What’s it like to run a startup that has achieved its goal of impacting humanity at a time of desperate need? Moderna CEO Stephane Bancel joins Mike Maples, Jr of FLOODGATE to discuss the power of taking offensive risks to seize unlikely futures with massive upside, sometimes with the result of changing the odds of life itself. For founders seeking greatness, the conversation also teases out many of the enduring lessons of how we can increase the odds of creating massive breakthroughs.

LIMITED-TIME OFFER: Go to wander.com/kyle, download the app and create an account to enter to win a free Wander Trip and you can also become a Wander Founding Member for $100 and unlock benefits like:

* Get $100 credited toward your first stay

* Limited edition founding member hoodie

* Early access to Wander Homes before everyone else

* A potential opportunity to invest in the company

For episode #19, I chatted with John Andrew Entwistle, founder and CEO of Wander.com, about the challenges of starting and scaling companies, building the future of life, work and travel, cultural pitfalls in early-stage startups, the importance of writing down life lessons and how immigrants can save America. Prior to starting Wander, John Andrew was the CEO and Co-Founder of Coder.com, on the Forbes 30 under 30 list and a Thiel Fellow.

This is a very special episode because a few weeks back I announced that I joined Wander’s founding team as CMO after initially investing in the company back when Wander was just John Andrew, an idea and an incredible domain. You might be wondering – what is Wander? It’s a network of smart homes in inspiring places that you can book for you next workcation, vacation or anything in between and control every aspect of the experience from your smartphones — from unlocking the door to setting the temperature to turning on the fireplace to adjusting lights and even accessing the Tesla in the garage. Our approach is entirely different from traditional travel options because we own and operate 100% of the homes on our platform and we believe that by owning both the bits and the atoms we can deliver a truly superior guests experience.

We just launched last week and want our early believers to join us on the ground floor. For a short period of time, you can become a Wander Founding Member for $100 and unlock benefits like:

* Get $100 credited toward your first stay

* Limited edition founding member hoodie

* Early access to Wander Homes before everyone else

* A potential opportunity to invest in the company

We’re also giving away a free Wander Trip for you and up to 3 friends for 3 nights. Just go to wander.com/kyle download our app and create an account to enter for free. This episode is a little different than most in all the right ways. I hope you enjoy this conversation with John Andrew Entwistle.

Overthink

✓

Claim

Podcast Notes Key Takeaways

• The practice of hooking up raises a lot of philosophical questions related to feminist theory, queer theory, and ethics
• The philosopher James Rocha defines a hookup as a sexual encounter by two people not in a committed relationship
• Theroots of the hookup culture can be traced to the rise of fraternities in American universities in the mid-1800s and the rise of women liberation movements in the early 20th century
• In recent decades, women have been encouraged to pursue their sexual desires more openly. They are rejecting the purity culture
• “In a sense, what hook up culture does is extend the traditionally masculine form of sexual activity to women” – Ellie Anderson
• There is a strong feeling of pressure to compete in the hookup culture, or what Lisa Wade calls “the erotic market place”
• The hookup culture is unforgiving to those who are excluded from the “market” due to cultural or religious differences, or low social capital
• Hookup culture’s norm of “radical casualness” undermines basic human decency
• “I think I would like to see a future where we move towards much more anarchic, respectful, and ambiguous ways of engaging in casual sex that doesn’t have the kind of contradictions endemic to the idea of hooking up”– EllieAnderson
• Because there is no end goal, hooking up is a form of resistance towards the logic of nuclear family; first love, then marriage (What Lauren Berlant calls a love plot)

Read the full notes @ podcastnotes.org

Hooking up: sexual liberation or unethical exploitation? With the rise of dating apps, sexual gratification seems like a few taps (or swipes) away at any given moment. What implications does this have for sexual ethics around consent, fantasy, and using other people merely for pleasure? In this episode, Ellie and David dive into the history, theory, and criticisms of hookup culture. Is there a way to hook up ethically? Some argue that the power imbalances fundamental to hooking up prevent it from ever being on equal grounds, yet others claim that the shift to hooking up generates potential for queer exploration and for sexual discretion in ways that were previously unavailable. Let’s find out!

Works Discussed

F Boy Island (TV Show)
James Rocha, The Ethics of Hooking Up
Danielle M. Currier, “Strategic Ambiguity: Protecting Emphasized Femininity and Hegemonic Masculinity in the Hookup Culture”
Lisa Wade, American Hookup
Lisa Wade and Joseph Padgett, “Hookup Culture and Higher Education”
Lisa Rudd, “Beyond the Closet”
Lee Edelman, No Future
Slavoj Žižek, A&F Quarterly, Back to School Issue 2003
Leo Bersani, Is the Rectum a Grave?

Website | overthinkpodcast.com

Instagram & Twitter | @overthink_pod

Email |  [email protected]

YouTube | Overthink podcast

Huberman Lab

Podcast Notes Key Takeaways

• To improve mood and optimize sleep-wake cycle: view light in the morning and as much as possible during the day
• Three components to get in order: mealtimes, light exposure, and sleep
• Key is doing self-exploration to find ideal timing of meals, light exposure, and sleep that align with circadian rhythm – start by manipulating light exposure because that’s the most powerful driver of the other pieces
• Daylight saving has a negative impact on sleep & wake cycles – it’s not just an hour per day, it’s a cumulative effect on the rhythm
• Evening light exposure impacts sleep! Keep your home dim/dark. Keep to the minimum amount of light you need to see comfortably; explore using red light
• The more we deviate from intrinsic rhythm, the more we see increased rates of depression, anxiety, adverse mental health outcomes
• Light viewing and feeding behavior interact in ways that support one another: keep feeding times to most active points in circadian rhythm (i.e., during light)

Read the full notes @ podcastnotes.org



In this episode, I host Dr. Samer Hattar, Chief of the Section on Light and Circadian Rhythms at the National Institute of Mental Health. Dr. Hattar is a world-renowned expert on how viewing light at particular times adjusts our mood, ability to learn, stress and hormone levels, appetite, and mental health. We discuss how to determine and use your individual light sensitivity to determine the optimal sleep-wake cycle for you. We also discuss how to combine your light viewing and waking time with the timing of your food intake and exercise in order to maximize mental and physical functioning. Dr. Hattar is credited with co-discovering the neurons in the eye that set our circadian clocks and regulate mood and appetite. He explains why even a small shift in daylight savings leads to outsized effects on our biking because of the way that our cells and circadian clocks integrate across many days. And he offers precise tools to rapidly adjust to jetlag, shift work, and reset your clock after a late night of work or socializing. This episode is filled with cutting-edge data on the biological mechanisms of human physiology and practical tools for people of all ages. 

 

Thank you to our sponsors:

• ROKA - https://www.roka.com -- code: "huberman"
• InsideTracker - https://www.insidetracker.com/huberman 
• Magic Spoon - https://www.magicspoon.com/huberman 

 

Support Research in Huberman Lab at Stanford:

• https://hubermanlab.stanford.edu/giving

 

Our Patreon page:

• https://www.patreon.com/andrewhuberman 

 

Supplements from Thorne:

• http://www.thorne.com/u/huberman 

 

Social:

• Instagram - https://www.instagram.com/hubermanlab 
• Twitter - https://twitter.com/hubermanlab 
• Facebook - https://www.facebook.com/hubermanlab 
• Website - https://hubermanlab.com 
• Newsletter - https://hubermanlab.com/neural-network 

 

Samer Hattar:

• Twitter: https://twitter.com/samerhattar 
• Instagram: https://www.instagram.com/samerhattar 
• Wikipedia: https://en.wikipedia.org/wiki/Samer_Hattar 

 

Links:

• Graphical Explanation of Temperature Minimum for Overcoming Jetlag - https://www.instagram.com/tv/CKWiRVJHVwC

 

Timestamps:

• 00:00:00 Introducing Dr. Samer Hattar, Ph.D.
• 00:02:17 Sponsors: ROKA, InsideTracker, Magic Spoon
• 00:06:15 Light, Circadian (24 hour) & Circannual (365 day) “Photoentrainment” 
• 00:14:30 Neurons in Our Eyes That Set Our Body Clocks: Similar to Frog Skin
• 00:18:55 What Blind People See 
• 00:20:15 When, How & How Long to View Light for Optimal Sleep & Wakefulness
• 00:30:20 Sunlight Simulators, Afternoon Light Viewing, Naps
• 00:33:48 Are You Jetlagged at Home? Chronotypes & Why Early Risers Succeed 
• 00:38:33 How to Decide Your Best Sleep-Wake Schedule; Minimal Light Test
• 00:42:16 Viewing Light in Middle of Day: Mood & “Light Hunger”
• 00:44:55 Evening Sunlight; Blueblocker Warning
• 00:48:57 Blue Light Is Not the Issue; Samer’s Cave; Complete Darkness
• 00:53:58 Screens at Night
• 00:56:03 Dangers of Bright Light Between 10 pm and 4 am: Mood & Learning
• 01:01:05 The Tripartite Model: Circadian, Sleep Drive, Feeding Schedules
• 01:05:05 Using Light to Enhance Your Mood; & The Hattar-Hernandez Nucleus
• 01:07:19 Why Do We Sleep?
• 01:08:17 Effects of Light on Appetite; Regular Light & Meal Times
• 01:18:08 Samer’s Experience with Adjusting Meal Timing
• 01:22:51 Using Light to Align Sleep, Mood, Feeding, Exercise & Cognition
• 01:30:15 Age-Related Changes in Timing of Mental & Physical Vigor  
• 01:31:44 “Chrono-Attraction” in Relationships; Social-Rhythms
• 01:33:40 Re-setting Our Clock Schedule; Screen Devices Revisited
• 01:37:50 How Samer Got into the Study of Light 
• 01:39:33 Clock Gene mRNAs & More Accurate Biomarkers
• 01:41:08 Light as Medicine
• 01:42:48 ADHD (Attention-Deficit Hyperactivity Disorder) 
• 01:43:35 How to Beat Jetlag: Light, Temperature, Eating
• 01:50:44 Vigor: The Consequence of Proper Timing 
• 01:52:15 Waking in the Middle of the Night: When Your Nightly Sleep Becomes a Nap
• 01:54:10 Melatonin, Pineal Calcification
• 01:55:25 Our Seasonal Rhythms: Mood, Depression, Lethargy & Reproduction
• 01:59:08 Daylight Savings: Much Worse Than It Might Seem 
• 02:05:27 Eye Color & Sensitivity to Light, Bipolar Disorder
• 02:09:28 Spicy Food, Genetic Variations in Sensory Sensitivity 
• 02:10:52 Synthesizing This Information, Samer on Twitter, Instagram
• 02:13:00 Conclusions, Ways To Support the Huberman Lab Podcast & Research

 

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

 

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

The Danny Miranda Podcast

Podcast Notes Key Takeaways

• We are rarely shocked by innovation anymore; we adapt incredibly fast to technological advances
  • Continue to pay attention to these changes and be shocked when appropriate, you never know how the value of simply paying attention will come to fruition
• “Synchronicities are our signposts. The more you notice, the more you see.” – Akira The Don
  • Immerse yourself in your craft and quadruple down on your passion; your work will start to work for you if you let it
    • Thoughts become things – The more you learn, the more opportunities reveal themselves
    • Reverse engineer your goals – set up systems that you know will guide you towards your goal
• Blockchain reverts back some original ideas of the internet that got killed off
  • You make money on subscriptions rather than advertising
  • You used to own your own website, not operate under a provider
• “We are at the point in the game where we have to dream up the new shit” – Akira The Don
  • Sci-fi movies are not that far off from reality, it’s time to take the next step with ideas
  • Akira calls it the Neo-Psychedelic Sci-Fi Age
• Your challenges are your adventures and your journey, life’s truly magical when you have the perspective that all of this is building into one great story

Read the full notes @ podcastnotes.org

Akira The Don is a musician and DJ. He is the creator of MEANINGWAVE.

In this conversation, we spoke about Akira's childhood, how the world switches every 7 years, and how he's managed to stay at the forefront of new trends.

Akira The Don Links

Website / Twitter / Instagram / YouTube

Continue the conversation with me...

Twitter / Instagram / YouTube / TikTok / Website

Author and psychologist Paul Bloom of the University of Toronto talks about his book, The Sweet Spot, with EconTalk host Russ Roberts. Bloom argues that suffering is underrated--suffering is part of happiness and meaning. This is a wide-ranging discussion of popular culture, religion, and what we hope to get out of life.

Carl Hart is a psychologist at Columbia University. Please support this podcast by checking out our sponsors: – InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off – Ten Thousand: https://www.tenthousand.cc/ and use code LEX to get 15% off – Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Carl’s Twitter: https://twitter.com/drcarlhart Carl’s Website: https://drcarlhart.com Drug Use for Grown-Ups (book): https://amzn.to/3lVpq2Y PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT

Impact Theory with Tom Bilyeu

Podcast Notes Key Takeaways

• “Without doing hard things we will go backward in life” – James Lawrence
• You cannot read about climbing a mountain, you need to have that experience for yourself
• Momentum is important; by doing you are creating small wins in your path
• Many people want to go from “0 to 100”, and then they fail
  • The solution is in the process, in between the “0 to 100”
• By doing hard and uncomfortable things and pushing through them, you:
  • Learn your weaknesses
  • Find defense mechanisms; your “why” – the most useful tool
• Learning and dealing with the negative voice inside your head is the most important lesson
  • After doing this for 15 years, James Lawrence is still hearing the internal “bully”
• Big goals are important, but being present at every step of the journey is the most important aspect
  • Before you go on any journey in your life, figure out what you stand for (your ethos)
• The human body is an amazing tool, it can go from bad to great and vice versa in 24 hours
  • “We don’t know what tomorrow is going to bring” became the theme of the Conquer 100

Read the full notes @ podcastnotes.org

Check out our sponsors: 

Athletic Greens: Go to athleticgreens.com/impact and receive a FREE 1 year supply of Vitamin D AND 5 free travel packs with your first purchase!

Stay updated on our special NFT product drop coming October 13, 2021! Join the Impact Theory Discord channel or follow Tom on Twitter for updates: Discord: https://impacttheory.com/discord Twitter: https://twitter.com/TomBilyeu

ButcherBox: Sign up at ButcherBox.com/impact and get 2 lbs of ground beef FREE in every order for the life of your membership.

Helix Sleep: Go to HelixSleep.com/impact for up to $200 off your mattress and 2 free pillows.

MindPump: mindpumpimpact.com

Skillshare: Explore your creativity at skillshare.com/impacttheory for a 1 month FREE trial of Premium Membership.

When you sit back allow yourself to really dream, often the dream you have is beautiful but it’s also big, a little scary, and intimidating. Big dreams and big goals feel nearly impossible. It’s hard to fathom how you’re supposed to get from where you are in this moment to this far away goal that’s hard to conceptualize. James “Iron Cowboy” Lawrence completed 50 consecutive Iron-Distance Triathlons covering 7,030 miles with 0.24% of those miles completed indoors due to inclement weather. He joins Tom and breaks down the backlash he got for doing less than 17 miles indoors, and reveals the real mental fortitude and personal challenges he faced that lead him to deciding on completing 100 consecutive Iron-Distance Triathlons this time, plus one.

 

James talks about what it really means to do hard things, and how the secret of achieving your goals is in the journey, the failures, and the lessons that prepare you for the actual goal. He’s opening up about what his post-recovery has become and the challenges he’s overcoming for that as well.

 

Order the Iron Cowboy’s book, Redefining Impossible: https://amzn.to/3k4XhFQ

Check out James’ 1st Interview with Tom, Push Past Pain: https://youtu.be/cgU7abzvSQk

 

SHOW NOTES:

 

1:02 | Why Do the Hard Things

7:10 | 100% Physical & 100% Mental

13:56 | Goals Change Perspective

20:08 | Confront Your Weakness

24:59 | 101 Iron-Distance Triathlons

42:10 | Set Your Own Standards

52:57 | Why Do 1 More Than 100

58:37 | Post-Recovery Stage

 

QUOTES:

 

“Doing hard things with intent is preparation for the unknown.” [2:18]

 

“Motion creates emotion, and you have to experience something and feel it in order to have an experience or knowledge with it.” [4:00]

 

“Mastering that continual conversation and beatdown that we have with ourselves is one of the most important pieces to that puzzle.” [9:42]

 

“Why people fail is because they rush straight to that big goal and they miss out on everything in between, which is the most important part.” [14:48]

 

“You need to meet yourself where you're at, on your journey. And over time, your perception perspective will change about what's possible for you.” [18:20]

 

“You wouldn't do something if you knew how damn hard it was going to be, and you wouldn't do something if you had all the answers, and you don't start as the expert.” [34:34]

 

“What you say you're going to do is the expectation, and if you deviate from that, it gives them permission to then attack you.” [43:23]

 

“We don't know what tomorrow is gonna bring, and if you quit now you're never going to find out and that would be the most tragic thing you do on your journey…” [49:46]

 

Follow James Lawrence:

Website: https://www.ironcowboy.com/

Twitter: https://twitter.com/IronCowboyJames

Facebook: https://www.facebook.com/IronCowboy/

Instagram: https://www.instagram.com/ironcowboyjames/

 

Corporate Machiavelli is an anonymous Twitter account and blog, in this episode, we spoke about the idea behind his account. On leaving all his information behind as a legacy due to being terminally ill. A mind-opening episode on things you can do to rise up in the modern world, and ways you should live your life. Twitter: @CorporateMach Blog: www.Corporatemachiavelli.com --- This episode is sponsored by · Anchor

Huberman Lab

Podcast Notes Key Takeaways

• Top three things that support nerve health in the short and long term: EPA, phosphatidylserine, choline
• To condition healthy food preferences: take something good for you, pair it with something that will increase blood sugar (not spike, but elevate slightly) for 7-10 days to rewire the dopamine reward system
• Food impacts our brain and health but there’s also a learned response to how our brain functions in response to foods
• Some foods to enhance short and long term cognition: fish, blueberries, eggs, cottage cheese, cabbage
• The goal is to get proper nutrients via food; use supplements as a backup as needed
• Start feeding window at least one hour after waking and end the window about 2-3 hours before sleep
• Keep feeding window consistent day to day without extreme shifts in either direction

Read the full notes @ podcastnotes.org

This episode I describe science-supported nutrients for brain and performance (cognition) and for nervous system health generally.

I describe 10 tools for this purpose, including specific amounts and sources for Omega-3 fatty acids which make up the "structural fat" of neurons (nerve cells) and allow them to function across our lifespan. I also review data on creatine, phosphatidylserine, anthocyanins, choline, glutamine and how they each impact brain function in healthy people seeking to reinforce and improve their cognition and in those combatting cognitive decline. I describe both food-based and supplement-based sources for these compounds, and their effective dose ranges based on peer-reviewed literature.

Then I review the 3 factors: gut-brain signaling, perceived taste, and learned associations that combine with the metabolic and blood-sugar-elevating effects of food to determine what foods we seek and prefer. Amazingly, it's not just about what tastes good to us. Next, I explore how we can leverage the neural circuits of learned food preference toward seeking and enjoying the right foods for brain health and performance. I also review new data on non-caloric sweeteners and why consuming them with glucose-elevating foods can be detrimental,  in some cases rapidly leading to insulin dysregulation. This episode covers more than 10 actionable tools for those seeking to improve and/or maintain brain function, and it explains modern neuroscience underlying of our sense of taste, our food seeking preferences and brain metabolism.

 

Thank you to our sponsors:

• ROKA - https://www.roka.com -- code: "huberman"
• InsideTracker - https://www.insidetracker.com/huberman
• Headspace - https://www.headspace.com/specialoffer 

 

RETHINK EDUCATION: The Biology of Learning Featuring Dr. Andrew Huberman:

• https://youtu.be/Oo7hQapFe3M 

 

Our Patreon page:

• https://www.patreon.com/andrewhuberman 

 

Supplements from Thorne:

• http://www.thorne.com/u/huberman 

 

Social:

• Instagram - https://www.instagram.com/hubermanlab 
• Twitter - https://twitter.com/hubermanlab 
• Facebook - https://www.facebook.com/hubermanlab
• Website - https://hubermanlab.com
• Newsletter - https://hubermanlab.com/neural-network 

 

Links:

• Review on Anthocyanins & Cognition - https://www.mdpi.com/1420-3049/24/23/4255 
• Review on Creatine & Brain Health Studies - https://www.mdpi.com/2072-6643/13/2/586 
• Review on "Rethinking Food Reward" - www.annualreviews.org/doi/10.1146/annurev-psych-122216-011643 

 

Timestamps:

• 00:00:00 Food & Brain Function Introduction
• 00:02:08 Summary: Critical Aspects of Time Restricted Feeding/Fasting
• 00:04:19 Sponsors: ROKA, Athletic Greens, Headspace
• 00:08:24 Neuroplasticity Super Protocol (Zero-Cost Tools) Online
• 00:09:22 Eating to Enhance Brain Function & Foundational Aspects of Brain Health 
• 00:13:00 Eating Fats for Brain Health, EFAs Phospholipids (Tool 1: 1-3g EPA Omega-3/day) 
• 00:20:35 Phosphatidylserine (Tool 2: 300mg/day)
• 00:22:15 Choline, Egg Yolks (Tool 3: 1-2g/day Threshold)
• 00:28:26 Hydration & Electrolytes (Tool 4)
• 00:29:50 Liquid Fish Oil/Capsules (2-3g EPA per day; 300mg Alpha GPC 2-4X/week)
• 00:32:22 Creatine for Cognition (Tool 5: 5g/day) 
• 00:36:28 Anthocyanins, Dark Skin Berries (Tool 6-10mg/day (Extract), 1-2 cups Berries) 
• 00:41:19 L-Glutamine (Tool: 1-10g/day) & Offsetting Apnea & Inflammation
• 00:49:23 Neural Basis of Food Preference, Yum, Yuck, Meh; Taste, Guts, & Beliefs
• 00:55:25 Taste is 100% In your Head
• 00:59:50 Gut Neurons Controlling Food Preference: Neuropod Cells; (Tool 7: Fermented Foods) 
• 01:06:14 Capsule Probiotics, Brain Fog 
• 01:07:16 Learning to Like Specific Tastes: Sweetness & Brain Metabolism
• 01:12:11 Hard-Wiring & Soft-Wiring
• 01:13:25 Artificial & Non-Caloric Sweeteners: Safe or Harmful Depends on (Glucose) Context
• 01:18:15 Non-Caloric Sweetener & Insulin; (Tool 8: Don’t Have w/Glucose Elevating Foods)
• 01:22:17 Beliefs & Thoughts; The Insula; (Tool 9: Pairing-Based Reshaping Food Preferences) 
• 01:30:42 Liking Neuro-Healthy Foods & Bettering Brain Metabolism (Tool 10); Food Wars
• 01:36:05 Food Reward & Diabetes, Obesity; Important Review Article (See Caption)
• 01:38:28 Synthesis, Zero-Cost Support, Future Topic Suggestions, Sponsors, Supplements

 

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

 

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com