Siim Land Podcast

Dr. Alexis Ortega is board-certified in longevity, regenerative and aesthetic medicine. He has a clinic Ad Astra in Barcelona, Spain.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:55 How to counteract age-related loss of facial harmony aside from just wrinkles

12:30 Does growth hormone change the face

18:10 Bon Charge sponsorship

19:17 What's the minimum effective dose of at-home skincare — the three things that actually move the needle?

21:28 Retinoids

24:05 Skin barrier support

27:00 Effect of sun exposure on extrinsic skin aging

31:02 Best evidence-based sunscreen ingredients

34:34 List of best sunscreen ingredients

36:00 Worst sunscreen ingredients

37:45 Daily sunscreen vs using the UV index as a guide

39:43 Do people overuse skincare products

42:33 Castor oil, beef tallow and egg yolks for skin

49:08 Are natural sunscreens effective

49:59 If someone had unlimited money today, what are the most promising rejuvenation interventions actually available?

51:08 What diagnostics Alexis would do with an unlimited budget

54:30 Rejuvenation therapies Alexis would do

55:18 Alexis approach to peptides

56:00 Intravenous senolytics

56:20 NAD injections

57:14 What you can do now to practically extend lifespan

59:40 Intravenous exosomes

01:00:25 Therapeutic plasma exchange

01:03:06 Stem cell therapy

01:05:30 Gene therapies

01:07:48 What biomarkers matter most for predicting long-term health

Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/

Dr. Kevin Perez is a computational biologist working at the cutting edge of aging science and drug discovery. His work focuses on aging research, drug repurposing, and integrating complex multi-omics data to better understand how we can extend healthspan.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:47 Kevin’s study about pharmaceuticals that are associated with reduced mortality

10:17 Which class of drugs had reduced mortality

13:07 Bon Charge sponsorship

14:12 How Kevin researches longevity molecules

16:37 Estrogen’s longevity effects

17:37 How Kevin started researching dog aging

25:32 Chemical reprogramming

29:32 Kevin’s understanding of what causes aging

34:52 Metformin vs SGLT2 inhibitors

38:37 Erectile dysfunction drugs

43:02 Over the counter supplements with longevity effects

45:52 Biological age clocks

50:02 What Kevin thinks is the best biomarker of aging

54:32 Composite biological age vs combination of multiple markers

59:32 Kevin’s new study plans

01:02:52 What Kevin wishes he adopted sooner

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY Community: https://www.skool.com/longevity-society

Timestamps:

00:00 Intro

00:37 Why Brad crowd funded a rapamycin trial

03:22 What Brad’s rapamycin trial found

12:57 Why rapamycin blunted the effects

17:17 Rapamycin effects on grip strength

19:57 Rapamycin and immune effects

21:47 Effects on biomarkers

25:22 Brad’s thoughts on rapamycin moving forward

31:52 Metformin exercise effects

32:52 Other medicines with longevity potential

36:37 Medicines that move the needle the most for people

45:17 Will Brad do another study

48:27 Brad on GLP-1s

Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield

Bloodwork for longevity panel discussion: https://youtu.be/7QONBQCpRJ0

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

Dr. Greg Potter has a PhD from the University of Leeds in sleep, nutrition, and metabolism.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:45 Catchup

02:05 Are circadian rhythms nature or nurture

09:55 What’s ideal timing of sunlight exposure for circadian anchoring

15:25 Bon Charge sponsorship

20:30 Does creatine increase DHEA or DHT levels

25:50 Does creatine reduce sleep quality

33:25 Greg’s new podcast

36:15 Is more REM sleep better

42:05 How to optimize REM sleep

44:25 What % of different sleep cycles should we get (light, deep, REM)

46:10 Is food processing good or bad

52:45 Incline bed therapy

55:20 Is it bad to use sleep herbs

58:45 Does melatonin supplementation stop natural production

01:01:15 What to do if you wake up at night and can’t fall back asleep

Greg Potter YouTube Channel: https://www.youtube.com/@gregpotterphd

Dr. Andrew Hill has a PhD in Cognitive Neuroscience from UCLA and has extensive experience in the field of neurofeedback and QEEG. He founded the Peak Brain Institute.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:45 — Andrew's new book Gifted and Tortured

04:47 — Diagnosis vs resource-based brain optimization

06:20 — The 12 core brain phenotypes

07:57 — The stabilizer and supervisor: executive and sleep control

10:23 — CEO and lifeguard phenotypes: hyperfocus, anxiety, and stuck thoughts

12:41 — Language and auditory processing phenotypes

14:53 — Bon Charge sponsorship

16:00 — Phenotypes exist on a spectrum

17:03 — Brain speed, memory, aging, and sleep-related brain fog

20:15 — Interventions: sleep, meditation, supplements, and neurofeedback

21:46 — The most common phenotypes Andrew sees

26:30 — Supplements, stimulants, and nootropics

29:24 — Why Andrew prefers training the brain over relying on meds

32:26 — How accurate is self-diagnosis?

35:12 — Sleep trackers, self-awareness, and measuring how you feel

36:11 — Peak performance and flow states

41:19 — Using phenotype to train smarter and recover better

42:34 — Siim’s brain scan begins

44:40 — What the brain map shows: fatigue, hyperfocus, and executive traits

48:57 — Siim’s speed and focus test results

53:20 — Andrew’s own brain phenotype and ADHD story

58:20 — Can focus be trained?

01:03:18 — Main takeaway: understanding your brain creates agency

Dr. Andrew Hill YouTube channel: https://www.youtube.com/@DrHillMy 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Professor Kristen Hawkes is a pioneering anthropologist whose work helped bring the grandmother hypothesis to the spotlight of human evolution research. Through fieldwork and evolutionary theory, she argued that older women may have played a crucial role in shaping the human life course, not just by living longer, but by helping feed and support grandchildren. That idea helped reframe menopause, longevity, and family cooperation as possible drivers of what makes humans distinct and what explains our longer lifespans.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

01:05 How Kristen started to think about the paradox of grandmother longevity

09:15 What accounts for variation in adult mortality across lifespan

13:40 Difference in male and female longevity

17:20 Why human babies are very dependent

20:05 Bon Charge sponsorship

21:10 Dynamics of human social evolution and longevity

23:05 How longer weening period in human babies contributes to our intelligence

29:35 Weening and intelligence

34:25 Evolutionary explanation for grandparents

36:35 The contribtion of hunting success vs gathering to children size in Hadza

47:05 Does the grandmother hypothesis make sense

48:15 Role of DHA and seafood in human brain evolution

51:35 Social hierarchy of grandparents in the Hadza

56:01 Grandfathers

01:08:35 Role of grandparents in the modern world

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

Dr. Uri Alon is a physicist-turned-biologist, a professor at the Weizmann Institute, and one of the leading thinkers exploring how complex biological systems work. In this episode, we discuss his research on the effects of genetics, lifestyle, environment, and luck on human lifespan.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:55 How big of a role does genetics play in longevity

06:25 How important is lifestyle vs genetics

08:25 How big of a role does lifestyle play in longevity

12:55 Why is lifestyle less impactful than genetics

15:25 Bon Charge sponsorship

16:30 Genes of people who live to 110

18:55 Why lifestyle matters a lot if you have bad genes

21:45 What leads to aging

22:45 What’s the maximum human lifespan

25:20 Why nobody has lived over 122 yet

27:05 Strategies to extend lifespan beyond normal

34:05 What made Uri interested in longevity as a physicist

36:25 Recurring patterns in human longevity and aging

38:40 Simplest analogie for aging

49:15 Surprising role of luck in longevity

54:55 How to practically extend your lifespan

59:30 What Uri needs to discover next about aging

Dr Uri Alon Lab YouTube channel with Systems Aging courses: https://www.youtube.com/@alonlab9733/videos

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

Timestamps:

00:00 Intro

00:36 Lifestyle bracket

06:50 Lifestyle bracket winners

11:47 Join my online community

18:46 Medicine / pharmaceutical bracket

19:20 Medicine /pharmaceutical bracket winners

22:32 Geroscience bracket

33:13 Geroscience winners

35:00 Biohacking bracket

40:16 Biohacking bracket winners

43:04 Final 8 winners

46:32 Final 4 winners

49:23 Final 2 winners

Vote yourself for the Longevity Bracket: https://www.optispan.life/longevity-bracket

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

Professor Michael Crawford is a renowned scientist and Director of the Institue of Brain Chemistry and Human Nutrition in Imperial College London. He’s known for his research demonstrating the essential role of omega-3s specifically DHA in brain development and human evolution. He’s been pioneering this research since the 70s and he’s 95 years old himself.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

01:00 How Dr Crawford started researching DHA and omega-3s

04:00 Relationship between DHA and brain structure across species

07:00 How DHA drove the evolution of the human brain

12:20 Did humans evolve because of hunting land animals or consuming seafood

16:10 How a waxy fatty layer covering human babies makes us so different from other land animals

19:50 Bon Charge sponsorship

20:50 How the early stages of human brain evolution might have looked like

24:20 Why did DHA allow our brains to develop so well

27:20 Declining IQ and brain health conditions

31:00 Behavioral disorders and DHA

34:05 Iodine and other nutrients for brain development

36:55 Dr Crawford’s amazing cognition at the age of 95

39:20 How much DHA would people need per day

41:40 Is fish high in heavy metals

46:40 Omega-3s from meat

50:20 Plant-based omega-3s

51:20 Bottleneck for cranial capacity for land animals

54:55 Supplementing vs eating seafood

56:20 Omega-6 vs omega-3s

57:30 What needs to be done for fixing nutrition

01:03:30 Can you catch up with lost brain development

01:06:00 Are omega-3s easily oxidized

01:07:35 Advice for young researchers

01:10:05 Dr Crawford’s book

My 2026 longevity routine: https://youtu.be/OceysodInIo

100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Dr. Benjamin Blue is the Chief Executive Officer of Ora Biomedical, where he leads the company’s mission to develop therapies that target the biology of aging to prevent and treat disease. Dr. Blue holds a Ph.D. in Molecular Medicine and Mechanism of Disease (M3D) from the University of Washington School of Medicine and a B.S. in Biochemistry from the University of Oregon.

Timestamps:

00:00 Intro

00:35 The Million Molecule Challenge to find the enxt longevity molecule

05:15 How many molecules has Ora Biomedical tested

06:45 Most remarkable results in life extension so far

10:45 The process of finding life extension molecules

16:05 What’s the maximum life extension seen

17:15 Join our online community

18:15 Common supplements seen to extend lifespan

21:55 Disappointing molecules for life extension

26:50 Aspects of health and longevity

30:45 Investigating radiation in space and aging

34:35 Likelihood of finding a molecule that extends lifespan by 200-300%

41:05 How does it translate to humans

48:25 Peptides effect on lifespan

52:05 Bottleneck in the longevity science

56:25 What compounds has Ben started taking himself

Dr Ben Blue Twitter: https://x.com/benblueAK

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

My 2026 longevity routine: https://youtu.be/OceysodInIoStart rewinding your biological clock: https://www.siimland.co/course