The Obesity Guide with Matthea Rentea MD

Your Friday Five: Top Tips for Month One on Zepbound


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This week’s Your Friday Five is a little different — I’m answering a fan mail question about what to expect during the first month on Zepbound (tirzepatide). If you’re just starting your GLP-1 journey, this episode is packed with quick, practical advice.

In this episode, I cover:

  1. Why hydration is non-negotiable — and what to look for beyond just ounces.
  2. Protein goals and how to get your grams in even when your appetite drops.
  3. The role of fiber and how to ease your way in.
  4. Why experimenting with food textures, combinations, and timing is key early on.
  5. What to avoid to prevent nausea and other common side effects.

Bonus insight: The first 2–3 months are a learning curve. Be patient with your body as it adjusts to the medication.

Want a step-by-step, deeper dive? Check out my Mini Course: “Top 5 Mistakes People Make On a GLP-1” — complete with quick videos, live Q&As, bonus resources, and a supportive community. Get access HERE.

And if you send in a fan mail question, make sure to include your email so we can follow up with more resources just for you.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

If you want to go deeper into the science of fat loss, muscle preservation, and what your body composition numbers actually mean, check out my course Body Composition Decoded, where I break it all down in a clear, practical way.

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The Obesity Guide with Matthea Rentea MDBy Matthea Rentea MD

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