<a target="_blank" href="https://www.buzzsprout.com/twilio/text_messages/1535644/open_sms">Send us a text</a>Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. They discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more.*Not medical advice. <a rel="payment" href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter">Support the show</a>Affiliates: <ul> <li> <a href='https://download.seedoilscout.com/xhLZ?af_xp=custom&pid=affiliate&c=Nick%20Jikomes'>Seed Oil Scout</a>: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.</li> <li> <a href='https://santabarbaranutrients.com/products/ketocitra'>KetoCitra</a>—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)</li> <li> <a href='https://www.lumen.me/shop?fid=8731&discount=MINDMATTER'>Lumen device</a> to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off</li> <li> <a href='https://siphoxhealth.com/?sca_ref=5338127.lZ39LNbYg8'>SiPhox Health</a>—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.</li> </ul> For all the ways you can <a href='https://mindandmatter.substack.com/p/how-to-support-mind-and-matter'>support my efforts</a>

Send us a text Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. They discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more. *Not medical advice. Support the show Affiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

<a href="https://www.buzzsprout.com/twilio/text_messages/1535644/open_sms" rel="noopener noreferrer">Send us a text</a>Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. They discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant &amp; modulator of aging; the effects of diet &amp; caloric restriction on aging; the potential slowing and reversing aging, and more.*Not medical advice. <a href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter" rel="noopener noreferrer">Support the show</a>Affiliates: <ul> <li> <a href="https://download.seedoilscout.com/xhLZ?af_xp=custom&amp;pid=affiliate&amp;c=Nick%20Jikomes" rel="noopener noreferrer">Seed Oil Scout</a>: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.</li> <li> <a href="https://santabarbaranutrients.com/products/ketocitra" rel="noopener noreferrer">KetoCitra</a>—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)</li> <li> <a href="https://www.lumen.me/shop?fid=8731&amp;discount=MINDMATTER" rel="noopener noreferrer">Lumen device</a> to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off</li> <li> <a href="https://siphoxhealth.com/?sca_ref=5338127.lZ39LNbYg8" rel="noopener noreferrer">SiPhox Health</a>—Affordable at-home blood testing. Key health markers, visualized &amp; explained. Code TRIKOMES for a 20% discount.</li> </ul> For all the ways you can <a href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter" rel="noopener noreferrer">support my efforts</a>

Aging, Metabolism, Calorie Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | Joe Baur | 64

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists &amp; thinkers alive today about how your mind-body reacts to what you feed it. The weekly <a href="https://mindandmatter.substack.com/podcast?sort=top">M&amp;M podcast</a> features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&amp;M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body &amp; mind work by curating &amp; synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: <ul><li><a href="https://mindandmatter.substack.com/p/the-psychiatry-of-metabolism">Taking ownership of your health starts with taking ownership of your information diet</a>.</li><li>All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas &amp; preferred conclusions.</li><li>Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but <a href="https://mindandmatter.substack.com/p/what-is-psychological-dissociation-78d">pain is information.</a></li></ul> Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload &amp; historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: <ul><li>“Γνῶθι σεαυτόν” (Know thyself)</li><li>“Μηδὲν ἄγαν” (Nothing in excess)</li><li>“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)</li></ul>

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Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: Taking ownership of your health starts with taking ownership of your information diet.All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information. Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: “Γνῶθι σεαυτόν” (Know thyself)“Μηδὲν ἄγαν” (Nothing in excess)“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists &amp; thinkers alive today about how your mind-body reacts to what you feed it. The weekly <a href="https://mindandmatter.substack.com/podcast?sort=top" rel="noopener noreferrer">M&amp;M podcast</a> features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&amp;M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body &amp; mind work by curating &amp; synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: <ul><li><a href="https://mindandmatter.substack.com/p/the-psychiatry-of-metabolism" rel="noopener noreferrer">Taking ownership of your health starts with taking ownership of your information diet</a>.</li><li>All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas &amp; preferred conclusions.</li><li>Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but <a href="https://mindandmatter.substack.com/p/what-is-psychological-dissociation-78d" rel="noopener noreferrer">pain is information.</a></li></ul> Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload &amp; historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: <ul><li>“Γνῶθι σεαυτόν” (Know thyself)</li><li>“Μηδὲν ἄγαν” (Nothing in excess)</li><li>“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)</li></ul>

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Aging, Metabolism, Calorie Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | Joe Baur | 64

Aging, Metabolism, Calorie Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | Joe Baur | 64

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