The Autoimmune RESET

The Mystery of MCAS: Why Your Body is Always on High Alert


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In this episode, we’re uncovering a misunderstood and often hidden contributor to chronic symptoms in autoimmunity: mast cell activation syndrome (MCAS) — and why your body may be reacting to food, supplements, and even stress like it’s under constant attack.

Join VJ Hamilton, registered nutritionist and autoimmune health specialist, as we dive into the science behind MCAS, how it overlaps with autoimmune conditions like Hashimoto’s, lupus, and rheumatoid arthritis, and what you can do to calm your immune system from the inside out.

You’ll discover:

  • What MCAS is and how it mimics or overlaps with other autoimmune and chronic illnesses
  • Why some people produce too much histamine and can’t clear it effectively — the “double whammy” of MCAS and histamine intolerance
  • Root causes and triggers of MCAS, including mould exposure, infections, oestrogen dominance, and nervous system dysregulation
  • How trauma, chronic stress, and vagus nerve dysfunction keep your immune system on high alert
  • Nervous system tools that help “retrain” mast cells — including somatic therapy, vagus nerve practices, and Nurosym
  • The role of supplements like quercetin, vitamin C, luteolin, DAO enzyme, and magnesium glycinate in calming mast cells
  • When to seek help and how to navigate MCAS testing and therapeutic trials with the right support

Plus, I share practical, evidence-informed strategies to reduce triggers, nourish your nervous system, and take a systems-based approach to MCAS — even without a formal diagnosis.

Resources Mentioned in the Episode

🧠 Explore Nurosym – A non-invasive vagus nerve stimulation device to support nervous system balance and reduce immune overactivation. Use code VJ5 for 5% off at checkout.

📄 Download: Low histamine diet– www.histaminintoleranz.ch/downloads/SIGHI-Leaflet_HistamineEliminationDiet.pdf

🛒 Shop BodyBio – Trusted, practitioner-quality supplements for immune and cellular health. Use code VJ15 for 15% off at bodybio.

Perfect for you if:

  • You have an autoimmune condition and still struggle with unexplained flares, fatigue, or food reactivity
  • You’ve been told your labs are normal, but you know something deeper is going on
  • You want a root-cause approach to immune dysregulation, not just symptom suppression
  • You’re curious about the link between trauma, stress, and chronic inflammation

The information shared in this episode is for educational purposes only and is not intended to replace medical advice. Always consult your healthcare provider before making changes to your medications, supplements, or treatment plan — especially if you have a diagnosed autoimmune condition.

Some resources or products mentioned in this episode may include affiliate links. This means I may earn a small commission if you choose to purchase through them — at no additional cost to you. I only recommend tools and products I believe in and use with clients.

Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

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The Autoimmune RESETBy VJ Hamilton

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