The Joe Cohen Show

Chronologically, you get 1 year older every year. But how old are you getting biologically?

In order to optimize longevity, you need to understand biological aging.

With all the different longevity and biological aging tests, it can be difficult to understand where to start.

Fortunately, we got Ryan Smith from Tru Diagnostic on todays episode to guide you on all things longevity and biological aging.

In this episode, Ryan highlights the different biological aging tests and which one is the most accurate.

He also gives helpful tips on how to reduce your pace of aging, and how that’s important for your overall lifespan.

Ryan Smith is founder of TruDiagnostic, which has created the largest private epigenetic database in the world with over 25,000 patients tested. From this dataset, they have created many new algorithms to interpret methylation data including algorithms to predict inflammatory markers, disease diagnosis, telomere length, aging pace, immune cell subsets, cellular replication, and more.

- Visit trudiagnostic.com

- Check out SelfDecode

- Join Joe’s online community

Timestamps:

(0:00) - Intro

(1:48) - Where does epigenetics fall into aging biomarkers?

(21:52) - Different responses in anti-aging protocols

(39:44) - epigenetic test vs lab tests

(48:42) - How to use biological age tests to improve health

(55:09) - pace of aging

(1:05:15) - Immune system age

(1:09:11) - How to reduce the pace of aging

(1:26:39) - How many supplements does Ryan take per day?

(1:35:42) - Metformin and rapamycin on aging

Is the ApoE gene solely a predictor of cognitive decline, or is it just one piece of a larger, more intricate puzzle?

In today's episode, we focus on the ApoE gene, a genetic player that’s most notoriously linked to Alzheimer's Disease.

Julia dives deep into the three major variants called E2, E3, and E4, discussing how they change the shape of the ApoE protein and impact how well it functions.

she  also opens up the curtain on other health issues that can be caused by the ApoE gene —impacting your cardiovascular health, your body's inflammatory responses, and even your longevity.

Join us as we explore the layers of ApoE, debunk misconceptions, and discuss how understanding this gene could be a key step in taking control of your cognitive and overall health. Whether you're a genetic novice or a seasoned veteran in the world of SNPs, this episode will provide a comprehensive, yet easy-to-understand look into the multi-faceted role of the ApoE gene.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Why are there so many different versions of the same supplement? Is it all just a marketing ploy, or do they all have different effects on your health?

In this episode, Emiel Bakker from Nootropics Depot comes on to dive into the complex world of dietary supplements, where not all products are created equal.

He gives us an inside look at the science behind developing a supplement, from deciding on an extraction method to choosing between a fruiting body vs. mycelium.

We uncover the nuanced factors that influence the efficacy and effects of some popular supplements, including:

And more!

Emiel Bakker is the product specialist at Nootropics Depot and Natrium Health, a company specializing in creating the best nootropic powders and capsules online. They offer pure nootropics and dietary supplements at the best prices.

- Visit Nootropics Depot website

- Find Emiel @prettychill_nd

- Check out SelfDecode

- Join Joe’s online community

Timestamps:

(0:00) - Intro

(2:07) - Different variations of the same supplement

(17:21) - Erinacine A and Lion’s Mane

(19:57) - Pregnenalone

(26:51) - Tetrahydromagnolol and Magnolia Bark

(40:36) - How SelfDecode helps you understand supplements

(42:29) - Bacopa for Serotonin

(57:58) - Different effects of Maca

(1:09:28) - Oroxylin A and effects on cognition

(1:13:53) - Effects of Saffron

(1:20:28) - How many supplements do you take a day?

(1:22:33) - Ubiquinol vs CoQ10

(1:24:29) - Licorice Extract

How can you measure autophagy for certain? And what are the key stages to an effective fasting regimen?

Returning guest, Dr. Joseph Antoun from L-Nutra, the visionary company spearheading the fast-mimicking diet revolution, is here to answer these questions.

In this enlightening conversation, we delve into:

And so much more!

Dr. Joseph Antoun is the CEO & Chairman of the Board of L-Nutra and a Member of the Forbes Business Development Council. He is also the former CEO of Health Systems Reform, an organization committed to optimizing public health.

- Get 20% OFF All Products at https://l-nutra.com/ by using Code “JOE20”

- Check out SelfDecode

- Join Joe’s online community

Timestamps:

(0:00) - Intro

(2:58) - Fasting mimicking diet best benefits

(5:12) - Discussing autophagy

(23:58) - Recommended number of times to fast

(26:10) - Fasting for diabetes

(28:27) - How to properly do intermittent fasting

(42:00) - Nutrient sensing

(47:43) - Theories on stem cells

(50:02) - Clinical trials supporting fasting mimicking

(54:57) - Biological aging tests

(1:07:56) - Does Joseph take supplements?

Welcome back to SNPits, a short form series helping you decode your DNA, one gene at a time. 

In this episode, we delve into the fascinating world of the COMT gene, commonly dubbed the "Warrior/Worrier" gene.

We unpack the science behind this gene's influence on stress regulation, emotional resilience, and even cognitive function. 

Is the "Warrior/Worrier" label an oversimplification, or does it offer a genuine glimpse into our genetic predisposition?

Whether you're well-versed in genetics or just taking your first steps into this fascinating realm, today's episode promises to be an intriguing exploration of the role genes play in shaping our reactions to life's challenges.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Links:

The warrior variant and its effects on stress and working memory [R, R, R, R]

The worrier variant and its effects on stress and emotional resilience [R, R, R, R, R].

Join us as we dive deep into the world of genomics, nutrition, and precision health with Dr. Greg Nacarelli, a leading expert in naturopathic medicine and genetics. 

Dr. Nacarelli delves into the intricate interplay of genetics, environment, and lifestyle on our health, explaining why personalizing health care is the future.

Greg touches on the value of understanding individual genetic profiles and how this can be utilized for personalized nutrition and health coaching. 

With extensive academic qualifications and years of experience working with SelfDecode, Greg brings a unique blend of expertise to the table. 

Whether you're a health professional or just a health enthusiast, this episode offers invaluable insights into the cutting-edge world of genomics and how it's shaping the future of personalized medicine. 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Timestamps:

(0:00) - Intro

(2:53) - Practitioners Course

(8:09) - How A Health Practitioner Uses SelfDecode

(16:55) - Using the recommendations feature

(25:44) - Continuing the health practitioners use of SelfDecode

Dive deep into the intricate world of gut health with the pioneer himself, Dr. Steven Gundry. 

Once dismissed as pseudoscience, the concept of 'leaky gut' has become a cornerstone of modern health understanding, and no one knows this better than Dr. Gundry. 

In this enlightening episode, we unravel the real science behind leaky gut, the dangers of food sensitivities, and the profound effects of glyphosate on our system. 

Beyond just understanding, Dr. Gundry shares actionable insights on optimizing your gut health to transform your overall well-being. 

Whether you're a long-time health enthusiast or just beginning your journey, this episode offers a treasure trove of knowledge.

Timestamps:

(0:00) - Introduction

(3:30) - Dr. Gundry's current ideal diet

(9:12) - Autoimmune Disease Reversal & Leaky Gut 

(17:08) - IgG Antibodies

(27:29) - Other markers attributed to leaky gut

(34:14) - Glyphosate and linoleic acid

(48:20) - Top things to counteract food sensitivities

(54:23) - LPa, ApoB and LDL Cholesterol

(1:02:09) - Thoughts on diet studies with beans and whole grains

(1:05:44) - Protein Restriction & Intermittent Fasting

(1:11:08) - Fibers and gas

Welcome to SNPits, a new, short-form podcast series that takes you on a deep dive into specific genes, unraveling the science behind them and their impact on health. 

In this episode, we tackle the MTHFR gene and its rise to fame.

We explore how 'typos' in our genes, known as SNPs, influence our health, and dive into the debate surrounding one of the most studied genes in the world. 

Is the MTHFR gene truly a culprit in conditions like heart disease and chronic fatigue, or is it a scapegoat? 

Join us as we decode the science, bust some myths, and take a closer look at how our genes really affect our health. Whether you're a genetics guru or new to the subject, this episode offers an insightful and entertaining look at the complexity of our genetic code. 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Links:

Some studies found a 35-70% reduction in enzyme activity [R], and links between MTHFR variants, higher homocysteine, and:

Some studies found no evidence for these links. Some even found the opposite results. In one study, MTHFR variants were linked to a lower risk of death from heart disease [R, R, R, R, R]

To celebrate the richness of this season, we've compiled the most powerful insights and the unforgettable moments into a special "Best of Season 3" episode. From experts breaking down complex health subjects to invaluable pieces of advice on achieving your healthiest self, this episode is your ultimate guide to the knowledge treasure of Season 3.

Is anxiety truly genetic? How do our genes and environment shape our response to stress? Are we all experiencing the world differently based on our unique biochemical make-up? 

In this episode, Joe and Dr. Greg (SelfDecode Health Expert) dive deep into the realm of anxiety, answering questions from the SelfDecode community and unmasking the role our brain's biochemistry plays in the expression of anxiety.

Joe and Greg discuss the role of mental health in overall wellness and highlight specific genes that you can look at to potentially help you get rid of anxiety.

They then focus on the nutrients most commonly depleted under chronic stress and their links to anxiety, and break down some herbal supplements that work wonders in balancing our brain's neurotransmitters. 

From the influence of specific genes like COMT and MTHFR, to the vital role of minerals like magnesium, zinc, and vitamin B6, this episode is a deep dive into the science of anxiety!

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠