Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision.  

- Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

- Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ 

Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. 

Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. 

This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. 

You'll Learn: 

• How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy 
• Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment 
• How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually 
• What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot 
• Why cell viability and placement matter more than raw cell count, and how RMI measures both 10 minutes before every injection 
• How orthopedic stem cell protocols achieve 82.5 percent improvement in joint function across 8,000 treated joints 
• Why Dave calls RMI the best hardware upgrade available and 40 Years of Zen the best software upgrade, and how the two work together 
• What the difference feels like between going from standard resolution to 4K inside your own brain 

Thank you to our sponsors!     

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Victor Urzola, RMI Clinic Costa Rica, stem cell therapy, brain optimization, neurocognitive protocol, focused ultrasound, transcranial magnetic stimulation, neuroinflammation, plasmapheresis, orthopedic stem cells, mesenchymal stem cells, blood brain barrier, regenerative medicine, anti-aging, longevity, biohacking, Dave Asprey, erectile dysfunction treatment, stem cell facelift, human performance 

Resources:   

• Learn More About All Of The Treatments at RMI by visiting: https://daveasprey.com/rmi/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

01:02 – Introduction and RMI Overview 

03:02 – Cognitive Protocol Explained 

05:39 – Dave's Brain Treatment Experience 

13:08 – RMI Results & Patient Outcomes 

15:32 – Plasmapheresis (Blood Cleanse) 

17:10 – Orthopedic Stem Cell Treatments 

23:49 – Enhanced Protocol (Sexual Health – Men) 

25:29 – Sexual Health – Women 

27:40 – Facial Stem Cell Treatment 

30:05 – Closing & Resources 

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