The Obesity Guide with Matthea Rentea MD

Why "Stopped Working" Is the Wrong Way to Think About GLP-1 Plateaus


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Ever heard that GLP-1 medications "stop working" after a certain point? It’s a common myth fueled by influencers, “coaches”, and even misinterpreted studies. But it’s not the truth.

These misleading claims can leave you feeling stuck or defeated, as if your progress has hit a hard limit. Plus, that mindset can make you overlook the real results you’ve achieved and the many strategies still available to support your health.

In this episode, I set the record straight. You’ll learn why plateaus are normal, how to see them as maintenance rather than failure, and what you can do alongside medication to keep moving forward. By the end, you’ll see why the phrase “the meds don’t work anymore” is not only misleading, but also holds you back from achieving more.

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Audio Stamps

00:30 – Why the claim that "GLP-1 medications stop working" is misleading and what's really happening.

02:05 – The truth about weight loss plateaus: why studies show maintenance phases and what this actually means for your progress.

02:43 – Why most GLP-1 studies don't use a multifaceted approach to weight management and how this limits the data.

04:50 – Why any weight loss is significant, even when it feels small.

05:17 – How to know your medication is still working: the one-week challenge that proves these drugs are doing more than you realize.

05:54 - Warning about online health content that's really just a sales pitch for supplements and products.


All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

✨ Season 2 of Behind the Curtain is officially live! ✨ You can join the season on its own or take it a step further by opting into the live 21-Day Challenge with Dr. Rentea, running December 1–21—the perfect way to finish the year strong and head into the holidays with momentum.👉 JOIN HERE — spots are limited for the live challenge!

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The Obesity Guide with Matthea Rentea MDBy Matthea Rentea MD

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