What if cancer isn't primarily a genetic disease — but a metabolic one?

In this groundbreaking conversation, Professor Thomas N. Seyfried, PhD (Boston College), author of Cancer as a Metabolic Disease, joins Ralph W. Moss, PhD and Ben Moss to discuss the Mitochondrial and Metabolic Theory of Cancer — and why it challenges decades of conventional thinking.

Dr. Seyfried explains how cancer cells depend on glucose and glutamine as their dual fuel supply — and how cutting off both pathways may be the key to shutting cancer down. He details the role of the Glucose Ketone Index (GKI), nutritional ketosis, and new interest in anti-parasitic drugs like fenbendazole and mebendazole, which appear to target cancer's energy metabolism.

This episode explores:

• Why the somatic mutation theory no longer explains cancer's true origin
• How mitochondrial dysfunction drives tumor growth
• The critical role of glucose and glutamine fermentation in sustaining cancer cells
• Why targeting both fuels together is essential for effective therapy
• Emerging research on fenbendazole, mebendazole, and DON as tools in metabolic therapy
• The potential of a paradigm shift in oncology — from genes to metabolism

Resources:

This Podcast contains many scientific terms. To assist our readers in understanding them, we have created this glossary.

The article with links, resources and full transcript can be found here:

https://themossreport.com/s5-e13-prof-thomas-seyfried-mitochondrial-metabolic-theory/

Direct link to The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer

https://link.springer.com/content/pdf/10.1007/s10863-025-10059-w.pdf

In the Journal

https://link.springer.com/article/10.1007/s10863-025-10059-w

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis

Christos Chinopoulos & Thomas N. Seyfried Paper

https://www.tandfonline.com/doi/epdf/10.1177/1759091418818261?needAccess=true (PDF)

https://www.tandfonline.com/doi/full/10.1177/1759091418818261

Christos Chinopoulos

https://semmelweis.hu/english/2019/09/my-university-dr-christos-chinopoulos-and-the-rppa-facility/

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

https://pubmed.ncbi.nlm.nih.gov/31149644

Glucose Ketone Index Calculator Post

https://pmc.ncbi.nlm.nih.gov/articles/PMC4367849

Spreadsheet with calculator

https://pmc.ncbi.nlm.nih.gov/articles/instance/4367849/bin/12986_2015_9_MOESM1_ESM.xlsx

Sam Apple - Ravenous

https://amzn.to/4nr6YMP

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