Modern Healthspan

Genetics professor Dr. Jan Vijg explains how DNA damage causes aging and why human lifespan may be limited to 115 years. Learn about the 100,000 DNA hits your cells take daily, breakthrough research on the DREAM gene complex that could slow mutation accumulation, and whether we can extend maximum lifespan.

In this conversation, Dr. Jan Vijg, Professor and Chair of Genetics at Albert Einstein College of Medicine, explains how genome instability drives the aging process. We explore how your cells sustain 100,000 DNA lesions daily, the difference between DNA damage and somatic mutations, and why mutations accumulate exponentially with age.

Dr. Vijg discusses his controversial 2016 Nature paper arguing human maximum lifespan is capped at 115 years, and why mean lifespan improvements don't translate to breaking this limit. He shares exciting new research on the DREAM gene complex - a potential master regulator that could enhance DNA repair across multiple pathways simultaneously.

Key topics include: how DNA repair systems decline with age, why long-lived species have better repair mechanisms, tissue-specific mutation rates, the role of SIRT6 and NAD in DNA repair, rare genetic variants in centenarians, and whether pharmacological interventions could slow aging at the cellular level.

🌐Links in this video

Dr Vijg's page at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/11318/jan-vijg

Evidence for a limit to human lifespan https://pubmed.ncbi.nlm.nih.gov/27706136/

The DREAM complex links somatic mutation, lifespan, and disease https://www.biorxiv.org/content/10.1101/2025.09.15.676396v1.full

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Holistic dentist Dr. Namrata Patel reveals how your oral microbiome predicts heart disease, Alzheimer's, and cancer 10-13 years before symptoms appear. Learn about saliva testing, the bacteria that cause systemic inflammation, why tongue exercises reduce sleep apnea 30%, and the daily protocol that protects your healthspan.

In this conversation, holistic dentist Dr. Namrata Patel explains how your mouth is an early warning system for chronic disease. We explore the specific bacteria that cause heart attacks, diabetes, cancer, and Alzheimer's - and how saliva testing can detect these risks years before blood tests show problems.

Dr. Patel shares breakthrough research on myofunctional therapy, showing how simple tongue exercises can reduce sleep apnea by 30%. We discuss the connection between dry mouth, nitric oxide production, and systemic inflammation, plus why conventional mouthwash may be destroying beneficial bacteria.

Key topics include: the optimal daily oral care protocol, how to monitor your oral health at home, the truth about root canals and hidden infections, when to see a functional dentist versus conventional dentist, and why oral health becomes more critical after age 40. Whether you have perfect teeth or chronic health conditions, this episode reveals how your mouth impacts your longevity.

🌐Links in this video

Green Dentistry Home Page https://sfgreendentist.com/

Dr Patel's book on Amazon:

Age With Style: Your Guide To A Youthful Smile & Healthy Living https://amzn.to/49AdQn5

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Clinical psychologist Dr. Lloyd Glauberman reveals why smart, motivated people struggle to maintain healthy habits - and the 3 things you knew as an infant that could transform your health. Learn about lifestyle intelligence, the metabolism changes after 40, and why sustaining change is harder than starting.

In this conversation, clinical psychologist Dr. Lloyd Glauberman explains the hidden psychological barriers preventing lasting health changes. We explore how family and culture "hypnotically" program us away from natural eating, sleeping, and movement patterns we understood as infants.

Dr. Glauberman introduces the concept of Lifestyle Intelligence - managing the three core elements of health: nutrition, sleep, and exercise. He explains why metabolism slows with age, causing 20+ pound weight gain even without behavior changes, and shares practical strategies for sustaining lifestyle modifications long-term.

Key topics include: the role of sleep as the "lynchpin" for health, why perfectionism sabotages progress, how digital devices create modern trance states, and the surprising calculation showing how every meal adds or subtracts time from your life. Whether you're struggling to start or maintain health changes, this episode provides actionable psychological insights for lasting transformation.

🌐Links in this video

Lifestyle Intelligence website https://lifestyleintelligencelq.com/

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Duke Professor reveals how 90-year-olds tripled their muscle strength in just 10 weeks - and why we've been measuring muscle mass wrong for decades. Dr. William Evans explains the revolutionary new test that predicts disability, mortality, and even Alzheimer's risk. Learn the exact protocols for maintaining muscle mass as you age, the truth about protein requirements, and why your doctor isn't testing for sarcopenia. Plus: critical warnings about GLP-1 weight loss drugs and muscle loss in older adults.

Dr. William Evans is a professor of medicine at Duke University whose pioneering research established sarcopenia as a recognized medical condition. In this episode, he reveals groundbreaking findings about muscle mass and aging that challenge decades of scientific assumptions.

Dr. Evans explains why traditional methods like DEXA scans have been measuring the wrong thing, and introduces his revolutionary creatine-based test that accurately measures muscle mass with just a single urine sample. His research on over 4,000 people proves that muscle mass is central to how we age - affecting everything from physical disability to cognitive function and mortality risk.

We discuss practical strategies for maintaining muscle, including resistance training protocols, optimal protein intake for older adults, and the concerning effects of GLP-1 weight loss drugs on muscle preservation. Dr. Evans also shares insights on hormone therapy, the future of muscle-building drugs, and why exercise remains the single most important intervention for healthy aging and Alzheimer's prevention.

🌐Links in this video

Dr Evans page at Duke University https://medicine.duke.edu/profile/william-joseph-evans

Short Physical Performance Battery https://www.physio-pedia.com/Short_Physical_Performance_Battery

MyoCorp website https://myocorps.com/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

44% of supplements FAIL testing! Dr. Glenn, Head of Science at SuppCo, reveals which supplements don't contain what they say, how to spot red flags, and why even expensive brands might be lying about what's in the bottle. Learn the 3 essential rules before buying ANY supplement.

Think your supplements contain what they claim? Think again. Dr. Glenn, Head of Science at SuppCo, drops a bombshell: 44% of supplements they've tested have failed - meaning they contain less than 95% of the active ingredient listed on the label. Many have ZERO active ingredients at all.

In this eye-opening interview, Dr. Glenn exposes the dark side of the $70 billion supplement industry, including creatine gummies on Amazon with no creatine, urolithin A products with less than 1% of the active ingredient, and why products with better reviews often contain nothing at all.

Learn which certifications actually matter (NSF, USP, cGMP), the red flags to watch for when shopping, why gummies are particularly risky, and how SuppCo's trust score system helps consumers navigate the overwhelming world of supplements. Plus, get Dr. Glenn's 3 essential tips every supplement buyer needs to know before making their next purchase.

🌐Links in this video

SuppCo website : https://supp.co/home/today

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Methylene blue was the first synthetic medicine ever created. 140 years later, we're discovering it might be one of the most powerful tools for brain health and longevity. Here's what the research actually shows.

Dr. Francisco Gonzalez-Lima has spent decades researching methylene blue, the first synthetic medicine in history. In this conversation, he explains how this unique compound enhances mitochondrial function, increases cellular energy production, and reduces oxidative stress; all at very low doses.

We discuss the critical importance of dose (low dose benefits, high dose harms), why pharmaceutical-grade purity matters, and how to personalize your dosing using a simple urine test. Dr. Gonzalez-Lima also addresses common misconceptions from failed Alzheimer's trials and explains why those studies used the wrong approach.

Looking ahead, he shares his plans to combine methylene blue with near-infrared light therapy and MCT oil for his upcoming clinical trial on mild cognitive impairment. Whether you're interested in cognitive enhancement, neuroprotection, or healthy aging, this is essential viewing.

🌐Links in this video

Dr Gonzalez-Lima's page https://liberalarts.utexas.edu/psychology/faculty/fg

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Hearing loss isn't just about your ears—it's about your brain. Dr. Ben Thompson reveals how treating hearing loss can reduce cognitive decline by 48% and shares breakthrough protocols for tinnitus recovery that actually work.

Audiologist Dr. Ben Thompson explains the critical connection between hearing health and cognitive function, discussing the landmark ACHIEVE study that showed hearing treatment reduced cognitive decline by 48% in at-risk older adults.

Learn how the ear and brain work together, what causes age-related hearing loss, and why the cochlea's hair cells don't regenerate. Dr. Thompson covers the biggest threats to your hearing (hint: it's not just aging), how to protect yourself from noise damage, and the truth about tinnitus, including why most people are told there's nothing they can do when effective treatments exist.

Discover how modern hearing aid technology has evolved beyond bulky devices to sleek, smartphone-integrated systems that actively separate speech from background noise. Whether you're experiencing hearing changes yourself or have aging family members, this conversation offers practical insights on preserving both hearing and cognitive health for the long term.

🌐Links in this video

Treble Health web page: https://treblehealth.com/

Treble Health YouTube Channel https://www.youtube.com/@treblehealth

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial

https://pubmed.ncbi.nlm.nih.gov/37478886/

The ACHIEVE study page https://www.achievestudy.org/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

NAD+ Anti-Aging Breakthrough: How This Molecule Could Reverse Aging and Treat Alzheimer's Disease | Clinical Trial Results from Leading Longevity Researcher Dr. Evandro Fang

Some links are affiliate links so we will earn a commission when they are used to purchase products.

Dr. Evandro Fang from the University of Oslo reveals groundbreaking research on NAD+ and its role in combating aging and neurodegenerative diseases. In this interview, Dr. Fang discusses his lab's pioneering work on mitophagy (mitochondrial cleanup) and how NAD+ precursors like NR and NMN have shown remarkable results in clinical trials for premature aging disorders. He shares dramatic case studies, including a 3-year-old Austrian boy who regained motor skills after NAD+ treatment, and explains the molecular mechanisms behind aging at the cellular level. The conversation covers his upcoming Phase 2 clinical trial using Urolithin A for Alzheimer's disease, the challenges of translating longevity research into approved therapies, and combination approaches involving exercise and caloric restriction. Dr. Fang provides practical insights into current NAD+ supplementation evidence while addressing safety concerns and optimal dosing strategies. This technical but accessible discussion offers valuable perspectives on the future of anti-aging medicine and therapeutic interventions for age-related diseases.

🌐Links in this video

Dr Fang's page https://evandrofanglab.com/

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Could a simple supplement that bodybuilders use to build muscle actually help fight Alzheimer's disease? Dr. Matthew Taylor from the University of Kansas reveals surprising results from her groundbreaking clinical trial testing high-dose creatine in Alzheimer's patients

In this episode, Dr. Matthew Taylor discusses his pioneering research on creatine supplementation for Alzheimer's disease, addressing a critical gap in brain energy metabolism that worsens with aging and becomes severely impaired in dementia. His 8-week clinical trial gave 20 Alzheimer's patients 20 grams of creatine daily - a bodybuilder's loading dose - and found remarkable improvements in memory, executive function, and even unexpected gains in reading comprehension. Using advanced MRI spectroscopy, his team confirmed that creatine actually reaches the brain, increasing levels by 11%. Beyond cognitive benefits, participants also showed significant improvements in hand grip strength and muscle mass. Dr. Taylor explains how brain energy metabolism creates a vicious cycle in Alzheimer's, explores whether creatine could prevent dementia in healthy aging, and reveals his plans for combining creatine with ketogenic diet approaches. This conversation offers hope for a simple, accessible intervention that could help millions facing cognitive decline.

🌐Links in this video

Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition

https://pmc.ncbi.nlm.nih.gov/articles/PMC12089086/

Dr Taylor's website at Kansas University https://www.kumc.edu/mtaylor3.html

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

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A potential functional cure for HIV could be just months away from human trials. Dr. Lanna reveals how her company Sentcell is using cellular rejuvenation to eliminate HIV reservoirs—and the surprising anti-aging benefits that come with it.

n this groundbreaking interview, Dr. Lanna, founder and CEO of Sentcell, explains how his team has developed a revolutionary approach to HIV treatment that could eliminate the need for lifelong antiretroviral therapy. Unlike traditional strategies that target the virus directly, Sentcell's method uses a molecule called DOS to rejuvenate CD4 T-cells, triggering them to naturally clear HIV DNA from their own genomes through a process that mimics elite controllers—rare individuals who can suppress HIV without medication. The treatment works by reactivating dormant cellular pathways that outcompete HIV's integration machinery, effectively reversing viral integration and clearing infected cells within days to weeks. Beyond HIV, Dr. Lanna discusses his team's discovery of "rivers of telomeres"—vesicle structures released by rejuvenated T-cells that can systemically rejuvenate other organs and extend lifespan by 12-17 months in animal studies. With Phase 1 human trials planned for 2026 at University College London, this research represents a potential paradigm shift from managing HIV as a chronic condition to achieving a functional cure.

🌐Links in this video

Sentcell website https://sentcell.life/

Dr Lanna on LinkedIn https://www.linkedin.com/in/professor-alessio-lanna-ph-d-687a1bb1/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan