Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat.

This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions:

• Protein and Longevity
• Why is an IV more hydrating than salted water?

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

• Does which food you eat matter when everything is digested anyway?
• How to know if your nitric oxide is dilating your blood vessels properly?
• How big of a problem are transient glucose spikes above 140 mg/dL?
• Can I take too much collagen?
• What is the maximum dose of cod liver oil safe to use long-term?
• How much A is safe to take when I need so much to resolve my symptoms?
• Generalizing from cell studies of green tea catechins to cups of green tea per day.
• What to do about lumbar discs bulging?
• Why would vitamin K2 cause a nosebleed?
• How to balance A with D when I react poorly to D and need so much A?
• Why would COVID decrease HRV long-term?
• How to raise secretory IgA?
• Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.