Dr Ford Brewer - PrevMed

There are several remaining questions to the carb diet issue:

1. is the U-curve real? There is a U-curve that usually inflects at 51%. Most people surveyed get 51% of their calories from carbs.

Other dietary recall studies indicate the same - 51%, even the PURE study.

According to the ARIC follow-up published in Lancet Aug 2018, the lifespan decreases as the % of carbs drops. According to the PURE study, higher levels of carbs showed decreasing lifespan. Why?

Is Glycemic Index, or Glycemic Load involved in the explanation? Is it the quality of the carbs?

2. Also, what happened in the ARIC follow-up to the group that "substituted lower carbs with plant protein and fat"? This subgroup, according to the study also lived longer. It was described in the text and there was a separate table. But it didn't show up in the U curve. Why?

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30135-X/fulltext#seccestitle140

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1989668/

This video covers part 2 of a scientific review article in the respected journal Cell Metabolism by Valter Longo and Satchin Panda. The title subject is Time Restricted Eating, but it covers the science known about other types of fasting as well, including Fasting Mimicking Diet, Periodic Fasting, and the 5;2 diets. The 5 2 Fasting Diet was recently popularized by Jimmy Kimmel, Beyonce, and others. It goes into which ones show a positive impact on which species.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388543/

This video discusses the Omega-3 Index and how to evaluate our EPA, DHA, and other fatty acid levels in our blood.

About John Lorscheider - John is a frequent contributor and has developed and manages our Forum. He’s also a PrevMed patient. Like most of us, John’s family and personal history include significant cardiovascular risk.

About John Lorscheider - John is a frequent contributor and moderator of our YouTube channel. He’s also a PrevMed patient. Like most of us, John’s family and personal history include significant cardiovascular risk. He also developed the PrevMed Community Forum at https://759241a66b89-003789.vbulletin.net/

John came from a technical background and spent his entire career in providing engineered fluid process systems and equipment to industry, as well as performing root cause failure analyses for his customers.

His own study and research made it clear he wasn’t getting the whole story about prevention from his docs. They just didn’t know. So he’s been in several roles of running prevention medical groups to help further the science.

This is the second in a series on Low Carb Dietary Recall Research. Glycemic Index is the impact on blood sugar by foods. The Glycemic Load measures the impact of a meal. Daily Glycemic load would cover and total all food during the day.

Standardized software ( The NDSR - Nutrition Data System for Research) is used by nutritionist interviewers to find matches to the foods. After the food matches are made, the glycemic index must be calculated. That's done using other standard databases (the International Table of Glycemic Index and Glycemic Load Values and the University of Sydney online databases).

After these data are found, calculations have to be made. The frequency and amount of foods ingested must then be calculated. Findings were blinded and replicated. Repeat calculations were found to have a high correlation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1989668/

Lee Hull is a kidney patient. He's writing a book called STOPPING KIDNEY DISEASE. The book is pretty good. It has a great focus on prevention.

He's got a great list of dietary AGE. AGE are proteins (& fats) that are bound covalently (strongly bonded) to glucose or other sugars. Dietary AGE comes mostly from seared meats. Plant sources and uncooked foods have few AGEs.

Unfortunately, he doesn't mention the major source of AGE - hyperglycemia. HgA1c, the well-known marker of blood glucose levels over monthly periods - is actually an AGE. It's the AGE of the hemoglobin molecule. It gets bonded to Glucose in the blood when it is high.

https://kidneyhood.org/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951818/

This is part 2 of a series on Diabetic Glucose Spikes Seen in "Healthy Adults". This video reviews PLOS Biology. Micheal Snyder, head of the genetics department at Stanford, and Heather Hall, a graduate student. They used Continuous Glucose Monitor (CGM). 15% of otherwise "healthy" adults had prediabetes. 2% met the criteria for full-blown diabetes. Age and BMI were major drivers of high variability patterns.

https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2005143

https://www.medscape.com/viewarticle/900134

This video covers the Sevastianova study from the Minerva Foundation in Helsinki. It was published in the American Journal of Clinical Nutrition. It's title Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.

://www.ncbi.nlm.nih.gov/pubmed/22952180

https://academic.oup.com/ajcn/article/96/4/727/4576835

https://pubmed.ncbi.nlm.nih.gov/22975987/

Basically, they added 1000 kcal of simple carbs to the diet of 16 obese individuals. It measured serum indicators of de novo lipogenesis, MRI for liver fat content, and body weight.

They found a 27% increase in liver fat after 3 weeks of adding 1000 kcal of simple carbs. After 6 months of decreased calories and carbs, the liver fat decreased again.

John Lorscheider took Aged Garlic Extract (AGE) based on research he'd seen by Matthew Budoff. John said he got no significant impact on LP-PLA2 until he lost 20 pounds, cut his carbs, and started low-dose Rosuvastatin.

This video reviews the article. It was small (65 total participants) and on intermediate-risk participants (male firefighters). He saw a decrease in hsCRP and a slowing of Coronary Artery Calcification (CAC). This combination in a randomized clinical trial could be a strong signal. But he also saw a drop in the BMI of the study group. I looked again at the study to see if there were randomization irregularities or a discussion of this potential confounder. I could not find anything.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425023/

https://759241a66b89-003789.vbulletin.net/forum/supplement-questions-and-comments/493-chondroitin-sulfate-and-aged-garlic-extract-for-reducing-arterial-inflammation

Vitamin B12 deficiency is increasingly common due to: aging, antacids ( & metformin), vegan/vegetarian/plant-based diets, and failure to recognize it. Inability to digest (malabsorption) is a cornerstone cause, associate with aging, diet, and medications. This video lists these causes go into detail re: the digestion and absorption of Vit B12 and ends with a brief review.