Question: If I use SAMe for depression, what do I need for nutritional balance?

Nutrition wise, I think the most important thing would be to make sure that you have an adequate glycine status. And you know, I don't know what your background is in terms of other issues, but the glycine buffer system, which is how you buffer excess methyl groups, which is what you would have if you take a large bolus of SAMe.Other nutritional concern would be having enough molybdenum. Generally, you're gonna have enough with 100 mcg a day. If you're eating liver once a week, you probably have enough, but there's no harm in taking like 500 mcg a day, so not really a problem if you want to supplement there just to make sure it's not an issue. 

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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