This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down the essentials of a true metabolic workup. This episode moves beyond social media diet trends and digs into the science behind comprehensive lab panels, what they measure, and why they matter for your whole-body health. 

Dr. Cooper explains how to interpret common and advanced metabolic markers—like blood sugar, insulin, cholesterol, hormone levels, and more—while Andrea and Mark share personal insights into the power of understanding your metabolic baseline. If you’re concerned about weight, diabetes, or just want to know your numbers, this episode gives you the knowledge to talk confidently with your healthcare provider.

Key Takeaways:

• A whole-body metabolic approach goes beyond just weight or blood pressure—comprehensive lab work (plus family history) is essential to uncover risks or dysfunction early.
• Standard blood panels provide useful clues (glucose, cholesterol, liver, kidney, blood pressure), but advanced tests (A1C, lipid particles, hormone levels, inflammation markers) round out the picture.
• Metabolic dysfunction is driven by factors far deeper than calories in/out—dieting and under-fueling can actually weaken metabolism over time.
• Medication for metabolic health is not a failure; it’s a science-backed intervention. Early and accurate testing allows for better, evidence-based treatment.
• Don’t ignore “borderline” results—addressing issues early is easier and more effective than trying to reverse advanced dysfunction later.

Personal Stories & Practical Advice:

• Andrea recounts her life-changing journey from endless dieting to real answers through complete metabolic testing and individualized treatment.

• Mark highlights the need for patients to advocate for themselves and ask for more than just the standard panel at annual exams.

References:

Diet Failure Rate

• Mann, T., et al. (2007). "Medicare's search for effective obesity treatments: diets are not the answer." American Psychologist, 62(3), 220-233

• Anderson, J. W., et al. (2001). "Long-term weight-loss maintenance: a meta-analysis of US studies." American Journal of Clinical Nutrition, 74(5), 579-584

Persistent Metabolic Adaptation

• Fothergill, E., et al. (2016). "Persistent metabolic adaptation 6 years after 'The Biggest Loser' competition." Obesity, 24(8), 1612-1619

• Rosenbaum, M., & Leibel, R. L. (2010). "Adaptive thermogenesis in humans." International Journal of Obesity, 34(S1), S47-S55

Long-Term Hormonal Disruption

• Sumithran, P., et al. (2011). "Long-term persistence of hormonal adaptations to weight loss." New England Journal of Medicine, 365(17), 1597-1604

• Rosenbaum, M., et al. (2005). "Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight." Journal of Clinical Investigation, 115, 3579-3586

Weight Cycling Cardiovascular Risks

• Montani, J. P., et al. (2006). "Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory." International Journal of Obesity, 30(S4), S58-S66

Resources:

• Connect with Dr. Emily Cooper on LinkedIn
• Connect with Mark Wright on LinkedIn
• Connect with Andrea Taylor on Instagram

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected] or [email protected]

Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org