The Dr. Hyman Show

Are Your Gut Issues, Headaches, Heart Palpitations, And Other Symptoms Due To Histamine Intolerance?​​


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This episode is brought to you by Rupa Health, Mitopure, and Cozy Earth


Histamine is a common term when discussing allergies, but there is really so much more to it. Histamine is both made by the body and found in food. It has a key function in digestion and also acts as a neurotransmitter. People who have more histamine in their bodies than they can break down may experience a variety of symptoms including hives, heart palpitations, migraines, fluid retention, runny nose, and more. Often, histamine intolerance can be traced back to gut dysbiosis and mast cell activation syndrome.


In today’s episode, I talk with Dr. Todd LePine, Dr. Leo Galland, and Lisa Dreher about how histamine plays a role in sleep, digestion, allergies, skin conditions, and so much more.


Dr. Todd LePine graduated from Dartmouth Medical School and is board certified in internal medicine, specializing in integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years.


Dr. Leo Galland is a board-certified internist, an international bestselling author, and one of the founders of Functional Medicine. Since the onset of the pandemic, he has devoted most of his time to research on Covid-19 and to the education of other health practitioners in understanding the biology of the disease. His latest publication, Long Covid: Prevention and Treatment, is available on his website.


Lisa Dreher is a registered dietitian who got her undergraduate nutrition degree at the Rochester Institute of Technology and completed a dietetic internship through Cornell University. Lisa first worked in the acute care hospital setting and became a clinical nutrition specialist working in pediatric gastroenterology at the University of Rochester Medical Center. At the same time, she pursued her master’s degree in nutrition and integrative health from the Maryland University of Integrative Health and started practicing integrative and functional nutrition in private practice before joining The UltraWellness Center in 2015.


This episode is brought to you by Rupa Health, Mitopure, and Cozy Earth.


Access more than 3,000 specialty lab tests with Rupa Health. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com today.


Support the growth of new, healthy mitochondria and get 10% off Mitopure. Head to timelinenutrition.com/drhyman and use code DRHYMAN10 at checkout.


Get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DRHYMAN.


Full-length episodes of these interviews can be found here:

Dr. Todd LePine (histamine intolerance)

Dr. Leo Galland

Dr. Todd LePine (ending migraines)

Lisa Dreher



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The Dr. Hyman ShowBy Dr. Mark Hyman

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