I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.  

The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications. 
 
If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications you need.
 
Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. 

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Timestamps 
00:00 Introduction 
02:30 Methylene Blue's Role in Neurotransmitter Regulation 
07:54 Mitochondrial Health and Methylene Blue 
17:02 Methylene Blue and Modern Health Challenges 
25:27 Methylene Blue in Hypobaric and Hyperbaric Environments 
29:47 Understanding Hyperbaric Oxygen Therapy 
32:27 Methylene Blue: A Mitochondrial Rescue 
36:52 Bioavailability of Methylene Blue 
42:17 Dosing and Applications of Methylene Blue 
47:46 Combining Methylene Blue with Other Treatments 
54:02 Conclusion and Further Resources

The Neuro Athletics Newsletter
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The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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Alzheimer’s doesn’t just “happen” later in life—it’s a slow, silent process that can begin decades before symptoms appear. In this solo episode, we challenge the myth that Alzheimer’s is purely genetic, and break down what the science really says about your risk.

I explore the role of the APOE4 gene, how it interacts with lifestyle and metabolic health, and why women—especially during and after menopause—may face a unique vulnerability. Most importantly, I introduce three cutting-edge blood tests that can detect the earliest signs of Alzheimer’s, long before memory loss sets in.

We’ll also talk prevention: from blood sugar and insulin resistance to inflammation, hormone balance, and brain energy metabolism—everything you can start doing right now to safeguard your cognitive future.

This is more than a conversation about Alzheimer’s—it’s a roadmap for taking control of your brain health.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuro

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Timestamps:
00:00 Top Alzheimer’s Myth: Genetics Don’t Seal Your Fate
01:43 APOE4 Gene Explained: Risk Factors vs. Reality
04:00 Alzheimer’s Risk Isn’t Just in Your DNA
10:50 Top 3 Alzheimer’s Biomarkers You Can Test for Today
14:47 APOE4 Prevention Plan: Lifestyle Changes That Protect Your Brain 

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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Testosterone is often misunderstood as a male-exclusive hormone, but did you know that women have four times more testosterone than estrogen? In this episode, I sit down with leading urologist and sexual health expert Dr Rena Malik to uncover the critical role testosterone plays in cognitive function, energy levels, muscle strength, and overall well-being in women.

We explore:
• The misunderstood role of testosterone in female physiology
• Why testosterone deficiency is more common than you think – and how to identify it
• The impact of stress, sleep, and modern lifestyles on hormonal balance
• The link between testosterone and brain fog, motivation, and libido
• Why resistance training is essential for hormonal health
• Medical vs. natural interventions – from supplementation to lifestyle strategies

With emerging research highlighting the intricate relationship between hormones and long-term cognitive and metabolic health, this conversation is a must-listen for anyone looking to optimise longevity, vitality, and performance.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuro

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Timestamps:

00:00 Introduction
01:58 Symptoms and Effects of Low Testosterone
03:06 Testosterone's Role in Female Health
06:58 Factors Affecting Testosterone Levels
10:57 Impact of Lifestyle on Hormone Levels
15:00 Seasonal and Circadian Influences
20:41 Perimenopause and Hormonal Changes
24:18 The Role of Testosterone in Mood and Motivation
31:53 DHEA Supplementation and Hormonal Balance
40:01 The Importance of Strength Training and Sleep
44:31 Nutritional Tips for Hormonal Health

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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In today's episode I am kicking off a 10-part series, "Women's Guide to Alzheimer's Disease," focusing on understanding the complexities of the brain. Delve into the basics of neurons, synaptic connections, and the essential role of vascular health in cognitive function. 

Discover how lifestyle factors contribute to Alzheimer's and the critical window for intervention. 

Explore key elements like mitochondrial function and the APOE4 gene's impact. With insights into brain health and disease prevention, this episode lays the groundwork for optimizing cognitive performance and demystifying Alzheimer's.

Sponsors

ZocDoc: https://www.zocdoc.com/neuro
Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro

Timestamps
0:00 Understanding the Brain's Role in Alzheimer's Disease
3:55 Momentous Supplements: Purity, Potency, and Safety Guaranteed
5:15 Streamlining Doctor Appointments with Zocdoc
6:38 The Brain's Vascular Health and Its Link to Alzheimer's
9:27 Understanding Alzheimer's Disease and Brain Health Interventions

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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Dr. Inigo San Milan: Leading Expert in Metabolism, Exercise Physiology, and Cancer Research

Dr. Inigo San Milan is a globally recognized expert in metabolic health, exercise science, Zone 2 training, mitochondrial function, and cancer metabolism.

His groundbreaking research has transformed the understanding of lactate, highlighting its role not just in athletic performance but also in metabolic diseases, cancer progression, and longevity. As a strong advocate of Zone 2 training, Dr. San Milan has demonstrated how it boosts mitochondrial efficiency, improves endurance, enhances fat metabolism, and supports overall healthspan.

His pioneering approach explores cancer treatment through metabolic optimization, shifting the focus from traditional gene-targeted therapies to cellular energy balance and metabolic interventions. Dr. San Milan’s work provides a science-backed strategy for disease prevention, peak performance, and longevity through targeted metabolic conditioning.

Sponsors:

ZocDoc: https://www.zocdoc.com/neuro
Hone Health Hormone Testing: https://honehealth.com/
Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro

Timestamps

0:00 Revolutionizing Cancer Treatment Through Metabolism Optimization
5:00 Exploring Skeletal Muscle's Role in Cancer Prevention and Treatment
13:14 Lactate's Role in Cancer and Metabolic Disorders
18:21 Nanoparticles in Cancer Treatment and Funding Challenges
22:21 Understanding Zone 2 Training and Its Potential Health Benefits
25:52 Understanding Exercise Zones and Metabolic Fuel Sources
31:39 The Benefits of Zone Two Training for Longevity and Health
40:50 Rethinking Exercise Guidelines for Optimal Health
43:11 Exploring the Impact of Zone 2 Exercise on Cancer
50:41 Optimizing Exercise for Cancer Prevention and Longevity

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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Professor Thomas Seyfried joins the conversation to challenge the conventional view of cancer as a genetic disease, presenting it instead as a metabolic disorder influenced by lifestyle factors.

With over 30 years of research, Seyfried argues that current cancer treatments may exacerbate the disease. He discusses the role of glucose and glutamine in cancer metabolism and emphasizes the potential of metabolic therapy, including ketogenic diets, for prevention and management. Explore the compelling intersection of biochemistry, lifestyle, and cancer with Seyfried's groundbreaking insights.

Sponsors:

ZocDoc: https://www.zocdoc.com/neuro
Hone Health Hormone Testing: https://honehealth.com/
Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro

Timestamp 

0:00 Challenging Cancer's Genetic Theory with Metabolic Insights
4:54 Cancer as a Metabolic Disorder Not a Genetic Disease
13:05 Challenging the Genetic Theory of Cancer Amidst Confirmation Bias
15:27 Booking Doctor Appointments Easily with ZocDoc
16:27 Mitochondria's Role in Cancer Cell Proliferation and Fermentation
21:08 Mitochondrial Dysfunction and Its Role in Cancer Development
31:23 Cancer Cells' Fermentation and Mitochondrial Dysfunction
37:33 Metabolic Therapy as a Non-Toxic Cancer Treatment Alternative
46:39 Exploring Diets and Metabolic Pressure on Cancer Cells
49:36 Exercise and Diet in Cancer Treatment Targeting Glutamine
50:50 Ketogenic Lifestyle's Impact on Cancer and Chronic Diseases
52:40 Targeting Glucose and Glutamine to Combat Pancreatic Cancer
54:36 Impact of Modern Lifestyle on Health and Chronic Diseases
58:26 Metabolic Therapy as a Disruptive Cancer Prevention and Treatment

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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