Modern Healthspan

In this episode Dr Tanzi discusses whether Alzheimer's and other brain diseases are happening at a younger age and why that might be, along with his own protocol to maintaining a young and healthy mind!

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.

Professor Tanzi's page at Harvard

https://brain.harvard.edu/?people=rudolph-e-tanzi

Books by Professor Tanzi

https://amzn.to/3kyqxVQ

Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

https://amzn.to/3zsenSl

The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life

https://amzn.to/3kwwwKx

Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being

https://amzn.to/3zx5h6Q

Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Dr Tanzi talks about some of the future potential options are to treat Alzheimer's once it has started and neural inflammation has set in.

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.

Professor Tanzi's page at Harvard

https://brain.harvard.edu/?people=rudolph-e-tanzi

Books by Professor Tanzi

https://amzn.to/3kyqxVQ

Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

https://amzn.to/3zsenSl

The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life

https://amzn.to/3kwwwKx

Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being

https://amzn.to/3zx5h6Q

Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Tanzi talks about SHIELD, his acronym for the things that you can do to protect your brain. S - Sleep, H - Handle Stress, I - Interactions with friends, E - Exercise, L - Learn new things and D - Diet and we dive into detail on a few of them.

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.

Professor Tanzi's page at Harvard

https://brain.harvard.edu/?people=rudolph-e-tanzi

Books by Professor Tanzi

https://amzn.to/3kyqxVQ

Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

https://amzn.to/3zsenSl

The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life

https://amzn.to/3kwwwKx

Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being

https://amzn.to/3zx5h6Q

Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Tanzi talks about the causes of Alzheimer's, from the plaques and tangles to neural inflammation, and what treatments exist for these symptoms.

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.

Professor Tanzi's page at Harvard

https://brain.harvard.edu/?people=rudolph-e-tanzi

Books by Professor Tanzi

https://amzn.to/3kyqxVQ

Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

https://amzn.to/3zsenSl

The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life

https://amzn.to/3kwwwKx

Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being

https://amzn.to/3zx5h6Q

Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.

Professor Tanzi's page at Harvard

https://brain.harvard.edu/?people=rudolph-e-tanzi

Books by Professor Tanzi

https://amzn.to/3kyqxVQ

Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

https://amzn.to/3zsenSl

The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life

https://amzn.to/3kwwwKx

Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being

https://amzn.to/3zx5h6Q

Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discusses the attitude of governments to aging, the most promising aging technologies and her personal protocol for staying healthy.

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discusses her company Senisca, her theory of aging and getting funded for aging research

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discusses how oligonucleotides can be used for as a very precise way to control gene expression.

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discuss how she and her team used resveralogs initially and later HS2 donors to change the regulation of splicing factors and in doing so, reverse cellular senescence. We also touch on what a therapy based on this might look like in the clinic.

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discuss whether RNA Splicing meets the criteria of a hallmark of aging. To qualify it should i) manifest during normal aging ii) its aggravation should accelerate aging and iii) it amelioration should slow or reverse aging. Prof Harries goes through each of these criteria with respect to RNA splicing.

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/