Modern Healthspan

When someone's LDL cholesterol hits 574 mg/dL, doctors typically expect the worst. But what if everything we think we know about cholesterol and heart disease risk is incomplete?

In this episode, I sit down with researchers Nick Norwitz, Adrian Soto-Mota, and Dave Feldman to discuss their groundbreaking study on lean mass hyperresponders - a rare population who develop extremely high LDL cholesterol on ketogenic diets despite being lean, fit, and metabolically healthy. Their recent paper "Plaque Begets Plaque, ApoB Does Not" challenges conventional wisdom by showing that in this unique population, neither LDL cholesterol nor ApoB levels predicted plaque progression over one year of follow-up. Instead, existing plaque was the strongest predictor of future plaque growth. We explore the proposed lipid energy model that may explain why some people's cholesterol skyrockets on keto, discuss the limitations and implications of their findings, and examine what this means for personalized cardiovascular risk assessment. This conversation touches on fundamental questions about causality in medicine, the importance of studying outlier populations, and why a one-size-fits-all approach to cholesterol management may be missing crucial nuances.

🌐Links in this video

Longitudinal Data From the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not https://pubmed.ncbi.nlm.nih.gov/40192608/

Citizen Science Foundation https://citizensciencefoundation.org/

Nick's home page https://www.nicknorwitz.com/

On X

Nick Nowitz https://x.com/nicknorwitz

Dave Feldman https://x.com/realDaveFeldman

Adrian Soto-Mota https://x.com/AdrianSotoMota

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Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach.

Some links are affiliate links so we will earn a commission when they are used to purchase products.

In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. Dr. Robbins also shares insights into next-generation compounds his lab is developing and hints at positive clinical trial results coming soon.

🌐Links in this video

APERS & TRIALS

Fisetin at the ITP

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

https://pmc.ncbi.nlm.nih.gov/articles/PMC10828146/

Bone strength trial

Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans

https://clinicaltrials.gov/study/NCT04313634

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (SToMP-AD)

https://www.clinicaltrials.gov/study/NCT04685590

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00046-4/fulltext

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

https://pmc.ncbi.nlm.nih.gov/articles/PMC9924942/

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DESCRIPTION

Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.

Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.

🌐Links in this video

Dr Jeffery's page at UCL https://profiles.ucl.ac.uk/7465-glen-jeffery

Links to the NASA Study and write up

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

https://www.cell.com/cell/fulltext/S0092-8674(20)31461-6

https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/

Some papers mentioned in the inteview

Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision

https://www.nature.com/articles/s41598-025-09785-3

Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression

https://www.nature.com/articles/s41598-025-89081-2

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Discover why muscle power—not just strength—is the key predictor of healthy aging and longevity. Exercise physiologist Dr. Stuart Phillips reveals groundbreaking research showing that older adults can safely engage in power training, challenging decades of conventional wisdom about senior fitness.

In this interview renowned exercise physiologist and gerontology expert Dr. Stuart Phillips from McMaster University shares cutting-edge insights into optimizing exercise and nutrition for healthy aging. Dr. Phillips, who has spent decades researching muscle physiology and aging, breaks down the science behind successful aging and reveals why most people are focusing on the wrong metrics.

🌐Links in this video

Twitter/X: @McKinProf

Instagram: @McKinProf

LinkedIn: Stuart Phillips, McMaster University

TikTok: @McKinProf

Dr Phillips page at McMaster https://experts.mcmaster.ca/display/phillis

Dr Phillips' course on Coursera https://www.coursera.org/learn/hacking-exercise-health

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

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Revolutionary brain health breakthrough: Light therapy helmet shows remarkable results for memory loss and cognitive enhancement. Real patient stories reveal dramatic improvements in speech, balance, and memory function using photobiomodulation technology.

n this comprehensive interview with Liam, co-founder of Neuronic, we explore the cutting-edge world of photobiomodulation therapy for brain health. Discover how their light therapy devices - resembling bike helmets with 300+ LEDs - are helping patients with Alzheimer's, stroke, concussion, and long COVID brain fog. Liam shares incredible patient testimonials, including families saying "I got my mother back" and "I got my dad back" after just weeks of treatment. We dive deep into the science behind 1070 nanometer light therapy, discuss ongoing clinical trials, the FDA approval process, and how this technology is being used in clinics worldwide. Whether you're dealing with cognitive decline, seeking peak performance, or interested in preventive brain health, this episode reveals how light therapy could be a game-changer for neurological wellness.

🌐Links in this video

https://www.neuronic.online/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Discover why the standard B12 test might be missing your deficiency, and learn the better biomarkers that could reveal if brain fog, fatigue, and cognitive decline are actually nutrition-related rather than age-related.

In this deep dive with Dr. Martin Warren, Chief Scientific Officer at the Quadrum Institute and leading B12 researcher, we explore why vitamin B12 deficiency is far more common and complex than most people realize. Dr. Warren explains why standard B12 blood tests are unreliable (with only 50/50 accuracy for detecting deficiency), why the current deficiency cutoff of 148 picomolar may be too low, and how homocysteine and methylmalonic acid are better indicators of functional B12 status. He reveals that B12 deficiency can masquerade as normal aging—causing brain fog, fatigue, and cognitive decline—but is often reversible with proper treatment. The discussion covers why plant-based diets create deficiency risks, how absorption changes with age due to intrinsic factor decline, the connection between B12 and brain health (including white matter damage), and practical testing and supplementation strategies. Dr. Warren also makes a compelling case for revolutionizing healthcare through regular micronutrient monitoring rather than waiting for disease symptoms to appear.

🌐Links in this video

Quadram Institute. https://quadram.ac.uk/people/martin-warren/

Pernicious anemia society https://pernicious-anaemia-society.org/

Club 12 https://www.club-12.org/

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults https://pubmed.ncbi.nlm.nih.gov/39927551/

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https://www.choosemuse.com

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Nathan Bryan, the world's leading nitric oxide researcher, reveals how this simple molecule could be the key to preventing and reversing Alzheimer's disease, heart disease, and diabetes. He explains why nitric oxide drops by 80% after age 60 and shares practical solutions including his revolutionary lozenge technology.

In this comprehensive interview, Dr. Nathan Bryan, founder of Bryan Therapeutics and author of "The Secret of Nitric Oxide," breaks down decades of groundbreaking research on nitric oxide's role in human health. Dr. Bryan explains how nitric oxide functions as both a vasodilator and hormone, controlling blood flow, immune function, stem cell mobilization, and cellular energy production.

Key topics covered include:

Why nitric oxide production declines dramatically with age (down to 20% by age 60)

The two pathways your body uses to produce nitric oxide and what disrupts them

How mouthwash, antacids, and poor diet destroy nitric oxide production

The connection between nitric oxide deficiency and Alzheimer's, heart disease, and diabetes

Dr. Bryan's innovative lozenge technology that produces nitric oxide directly in the mouth

Practical lifestyle strategies: intermittent fasting, avoiding sugar, tongue scraping, and dietary choices

Future drug therapies in development for Alzheimer's, heart disease, and wound healing

Dr. Bryan presents compelling evidence that nitric oxide deficiency is the root cause of most age-related diseases and offers hope for prevention and reversal through targeted supplementation and lifestyle modifications.

🌐Links in this video

The Secret of Nitric Oxide-Bringing The Science To Life on Amazon https://amzn.to/3GHvXvq Dr Nathan's YouTube channel : https://www.youtube.com/@DrNathanSBryanNitricOxide Instagram https://www.instagram.com/drnathansbryan Twitter https://x.com/DrNitric

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Revolutionary brain health breakthrough: Light therapy helmet shows remarkable results for memory loss and cognitive enhancement. Real patient stories reveal dramatic improvements in speech, balance, and memory function using photobiomodulation technology.

In this comprehensive interview with Liam, co-founder of Neuronic, we explore the cutting-edge world of photobiomodulation therapy for brain health. Discover how their light therapy devices - resembling bike helmets with 300+ LEDs - are helping patients with Alzheimer's, stroke, concussion, and long COVID brain fog. Liam shares incredible patient testimonials, including families saying "I got my mother back" and "I got my dad back" after just weeks of treatment. We dive deep into the science behind 1070 nanometer light therapy, discuss ongoing clinical trials, the FDA approval process, and how this technology is being used in clinics worldwide. Whether you're dealing with cognitive decline, seeking peak performance, or interested in preventive brain health, this episode reveals how light therapy could be a game-changer for neurological wellness.

🌐Links in this video

Longevity.Technology web https://longevity.technology/

Healthspan XPrize https://www.xprize.org/prizes/healthspan

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https://www.choosemuse.com

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Vitamin A is essential for brain health, but are you getting the right amount? In this interview with Dr. Peter McCaffery (University of Aberdeen), we explore vitamin A’s critical role in memory, Alzheimer’s risk, and why blood tests fail to detect deficiency or toxicity. Learn how to optimize your levels—without risking overconsumption from liver or supplements.

🌐Links in this video

https://www.abdn.ac.uk/people/peter.mccaffery

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this eye-opening interview, board-certified psychiatrist and nutritional psychiatry expert Dr. Drew Ramsey reveals the 9 essential tenets of mental fitness from his new book, Healing the Modern Brain. Learn how to optimize your brain health, prevent dementia, and build resilience with actionable habits backed by neuroscience—from nutrition and sleep hacks to combating isolation and trauma.

🌐Links in this video

Dr Ramsey's website https://drewramseymd.com/

Healing the Modern Brain: Nine Tenets to Build Mental Fitness and Revitalize Your Mind https://amzn.to/4etNm7l

Eat to Beat Depression and Anxiety: Nourish Your Way to Better Mental Health in Six Weeks https://amzn.to/44inHtC

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan