Commune with Jeff Krasno

Is This Right for Me? NAD+: Why the "Longevity Molecule" Story Just Got Complicated

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NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on.


In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits.


You’ll learn about:

  • What NAD+ does in the body and why it got tied to aging
  • The new research questioning whether NAD+ truly declines with age
  • Oral NR and NMN versus IV infusions, and what the evidence supports
  • The risks rarely mentioned, including the cancer question
  • Why the saline, B vitamins, and forced rest may explain how good people feel

    • This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first.


    This episode was made possible by:

    • LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at drinklmnt.com/commune.
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