In this episode, Dr. Daina Parent, ND, sits down with Laurence Katsaras—Naturopath, Acupuncturist, and classically trained Western Herbalist—for a deep dive into incretin hormones, especially GLP-1's and their far-reaching effects on the body. They discuss the interconnected web of health in which all physiological pathways work together, and how GLP-1 medications can distort this web leading to unintended effects elsewhere. They highlight clinical takeaways for keeping the web strong through hormone balance, gut health, herbs, diet, and lifestyle.

They explore the pros and cons of GLP-1 receptor agonist medications, herbal and lifestyle recommendations to help manage side effects, and natural approaches that support the body's own ability to regulate these pathways. Laurence also shares insights from his 20 years in the natural medicine industry as a clinician, researcher, and educator. A sought-after speaker in the naturopathic and complementary medicine field across Australia and New Zealand, he is known for translating emerging research into practical, actionable strategies for clinical practice.

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Highlights of the episode include:

• GLP-1 medication effects vs. the body's natural GLP-1 hormone activity
• Risks for women in perimenopause, menopause, and postmenopause: muscle loss and bone health impacts
• Herbal compounds that stimulate GLP-1 receptors naturally
• The complex web of health: restoring balance in interconnected physiological systems
• Broad benefits of bitter herbs on the gut microbiome as part of a holistic approach to metabolic health

Podcast Summary

• 1:30 Defining incretin hormones, including GLP-1 (glucagon-like peptide-1)
• 5:06 Organs that are influenced by incretin hormones, and how are they affected
• 7:48 GLP-1 medication effects vs. the body's natural GLP-1 hormone activity
• 8:53 Side effects of GLP-1 receptor agonist medications
• 11:00 Concerns about weight loss, muscle loss and rebound weight gain after discontinuing medication
• 15:30 Importance of continuing holistic diet and lifestyle habits after going off medications
• 18:20 Risks for women in perimenopause, menopause, and postmenopause: muscle loss and bone health impacts
• 20:07 Herbal compounds that stimulate GLP-1 receptors naturally—gentle, holistic alternatives without dramatic or rapid changes
• 29:00 How bitter herbs and foods stimulate incretin hormone production naturally
• 30:30 Herbs with metabolic benefits and that support GLP-1 function
• 32:25 Is long-term GLP-1 medication use sustainable considering side effects and costs? Harnessing the body's innate ability to rebalance
• 33:30 The complex web of health: restoring balance in interconnected physiological systems
• 36:22 Discontinuation rates of GLP-1 medications: potential for combining herbal approaches with medication
• 39:00 Herbal safety: choosing the right herb for the right person, only when truly needed
• 41:14 Broad benefits of bitter herbs on the gut microbiome as part of a holistic approach to metabolic health
• 47:10 The "interconnected web of health"—how a single strand impacts the whole system
• 49:20 Clinical guidance for supporting patients considering or currently taking GLP-1 medications