Mastering Nutrition

D-Lactate: Groundbreaking Research No One Is Talking About


Listen Later

D-lactate is commonly stated to be exclusively a microbial metabolite. 

This is found in assumptions within the medical literature for decades even when it was long-known to be false. 

While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes.

In this podcast, moreover, I will argue the following:

Microbial contribution to D-lactate in humans under normal circumstances is negligible. 

I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks alongside the malate-aspartate shuttle and the glycerol phosphate shuttle.

The D-lactate shuttle operates alongside these other shuttles to balance the priorities of conserving cytosolic NAD+, reducing cytosolic acidity, bypassing complex I, or generating ATP. It is uniquely useful as a shuttle when there is an absolute deficit of niacin or NAD(H).

D-lactate is an important contributor to gluconeogenesis that could account for up to 11% of it and rival an individual amino acid.

While D-lactate concentrations in human plasma are infinitesimal, when the downstream metabolism of D-lactate and L-lactate are blocked by genetic disorders, the concentrations of the two forms are similar in plasma. This contrasts wildly with the common claim that flux through D-lactate is “minuscule.” Most likely D-lactate is produced in considerable quantities in liver and kidney but is rarely secreted into plasma because doing so would risk neurotoxicity.

D-lactate should be taken seriously for its potential role in Parkinson’s and in neurological problems generally, for its role in diabetes, and for its extremely underappreciated roles in glycolysis, gluconeogenesis, and the respiratory chain.

Oxalate powerfully impairs D-lactate clearance, so D-lactate should be investigated as a potential link between oxalate and autism, and oxalate-lowering strategies should be seen as a way to improve D-lactate clearance and reduce its potential role in diabetes and neurological disorders.

See the sections on riboflavin, zinc manganese, and glutathione in Testing Nutritional Status: The Ultimate Cheat Sheet, as well as Does CoQ10 Deserve a Spot on Your Longevity Plan? and the How to Detox Manganese guide for managing the relevant nutrients.

Read the written version for live links and references: https://chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research

...more
View all episodesView all episodes
Download on the App Store

Mastering NutritionBy Chris Masterjohn, PhD

  • 4.6
  • 4.6
  • 4.6
  • 4.6
  • 4.6

4.6

412 ratings


More shows like Mastering Nutrition

View all
Boundless Life by Ben Greenfield

Boundless Life

5,001 Listeners

The Human Upgrade: Biohacking for Longevity & Performance by Dave Asprey

The Human Upgrade: Biohacking for Longevity & Performance

7,218 Listeners

The Wellness Mama Podcast by Katie Wells

The Wellness Mama Podcast

3,948 Listeners

Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare by Dr. Michael Ruscio, DC

Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare

775 Listeners

The Energy Blueprint Podcast by Ari Whitten

The Energy Blueprint Podcast

706 Listeners

Dr. Berg’s Healthy Keto and Intermittent Fasting Podcast by Dr. Eric Berg

Dr. Berg’s Healthy Keto and Intermittent Fasting Podcast

1,672 Listeners

Dhru Purohit Show by Dhru Purohit

Dhru Purohit Show

3,475 Listeners

The Dr. Hyman Show by Dr. Mark Hyman

The Dr. Hyman Show

9,289 Listeners

The Melanie Avalon Biohacking Podcast by Melanie Avalon

The Melanie Avalon Biohacking Podcast

631 Listeners

The Energy Balance Podcast by Jay Feldman Wellness

The Energy Balance Podcast

276 Listeners

The Thyroid Fixer by Dr. Amie Hornaman

The Thyroid Fixer

512 Listeners

The Metabolic Classroom with Dr. Ben Bikman by Insulin IQ

The Metabolic Classroom with Dr. Ben Bikman

203 Listeners

The Root Cause Medicine Podcast by Rupa Health

The Root Cause Medicine Podcast

563 Listeners

The Dr. Gabrielle Lyon Show by Dr. Gabrielle Lyon

The Dr. Gabrielle Lyon Show

1,137 Listeners

The Ultimate Human with Gary Brecka by Gary Brecka

The Ultimate Human with Gary Brecka

3,095 Listeners