Methylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In our last episode, we introduced the topic of methylation and the basics of the biochemical reaction.  However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance.

Today, we dive a bit deeper into the biochemistry and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Genova’s Methylation Pathway Handout to follow along.

“Should we do case studies on the podcast? Email your opinion to [email protected]!” – Patti and Michael

 

Today on The Lab Report:

• 2:50 Quick review of the methylation cycle
• 4:45 The important relationship between choline and betaine
• 7:05 Logical Speculation: Why is the betaine: choline ratio associated with disease risk?
• 9:35 Dimethylglycine (DMG)
• 11:15 Sarcosine and the ‘SAM disposal chute’
• 14:20 Glycine: What does it do?
• 16:55 Transsulfuration and glutathione
• 21:00 The multi-omics of the methylation panel
• 22:25 Question of the Day:  What is the stability of measuring SAM and SAH?

 

Additional Resources:

Genova's Methylation Panel

Dr. Michael Chapman's Methylation Webinar

 

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and show not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

 

 

 

 

 

See omnystudio.com/listener for privacy information.