Kashif Khan discusses Functional Genomics with Dr. Ben Weitz.
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Podcast Highlights
4:12 Genetics vs Functional Genomics. The difference between genetics and functional genomics is that genetics might tell us here’s what this gene does and we’ll speak about it independently. For example, when it comes to methylation, you might say that you have the MTHFR gene and you need to take folate is genetics. Functional genomics looks at how the body actually works and recognizes that methylation is one part of phase two of detoxification. There is also glutathionization, glucuronidation, and antioxidation. There’s all these detox functions happening in the body. And if I don’t pair them, I haven’t understood the full cascade. What does my body do from the point that a toxin enters to the point that it gets out? So first understand that, and there’s not one gene that does every single step along the way. There’s multiple processes. When you connect them and you have your full functional answer, you can then solve the problem fully also.
5:39 Kashif made an appearance on Ari Whitten’s Energy Blueprint and Ari asked if a woman has the BRCA gene should she have her breasts cut off? The genetic answer is yes, but that is because pure genetics is pharma and disease backwards. If you have the genetics and you ask why are you waiting to treat the disease, then you would remove the breasts. If you ask the wrong question, you get the wrong answer. But instead, if you ask why does the disease happen in the first place? You understand that BRCA doesn’t cause cancer. BRCA is actually a tumor suppressor and when you have breast cancer, BRCA is supposed to come along and fix it. And if you have the wrong version, you just have a bad repair tool. So you’re more likely to die from breast cancer because you can’t come back from it. So we’re solving the wrong problem once again. Why did the cancer happen to begin with? That question is better answered by looking at if the woman is estrogen dominant and does she make a lot of estrogen? Also, how does she metabolize her estrogen, which can be analyzed with DUTCH testing that measures which pathway the body uses to metabolize estrogen–the 2, the 4, or the 16 hydroxyestrogen pathway, with the 2 being healthiest and 4 and 16 being more toxic. Bad genes do not equal disease. You also have to look at diet, lifestyle, and environmental exposures. This woman’s bad choices may be that she goes on the birth control pill for 10 years that elevates her estrogen level. Then she goes on Bioidentical Hormone Therapy (BHRT). Not that you shouldn’t go on BHRT, but if you take the wrong form of estrogen and if you cook with a teflon pan and use conventional cleaning chemicals and get exposed to pesticides on her lawn that fuel the 4-hydroxy pathway. Why do we see breast cancer more commonly around the menopause age? It is because at that age, you no longer have a menstrual cycle and you no longer have the ability to get rid of this toxic load that you’re making every month. And your body stores it in fat, such as in your breasts, to protect you because it doesn’t want your organs and your vasculature getting damaged. This reduces potential inflammation in the arteries, but it leads to inflammation in the breasts and you may get cellular degradation, mutation, and eventually cancer. And if you have the wrong version of BRCA, you’re not going to fight the cancer so well.