake in bed for long periods of time
  • “You’d never sit at the dinner table waiting to get hungry, so why would you lie in bed waiting to get sleepy?” – Matthew Walker
  • Pavlov’s Classical Conditioning: your brain will begin to bond a negative association with your bed and being awake
  • Target a sleep efficiency of 85%-90% (time spent in bed asleep)
• The harder you try to sleep, the harder it becomes
  • Don’t count sheep, take yourself on a long mental journey. Take your mind off of itself.
• “The snooze button is the perennial expression of the human frustration of chronic lingering sleep debt”– Matthew Walker
  • Experiment: If you regularly set an alarm clock, would you wake up at that same relative time without the alarm clock?
  • If no, you’re probably operating in a sleep deficit
• Alcohol and Caffeine before bed reduce your body’s ability to benefit from sleep
  • Alcohol is the opposite of a sleep aid, it is a sedative and sedation is not sleep
  • Try to cut off caffeine consumption 10 hours before bed
  • Continue reading for specific biological responses
• Matthew mentions some methods for combatting insomnia and sleeping better
  • Cognitive Behavioral Therapy for Insomnia (CBT-I)
  • Sleep Restriction and Behavioral Therapy for Insomnia
  • How to Determine Your Chronotype and Ideal Sleep Schedule

Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/

Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/

Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

How does behavior affect your biology? What does neuroscience say about hypnosis, breath work, and meditation? Are behavioral tools more powerful than pharmaceuticals in changing your state and focus?

Today we dig into these big questions and more with neuroplasticity overlord Dr. Andrew Huberman, back for a second, highly anticipated return to the show.

Given that Dr. Huberman’s first appearance on the podcast (RRP #533) has amassed over 10 million views on YouTube alone, chances are you’re already familiar with this tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine, where he runs The Huberman Lab, which studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance.

Subsequent to our first podcast in January of 2021, Andrew launched The Huberman Lab Podcast, which has quickly become a sensation. Within a year of launch, it has ascended to one of the top, most listened to podcasts in the world.

Today we pick up where we last left off, diving deep into a wide array of fascinating topics brimming with actionable takeaways, including:

• the emerging field of mind-body neuroscience;
• the neuroscience of ADHD, focus, hypnosis, and processing trauma;
• how to leverage light, temperature, breath, and sleep to better control your biology;
• several behavioral tools for achieving optimal performance states;
• how to cultivate learning states and the power of something called gap effects; and
• many other fascinating topics

To read more, click here. You can also watch it all go down on YouTube. And as always, the podcast streams wild and free on Apple Podcasts and Spotify.

Andrew is a passionate man with an incredible facility for communicating complex scientific topics in a uniquely compelling and understanding way.

For those keen on understanding how to better control your mind, neurochemistry, and all told biology—consider this episode appointment listening.

SCIENCE!

Peace + Plants,

See acast.com/privacy for privacy and opt-out information.

• Check out The Unraveling Podcast Episode Page & Show Notes
• Disclaimer: There is no doubt that Putin is the aggressor and is doing terrible things to the Ukrainian people. However, there is a long interwoven history of US misadventures abroad that shouldn’t be forgotten.

Jocko and Darryl welcome special guest Scott Horton. Scott is the director of the Libertarian Institute, and the senior editor of antiwar.com. He's also an author of books such as Fool's Errand: Time to End the War in Afghanistan, and Enough Already: Time to End the War on Terror.