This episode covers: 

• Cocoa Extract Cuts Heart Deaths 

A massive COSMOS trial found that older adults taking high flavanol cocoa extract daily saw a 27 percent reduction in cardiovascular deaths along with drops in inflammation markers like HSCRP. Women showed unique anti inflammatory cytokine shifts, pointing to a broader longevity effect. Dave explains why cocoa extract is becoming a foundational nutrient for vascular health rather than a dessert ingredient. 

Source: https://www.sciencedaily.com/releases/2025/09/250926135957.htm 

• AI Stethoscope for Home Diagnostics 

Lapsi Health’s Keikku 2.0 just became the first FDA cleared AI powered digital stethoscope for both clinicians and home users. It records heart and lung sounds, analyzes them instantly, and flags early warning signs before symptoms appear. Dave breaks down why tools like this move you from reactive to predictive medicine and why they belong in every quantified self toolkit. 

Source: https://www.prnewswire.com/news-releases/lapsi-health-unveils-keikku-2-0-worlds-first-fda-cleared-digital-stethoscope-with-integrated-ai-scribe-302585083.html?utm_source=chatgpt.com 

• Beef Organ Supplements Surge 

Beef organ supplements have exploded more than 8,000 percent this year, driven largely by women reporting improvements in energy, hormones, mood, and skin. Liver, kidney, and heart deliver vitamin A, heme iron, B12, copper, and choline that modern diets often lack. Dave covers sourcing concerns, purity standards, and why this shift reflects a move from fear based nutrition to evolutionary nutrition. 

Source: https://www.verywellhealth.com/beef-organ-supplement-11710185?utm_source=chatgpt.com 

• Spirulina for Collagen and DNA Protection 

New research highlights spirulina’s ability to support collagen production, reduce oxidative stress, protect DNA, and improve glucose and lipid balance. It is becoming a staple of eco focused anti aging routines and is driving the viral green stacking trend with chlorella and chlorophyll. Dave explains why spirulina functions as a clean daily defense against oxidative stress. 

Source: https://www.news-medical.net/news/20250707/Is-Spirulina-the-Next-Anti-Aging-Superfood.aspx 

• Health Data Privacy Reform 

A new Senate bill aims to extend HIPAA level protections to wearables, genomic tools, glucose monitors, and wellness apps. The goal is to give users control over who sees their biometrics, how they are stored, and whether they can be sold. Dave outlines why this matters for anyone using Oura, Whoop, CGMs, or genetic testing and why your biology should belong to you and not the cloud. 

Source: https://natlawreview.com/article/federal-healthcare-update-november-7-2025 

All source links provided for easy reference to the original reporting and research above. 

This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: cocoa extract, flavanols, heart health, nitric oxide pathways, COSMOS trial, AI stethoscope, digital diagnostics, Keikku device, predictive health tech, beef organ supplements, women’s hormonal health, nutrient dense foods, ancestral nutrition, spirulina benefits, collagen support, oxidative stress defense, green stacking, chlorella pairing, DNA protection, wearable privacy laws, HIPAA reform, biometric data rights, longevity news, biohacking updates 

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• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

0:00 – Intro 

0:19 – Cocoa Extract & Heart Health 

1:52 – AI Digital Stethoscope 

3:01 – Beef Organ Supplements 

4:24 – Spirulina for Longevity 

5:42 – Substack Announcement 

6:53 – Health Data Privacy Reform 

8:23 – Weekly Upgrade Protocol 

9:46 – Outro 

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