What if chronic disease, cognitive decline, and even trauma were not fixed conditions—but modifiable biological states?

In this Functional Forum episode, James Maskell and Matt Wiggins bring together leading clinicians and researchers to explore the frontiers of precision and functional medicine.

They discuss SUPAR, a powerful biomarker for systemic inflammation that could reshape early disease detection. The conversation then turns to a groundbreaking cognitive decline trial showing major improvements in patients treated with functional medicine protocols compared to standard care.

The episode also explores the biology of loneliness and the "cell danger response," the reversibility of trauma through epigenetic mechanisms and psychedelic-assisted therapy, and emerging ideas about measuring masculinity as a clinical health indicator.

Together, these insights point toward a future where chronic disease may be detected earlier, treated systemically, and in some cases reversed.

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About the Guests:

This episode features multiple leading voices from the Functional Forum community, including clinicians and researchers in functional and precision medicine:

Matt Wiggins – Health innovator focused on bringing advanced biomarker testing, including SUPAR, into clinical practice

Dr. Kat Toups – Clinician involved in cognitive decline research using precision functional medicine approaches

Dr. Molly Maloof – Physician and educator specializing in metabolic health, loneliness biology, and cellular stress responses

Dr. David Rabin – Psychiatrist and neuroscientist studying trauma, epigenetics, and psychedelic-assisted therapy

Dr. Brad Jacobs – Clinician exploring novel frameworks for men's health and masculinity as a clinical metric

Dr. Ryan Adler – Advocate for integrating cognitive health protocols into mainstream clinical practice

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Social Handles:

Website: https://www.jamesmaskell.com/

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Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

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