协和八啦吧在创立初期，就是想做一个医学生的咖啡屋，大家坐在一起聊聊天。当代人体内流淌着的一定是咖啡，早上一杯，消消肿，下午一杯，退去午后的困倦，晚上一杯，赶ddl。这一期，我们认真搜索了Pubmed、Scopus、Cochrane，来仔细讲一讲关于咖啡的正确饮用方式。本期全程干货，不过还是一句话，咖啡虽好，适量饮用。

本期节目，你将听到：

• 2:38 对咖啡的偏见
• 6:35 我是怎么喜欢上喝咖啡
• 16:00 我为什么会困呢
• 20:09 咖啡或降低胶质瘤发生风险
• 22:17 改善2型糖尿病风险
• 22:45 咖啡可以帮助减脂嘛？
• 26:40 咖啡对胃是好是坏?
• 33:07 一天6杯咖啡增加痴呆风险
• 35:26 不同咖啡的咖啡因含量
• 39:32 咖啡让人缺钙，那咖啡＋奶呢?
• 44:53 孕妇可以喝咖啡吗
• 50:34 速溶、挂耳、胶囊、自磨豆

【不同咖啡的咖啡因】

【参考文献】

[1] Lucas M, O'Reilly EJ, Pan A, Mirzaei F, Willett WC, Okereke OI, Ascherio A. Coffee, caffeine, and risk of completed suicide: results from three prospective cohorts of American adults. World J Biol Psychiatry. 2014 Jul;15(5):377-86. doi: 10.3109/15622975.2013.795243. Epub 2013 Jul 2. PMID: 23819683;

[2] Wang L, Shen X, Wu Y, Zhang D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. Aust N Z J Psychiatry. 2016 Mar;50(3):228-42. doi: 10.1177/0004867415603131. Epub 2015 Sep 2. PMID: 26339067.

[3] Liu QP, Wu YF, Cheng HY, Xia T, Ding H, Wang H, Wang ZM, Xu Y. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition. 2016 Jun;32(6):628-36. doi: 10.1016/j.nut.2015.11.015. Epub 2015 Dec 31. PMID: 26944757.

[4] Wadhawan M, Anand AC. Coffee and Liver Disease. J Clin Exp Hepatol. 2016 Mar;6(1):40-6. doi: 10.1016/j.jceh.2016.02.003. Epub 2016 Feb 27. PMID: 27194895; PMCID: PMC4862107.

[5] Heath R D, Brahmbhatt M, Tahan A C, et al. Coffee: The magical bean for liver diseases[J]. World journal of hepatology, 2017, 9(15): 689.

[6] Southward K, Rutherfurd-Markwick KJ, Ali A. The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis. Sports Med. 2018 Aug;48(8):1913-1928. doi: 10.1007/s40279-018-0939-8. Erratum in: Sports Med. 2018 Aug 9;: PMID: 29876876.

[8] Torres-Collado L, Compañ-Gabucio LM, González-Palacios S, Notario-Barandiaran L, Oncina-Cánovas A, Vioque J, García-de la Hera M. Coffee Consumption and All-Cause, Cardiovascular, and Cancer Mortality in an Adult Mediterranean Population. Nutrients. 2021 Apr 9;13(4):1241. doi: 10.3390/nu13041241. PM

[9] Salazar-Martinez E, Willett WC, Ascherio A, et al. Coffee consumption and risk for type 2 diabetes mellitus.Ann Intern Med. 2004;140(1):1-8. doi:10.7326/0003-4819-140-1-200401060-00005

[10] Chen L-W, Wu Y, Neelakantan N, Chong MF-F, Pan A, van Dam RM. Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. BMC Med 2014;12:174-174.

[11] Chen L-W, Wu Y, Neelakantan N, Chong MF-F, Pan A, van Dam RM. Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies. Public Health Nutr 2016;19:1233-1244.

[12] Gaskins AJ, Rich-Edwards JW, Williams PL, Toth TL, Missmer SA, Chavarro JE. Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur J Nutr 2018;57:107-117.

[13] Alperet DJ, Rebello SA, Khoo EY-H, et al. The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: a randomized placebo-controlled trial. Am J Clin Nutr 2020;111:448-458.

[14] Ohnaka K, Ikeda M, Maki T, et al. Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. J Nutr Metab 2012;2012:207426-207426.

[15] Ogawa T, Sawada N, Iwasaki M, et al. Coffee and green tea consumption in relation to brain tumor risk in a Japanese population. Int J Cancer. 2016;139(12):2714-2721. doi:10.1002/ijc.30405

【本期背景音乐】开头《Numb Little Bug》Em Beihold；结尾《Celle de mes 20 ans》Mélanie Pain