In this thought-provoking episode of Metabolic Matters, Dr. Nasha Winters sits down with Dr. Robert Lustig, a pioneer in neuroendocrinology and metabolic research, to challenge the most deeply held assumptions about health, nutrition, and chronic disease.

Dr. Lustig shares the personal journey and clinical breakthroughs that led him to uncover how our modern food system, misinformed science, and biochemical dysfunction have hijacked not just our bodies, but our brains. From leptin resistance and childhood obesity to mitochondrial failure and insulin overload, this conversation is packed with powerful insights for anyone seeking to understand the true roots of metabolic dysfunction.

• Why obesity is not a result of gluttony or sloth — but a hormonal and neurological response

• How mitochondrial dysfunction underlies chronic disease, from cancer to diabetes

• The critical difference between food science, nutrition, and metabolic health

• What happens when insulin levels rise — and how to bring them down

• The story behind Freeing the Hostage Brain, Dr. Lustig’s upcoming book
  Metabolic health, mitochondria, insulin resistance, fructose, leptin, obesity, chronic disease, Dr. Robert Lustig, ultra-processed food, root cause medicine, neuroendocrinology, nutrition, energy balance, brain health.

Dr. Robert Lustig is Professor Emeritus of Pediatrics in the Division of Endocrinology at the University of California, San Francisco (UCSF). A globally recognized expert in neuroendocrinology and nutrition, he has spent decades researching childhood obesity, insulin resistance, and the food industry’s role in modern disease. His books include Fat Chance, Sugar: The Bitter Truth, Metabolical, and the upcoming Freeing the Hostage Brain.

• Dr. Lustig’s books: Metabolical, Sugar: The Bitter Truth, Fat Chance

• Upcoming book: Freeing the Hostage Brain (Fall 2025)

• How Sugar & Processed Foods Impact your Health: https://www.youtube.com/watch?v=n28W4AmvMDE

Connect with Dr. Lustig: 

🔗profiles.ucsf.edu/robert.lustig

🔗https://bsky.app/profile/robertlustigmd.bsky.social

Website: www.robertlustig.com

FB: https://www.facebook.com/DrRobertLustig/

Insta: https://www.instagram.com/robertlustigmd/

YT: https://www.youtube.com/channel/UC0Rnz8dv1-25An6Q8DK5uLg

X: https://x.com/RobertLustigMD

LI: https://www.linkedin.com/in/robert-lustig-8904245/

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