March 10, 2025

Butyrate: The Gut's Hidden Fuel Source

11 minutes

Story at-a-glance

Butyrate is a crucial short-chain fatty acid (SCFA) that fuels colon cells, supports gut barrier function, and promotes a balanced microbiome. Colon cells rely on butyrate for up to 80% of their energy needs, helping maintain normal gut function and a healthy intestinal lining
Your gut bacteria produce butyrate by fermenting fiber from whole foods such as fruits, vegetables, legumes and whole grains
Butyrate supports gut barrier integrity by regulating tight-junction proteins and contributing to mucus production, which protects the colon wall
Diet and lifestyle significantly impact butyrate production — a high-fiber diet, exercise, hydration, sleep and avoiding processed fats all support SCFA production
Common misconceptions about butyrate include the idea that fiber supplements alone suffice — whole foods provide a wider variety of fiber, nutrients and benefits. If gut health is compromised, gradual fiber introduction is key — eliminating gut-damaging factors first allows for better microbial balance and butyrate production

...more

By Dr. Mercola

4.6

14881,488 ratings

March 10, 2025

11 minutes

Story at-a-glance

Butyrate is a crucial short-chain fatty acid (SCFA) that fuels colon cells, supports gut barrier function, and promotes a balanced microbiome. Colon cells rely on butyrate for up to 80% of their energy needs, helping maintain normal gut function and a healthy intestinal lining
Your gut bacteria produce butyrate by fermenting fiber from whole foods such as fruits, vegetables, legumes and whole grains
Butyrate supports gut barrier integrity by regulating tight-junction proteins and contributing to mucus production, which protects the colon wall
Diet and lifestyle significantly impact butyrate production — a high-fiber diet, exercise, hydration, sleep and avoiding processed fats all support SCFA production
Common misconceptions about butyrate include the idea that fiber supplements alone suffice — whole foods provide a wider variety of fiber, nutrients and benefits. If gut health is compromised, gradual fiber introduction is key — eliminating gut-damaging factors first allows for better microbial balance and butyrate production

...more