In this episode, Dr. David Jockers and Dr. David Perlmutter explore the root causes of Alzheimer’s and cognitive decline, focusing on metabolic dysfunction rather than amyloid plaques. Dr. Perlmutter explains how insulin resistance and metabolic disturbances contribute to neurodegeneration.

 

They dive into the role of elevated uric acid in brain health and its connection to dementia and Alzheimer’s risk. Dr. Perlmutter shares actionable steps to manage uric acid levels and improve cognitive function through diet and lifestyle changes.

 

Learn how to support brain health by balancing blood sugar, nourishing gut bacteria, and incorporating healthy fats. Dr. Perlmutter offers insights on the foods and habits that protect your brain from decline.

 

In This Episode:

• 00:00 Understanding Uric Acid and Its Impact

• 03:12 Interview with Dr. David Perlmutter

• 05:00 The Rise of Alzheimer's Disease

• 06:08 Challenges in Alzheimer's Treatment

• 07:36 Metabolic Factors in Alzheimer's

• 11:44 Lifestyle Choices to Prevent Alzheimer's

• 16:42 Key Lab Markers for Cognitive Health

• 24:55 The Role of Uric Acid in Metabolic Diseases

• 32:10 Understanding Digestive Issues: The Role of Stomach Acid

• 34:04 Uric Acid and Its Impact on Health

• 34:59 Fructose, Diet, and Metabolic Health

• 41:31 The Role of Nitric Oxide in Health

• 44:53 Dietary Recommendations for Cognitive Health

• 54:47 Daily Routine and Lifestyle Tips

• 58:32 Final Thoughts and Empowerment

 

 

Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order.

Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.

 

 

 

"Alzheimer’s is not a disease of beta amyloid; it’s about brain metabolism and glucose utilization."

~ Dr. Jockers

 

 

Subscribe to the podcast on:

Apple Podcast

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Resources:

• Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS

• Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS

 

 

Connect with Dr. David Perlmutter:

• Website: https://drperlmutter.com/

 

 

Connect with Dr. Jockers:

• Instagram – https://www.instagram.com/drjockers/

• Facebook – https://www.facebook.com/DrDavidJockers

• YouTube – https://www.youtube.com/user/djockers

• Website – https://drjockers.com/

 

 

If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/