Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.

Today’s episode is a discussion of the cytochrome P450 enzyme CYP1B1. This enzyme is important in hormone detoxification. Genetic variants (single nucleotide polymorphisms or SNPs) in CYP1B1 might predispose a patient for risk regarding many hormonally mediated diseases, though this is not always the case. Listen to find out more about the enzyme pathways used in estrogen detoxification, what to look for when deciding if a genetic variant in CYP1B1 is expressed, and learn what you can do to about it.

“Some SNPs result in an enzyme that works faster (upregulation). Some SNPs result in an enzyme that works slower (downregulation).” – Michael Chapman, ND

Today on The Lab Report:

• 2:30 Cytochrome P450 enzymes and CYP1B1
• 2:55 Review of general Phase I and Phase II detoxification
• 7:00 Basics of estrogen detoxification pathways and where CYP1B1 works
• 9:00 What does a SNP in CYB1B1 do?
• 11:45 What profiles and biomarkers are helpful to assess expression of a CYPB1B1 SNP?
• 17:00 How do we support patients with a CYP1B1 SNP?
• 21:05 Question of the day:
  • “What is the difference between FMV and 24hour Complete Hormones?”

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