Discover Dr. Mark Hyman’s science-backed roadmap to reverse biological aging and activate your body’s healing system for lifelong vitality.

Dr. Mark Hyman unpacks the emerging science of longevity—how we can grow biologically younger while aging chronologically. He shares how food, hormesis, and mindset affect cellular repair, inflammation, and gene expression. From fasting and saunas to nutrient-rich eating, Dr. Hyman reveals the practical steps to optimize health, reverse aging, and live young forever.

Mark Hyman, MD, has devoted his life to helping others discover optimal health and address the root causes of chronic disease through the power of Functional Medicine. Dr. Hyman is a practicing family physician and an internationally recognized leader, speaker, educator, and advocate in the field of Functional Medicine. He is a co-founder and the Chief Medical Officer of Function Health, founder and Director of The UltraWellness Center, founder of the Cleveland Clinic Center for Functional Medicine, and Board President for Clinical Affairs for The Institute for Functional Medicine.

He is the founder and chairman of the Food Fix Campaign, dedicated to transforming our food and agriculture system through policy. Dr. Hyman is also the host of one of the leading health podcasts, The Dr. Hyman Show, with 250+ million downloads and a fifteen-time New York Times best-selling author. He is a regular medical contributor to several television shows and networks, including CBS's This Morning, Today, Good Morning America, The View, Fox and CNN.

Dr. Ellen Vora explains false vs. true anxiety, root causes like sleep, nutrition, and gut health, and practical tools for relief and resilience.

Dr. Ellen Vora breaks down the concept of false versus true anxiety, offering a practical roadmap to identify and address avoidable anxiety triggers such as blood sugar crashes, nutrient deficiencies, caffeine, alcohol, and poor sleep hygiene. She explores the role of gut health, inflammation, and circadian rhythm in mood regulation and introduces tools for processing deeper, true anxiety—including mindfulness, ritual, and integration practices. Dr. Vora also reflects on spirituality, psychedelics, and reclaiming intuition as part of modern mental health.

Dr. Ellen Vora is a board-certified psychiatrist, acupuncturist, and author of “The Anatomy of Anxiety”. She has become a leading voice in redefining mental health by bridging conventional psychiatry with holistic approaches. Dr. Vora’s work emphasizes distinguishing false anxiety—avoidable, physiologically driven states—from true anxiety, which reflects deeper meaning and alignment. Through her clinical practice, writing, and speaking, she equips people with tools ranging from nutrition and sleep strategies to rituals, spirituality, and mindful use of psychedelics to foster resilience and healing.

Dr. Michael Klaper explains how excess salt raises blood pressure, the role of salt sensitivity, and plant-based strategies to reverse hypertension.

Dr. Michael Klaper explores the complex relationship between sodium, kidney function, and blood pressure. He explains why modern diets overwhelm our delicate sodium balance, how salt sensitivity affects hypertension risk, and why excess sodium damages the heart, kidneys, and blood vessels. Dr. Klaper also offers practical tips for reducing salt, discusses iodine intake, and emphasizes the powerful role of plant-based nutrition in reversing high blood pressure and supporting long-term health.

Dr. Michael Klaper is a physician, author, and educator who has been a leading advocate for plant-based nutrition and lifestyle medicine for over four decades. A true pioneer in preventive health, he has inspired countless patients and practitioners to embrace nutrition as a cornerstone of healing. Through his Moving Medicine Forward initiative, Dr. Klaper teaches medical students the essential role of food in reversing chronic disease. His lifelong mission is to empower individuals to thrive through whole-food, plant-based living while helping reshape medicine to focus on true healing.

Ray Solano shares how novel delivery systems improve absorption of methylene blue, LDN, and hormones to support Lyme and chronic illness care.

Ray Solano, head of PD Labs, introduces an innovative drug delivery system that makes powerful compounds more effective and better tolerated. He explains how nanoscale, phospholipid-encapsulated formulations dramatically improve absorption of methylene blue, testosterone, and low-dose naltrexone—allowing patients to benefit from lower doses with fewer side effects. This approach offers exciting promise for chronic illness, Lyme disease, and hormone therapies.

Ray Solano is the President of PD Labs, a compounding pharmacy specializing in advanced delivery systems for complex medications and nutraceuticals. With decades of experience, he has pioneered novel formulations that increase absorption and reduce side effects of therapies such as methylene blue, low-dose naltrexone, and hormones. Through collaborations with physicians and researchers, Ray is helping to transform chronic illness treatment with safe, effective, and patient-centered innovations.

Dr. Isaac Jones shares longevity strategies, mitochondrial health insights, and breakthrough nutrients to slow aging and boost vitality.

Dr. Isaac Jones joins Dr. David Jockers to explore the science of longevity, mitochondrial health, and anti-aging breakthroughs. He explains the hallmarks of aging, the role of oxidative stress and fibrotic tissue in chronic disease, and how lifestyle strategies can decelerate the aging process. Dr. Jones also introduces powerful nutrients—including glutathione, CoQ10, and urolithin A—and reveals how his ultimate longevity stack is designed to simplify supplementation, optimize mitochondria, and help people extend both lifespan and healthspan.

Dr. Isaac Jones is a leading longevity and functional health expert dedicated to transforming how people age. Known for his work on mitochondrial health, epigenetics, and advanced supplementation, he helps clients worldwide extend both lifespan and healthspan. Dr. Jones is the founder of Elevays and co-creator of the Ultimate Longevity Stack, a breakthrough nutrient system designed to target all hallmarks of aging. With over two decades of experience, he combines research-backed science with personalized lifestyle medicine to help people thrive at every stage of life.

Dr. Orville Kolterman explains how the gut microbiome, probiotics, and GLP-1 pathways support blood sugar balance and type 2 diabetes management.

Dr. Orville Kolterman dives into the critical role of the gut microbiome in blood sugar regulation and type 2 diabetes. He explains how butyrate-producing bacteria and Akkermansia protect gut integrity, regulate GLP-1, and reduce cravings while improving insulin sensitivity. He also highlights Pendulum’s probiotic formulations, which combine science-backed strains with prebiotic fibers to restore balance, support metabolic health, and empower people with type 2 diabetes to achieve better glucose control.

Dr. Orville Kolterman is an endocrinologist with decades of experience in diabetes research, drug development, and clinical care. A former faculty member at the University of California, San Diego, he helped pioneer peptide-based therapies, including the first GLP-1 analog for metabolic disease. After transitioning from biotech, he joined Pendulum as Chief Medical Officer, where he has spent the last ten years advancing microbiome-based solutions for type 2 diabetes. His work continues to bridge science and practice, empowering people to manage blood sugar better through innovative approaches.

Dr. Jason Fung explains how fasting reverses diabetes, activates autophagy, protects muscle, and supports longevity better than drugs.

Dr. Jason Fung reveals why fasting is one of the most powerful tools for weight loss, diabetes reversal, and longevity. He explains how it lowers insulin, activates autophagy, and protects muscle strength—while also reducing cancer risk. He also shares why fasting mimicking diets may provide equal or greater benefits than water-only fasts and how lifestyle choices like diet, exercise, community, and purpose build true longevity.

Dr. Jason Fung is a physician (kidney specialist), researcher, and New York Times best-selling author currently practicing in Toronto, Canada. Trained in Los Angeles and Toronto, and currently practices as a nephrologist (kidney specialist). His books, including The Obesity Code, The Complete Guide to Fasting, The Diabetes Code, and The Cancer Code, have challenged conventional thinking about these diseases and introduced dietary strategies to manage them. He is the co-founder of The Fasting Method (www.TheFastingMethod.com), which provides the education, tools, and community needed to implement intermittent fasting successfully.

Dr. Jason Fung explains how fasting reverses diabetes, activates autophagy, protects muscle, and supports longevity better than drugs.

Dr. Jason Fung reveals why fasting is one of the most powerful tools for weight loss, diabetes reversal, and longevity. He explains how it lowers insulin, activates autophagy, and protects muscle strength—while also reducing cancer risk. He also shares why fasting mimicking diets may provide equal or greater benefits than water-only fasts and how lifestyle choices like diet, exercise, community, and purpose build true longevity.

Dr. Jason Fung is a physician (kidney specialist), researcher, and New York Times best-selling author currently practicing in Toronto, Canada. Trained in Los Angeles and Toronto, and currently practices as a nephrologist (kidney specialist). His books, including The Obesity Code, The Complete Guide to Fasting, The Diabetes Code, and The Cancer Code, have challenged conventional thinking about these diseases and introduced dietary strategies to manage them. He is the co-founder of The Fasting Method (www.TheFastingMethod.com), which provides the education, tools, and community needed to implement intermittent fasting successfully.

Dr. Michael Greger shares how diet, cholesterol, statins, stents, and supplements affect heart disease—and what truly protects cardiovascular health.

Dr. Michael Greger joins the conversation to discuss the science of heart disease prevention and reversal. He explains why maintaining low LDL cholesterol over a lifetime is key, critiques the overuse of statins and stents, and dives into controversial topics like taurine, fish oil, and stroke risk in plant-based diets. With insights from his books How Not to Die and How Not to Age, he highlights how daily lifestyle choices—not pills or procedures—offer the greatest protection for heart health.

A founding member and Fellow of the American College of Lifestyle Medicine, Michael Greger, M.D., is a physician and internationally recognized speaker on nutrition. His science-based nonprofit, NutritionFacts.org, offers a free online portal hosting more than 2,000 videos and articles on myriad health topics. Dr. Greger is a sought-after lecturer and has presented at the Conference on World Affairs and the World Bank, testified before Congress, and was invited as an expert witness in Oprah Winfrey’s defense in the infamous “meat defamation” trial—a graduate of Cornell University School of Agriculture and Tufts University School of Medicine. Dr. Greger is also an acclaimed author. How Not to Die, The How Not to Die Cookbook, How Not to Diet, and How Not to Age became instant New York Times Best Sellers. More than a million copies of How Not to Die have been sold. All proceeds Dr. Greger receives from the sales of his books and speaking honoraria are donated directly to charity.

Dr. Anna Cabeca reveals how to restore intimacy, balance hormones, and embrace oxytocin after breast cancer through nutrition, detox, and empowerment.

Dr. Anna Cabeca shares her journey from conventional gynecology to integrative women’s health, sparked by patients who refused to accept a life without intimacy after breast cancer. She explains the dangers of hormone disruptors, the importance of vitamin D, and how gut health and bioidentical hormone replenishment create resilience. She also highlights oxytocin as the true hormone of longevity and how small daily choices can reignite joy, purpose, and connection.

Anna Cabeca, DO, OBGYN, FACOG, is the best-selling author of The Hormone Fix and Keto-Green 16 and MenuPause. Dr. Anna is triple-board certified and a fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She holds special certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She lectures frequently on these topics throughout the world to large audiences and is known nationally as The Girlfriend Doctor and is the host of The Girlfriend Doctor show. She has personally developed natural products to help women balance hormones and thrive through menopause, including the highly acclaimed Julva® cream for the vulva and MightyMaca® Plus, a powerful superfood blend. She now lives in Dallas with her daughters, horses, and dogs.