January 27, 2025

134. I Want to Stop my GLP1 Medication

30 minutes

In this episode, we're tackling a question I’ve been hearing a lot: What happens if you want to stop your GLP-1 medication (like Ozempic, Wegovy, Mounjaro, Zepbound, or Saxenda)? Whether you’re making this decision voluntarily or because circumstances force it, I’ll walk you through evidence-based strategies to minimize weight regain and ensure the best outcomes.

Here’s what I’ll cover today:

What happens when you stop GLP-1 medications?

GLP-1s are not just weight loss tools; they treat a chronic disease—obesity.

Weight regain after stopping is common and tied to metabolic and hormonal adaptations.

What research tells us about this transition:

The STEP-1 Extension Trial showed patients regained about two-thirds of the weight they lost after stopping semaglutide, even with lifestyle interventions.

A Diabetes, Obesity and Metabolism study highlights that weight regain is a natural metabolic response, not a failure of willpower.

Why long-term GLP-1 use is often recommended:

Think of GLP-1s like treatment for other chronic diseases, such as diabetes or hypertension. For most people, ongoing therapy is necessary for sustained benefits.

Evidence-based strategies for transitioning off GLP-1s:

Gradual tapering: Slowly reduce your dose under medical supervision.

Focus on nutrition: Increase protein intake and monitor your eating habits closely.

Prioritize physical activity: Incorporate resistance training to preserve muscle and support your metabolism.

Use psychological tools: Employ CBT or other techniques to handle emotional eating and cravings.

Consider adjunct therapies: Discuss options like metformin with your doctor.

Key takeaway:
Transitioning off GLP-1s is not one-size-fits-all. It requires close collaboration with your healthcare provider, a strong emphasis on lifestyle habits, and ongoing psychological support. Whatever path you choose, remember this journey is about long-term health, not just weight loss.

🎧 If you’re looking for guidance on building resilience and consistency to create your healthiest lifestyle, whether you’re on or off GLP-1 medications, check out my coaching program, Best Weight, on my website: www.sashahighmd.com/bestweight.

References from today’s episode:

STEP-1 Extension Trial: Read more

SURMOUNT-4: Read more

Copenhagen study on tapering off GLP-1s: Learn more

...more

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By Sasha High

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