Modern Healthspan

Dr. Allen Taylor spent 40 years at Tufts discovering how diet affects vision. Learn why high glycemic foods accelerate macular degeneration and cataracts—and what you can do to protect your eyes.

Dr. Allen Taylor directed the Laboratory for Nutrition and Vision Research at Tufts University for four decades, pioneering groundbreaking discoveries about how nutrition impacts age-related eye diseases. In this comprehensive interview, he reveals how high glycemic diets create a "double jeopardy" in your eyes—damaging proteins while simultaneously destroying your cellular cleanup systems.

Dr. Taylor explains the cellular mechanisms behind age-related macular degeneration (AMD) and cataracts, breaking down complex biochemistry into actionable insights. You'll learn about the epidemiological evidence linking Western diets to AMD risk, why blood sugar spikes matter even for non-diabetics, and how advanced glycation end products (AGEs) accumulate in retinal tissue.

The conversation covers practical strategies including which antioxidants matter most (vitamin C, vitamin E, lutein), why omega-3 fatty acids support retinal health, and how switching from high to low glycemic foods could prevent 100,000 cases of blinding AMD annually. Dr. Taylor also discusses his current intervention trial testing whether people with early AMD can preserve vision through dietary changes.

Key topics: macular degeneration, cataracts, glycemic index, nutrition and vision, eye health, aging, preventive medicine, antioxidants, drusen, photoreceptor health, retinal pigment epithelium, and practical dietary interventions for longevity

🌐Links in this video

Dr Taylor's page at Tufts https://facultyprofiles.tufts.edu/allen-taylor The review mentioned by Dr Taylor: Glycative stress as a cause of macular degeneration Full Version: https://tinyurl.com/bdp3u93f Summary Version: https://tinyurl.com/yj2zmx5n

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Your ferritin test doesn't measure what you think. Dr. Douglas Kell explains iron dysregulation, dormant microbes, and his controversial theory about chronic disease

Dr. Douglas Kell, systems biologist at the University of Liverpool, presents his research on iron dysregulation and its potential role in chronic inflammatory diseases. In this conversation, he explains why ferritin in blood is actually a marker of cell death rather than iron storage, how free iron can trigger oxidative stress through the Fenton reaction, and his hypothesis about dormant bacteria and amyloidogenic microclots. We discuss practical interventions including what iron tests actually matter (transferrin saturation over ferritin), natural compounds like ergothioneine from mushrooms that showed dramatic protective effects in studies, and enzymes like nattokinase that may help address abnormal clotting. Dr. Kell also covers his work on pre-eclampsia, the connection between iron and neurodegenerative diseases, and why he views most chronic inflammatory diseases through a systems biology lens. While his full IDDM (Iron Dysregulation and Dormant Microbes) hypothesis remains contested, the practical information on iron management and oxidative stress provides actionable insights for healthy aging.

🌐Links in this video

Dr Kell's page at University of Liverpool https://www.liverpool.ac.uk/people/douglas-kell DBK Group's web page with all Dr Kell's publications https://dbkgroup.org/

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Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up.

Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. His most intriguing finding? Ketones may allow us to "mimic a starvation environment when we're not starving" - potentially triggering the same hormetic benefits as fasting without dietary restriction. In this conversation, we explore the anti-inflammatory effects of ketones, the promising research in liver health and cancer, and the practical differences between ketone salts, esters, and MCT oil. Dr. Plaisance shares his personal ketone protocol (including why he takes them before workouts during time-restricted eating), optimal dosing strategies, and why the athletic performance marketing claims don't match the research. We also discuss who should actually consider ketone supplementation versus who should save their money. A grounded, evidence-based perspective on one of longevity's most debated supplements.

🌐Links in this video

Dr Plaisance's page at Alabama University https://scholars.uab.edu/2392-eric-plaisance

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Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones.

Dr. Mary Newport, physician and Alzheimer's researcher, joins us to discuss her latest research that challenges decades of assumptions about coconut oil and saturated fat. In this interview, we explore: • Her comprehensive analysis of 26 studies spanning 40 years (984 lipid profiles) showing coconut oil's unexpected effects on cholesterol • The 288 caregiver reports documenting improvements in memory, cognition, and daily function • How medium-chain triglycerides (MCTs) may provide an alternative fuel source for aging brains • Practical protocols for incorporating coconut oil and MCT oil into your diet • The controversial history of dietary fat guidelines and the trans fat problem • Why the medical establishment has been slow to acknowledge ketone research Dr. Newport's work began with her husband Steve's dramatic response to coconut oil after his early-onset Alzheimer's diagnosis. Her research has since expanded to include hundreds of case reports and comprehensive lipid analysis.

🌐Links in this video

🔗 Dr. Newport's website: https://coconutketones.com/ Coalition for Metabolic Health https://coalitionformetabolichealth.org/ Analysis of 26 Studies of the Impact of Coconut Oil on Lipid Parameters: Beyond Total and LDL Cholesterol https://www.mdpi.com/2072-6643/17/3/514 Ketogenic strategies for Alzheimer’s disease and other memory impairments: History, rationale, and 288 caregiver case reports https://esmed.org/MRA/mra/article/view/5316

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DESCRIPTION

Leading hairrestoration surgeon Dr. Alan Bauman reveals the science behind hair loss,graying, and the evidence-based treatments that actually work—from medicationsto regenerative therapies.

Dr. Alan Baumanis a board-certified hair restoration physician who has treated over 30,000patients and performed 14,000+ hair transplants in his 28-year career. In thisconversation, we explore the biological mechanisms behind hair loss andgraying, why you can lose 50% of your hair density before noticing it, and thepractical interventions that work.

We discuss theevidence for medications like minoxidil and finasteride, regenerative therapiesincluding PRP and exosomes, low-level laser therapy, and the role of lifestylefactors like nutrition, stress, and sleep. Dr. Bauman explains genetic testingfor hair loss predisposition, the truth about DHT-blocking shampoos, whetherhair coloring damages follicles, and when to consider surgical options.

Key takeaway:"Time equals follicles"—early intervention is critical because oncehair follicles are damaged, reversal becomes increasingly difficult. Whetheryou're experiencing thinning or want to protect your hair long-term, thisepisode provides actionable, science-based strategies.

🌐Links in this video

Bauman Medical website https://www.baumanmedical.com/

LinkedIn https://www.linkedin.com/in/alanjbauman/

Instagram https://www.instagram.com/baumanmedical/

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Dr. Henry Mahncke reveals how an NIH-funded study showed brain training reversed brain aging markers by 10 years, why speed-based training is uniquely effective, and the future of brain health interventions.

Dr. Henry Mahncke, CEO of Posit Science and creator of BrainHQ, discusses the groundbreaking INHANCE study that used PET scans to show brain training can reverse brain aging by 10 years. In this wide-ranging conversation, Dr. Mahncke explains how their adaptive brain training exercises increase acetylcholine—a crucial neurochemical that declines with age and is depleted in Alzheimer's disease. He addresses common criticisms of brain training, explaining why speed and accuracy training is fundamentally different from memorization exercises, and shares surprising insights including why Tom Brady uses brain training. We discuss optimal dosing (30 minutes daily works well), the role of sleep in brain plasticity, supplementation with compounds like phosphatidylcholine, and whether this should be a lifelong practice. Dr. Mahncke makes the case that we're at the beginning of a "brain health revolution" where maintaining cognitive function should be as routine as physical exercise

🌐Links in this video

Brain HQ website https://www.brainhq.com/ The trial on clinical trials https://clinicaltrials.gov/study/NCT04149457 Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial https://games.jmir.org/2025/1/e75161

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Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory.

Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he's turned his attention to longevity, and he's not just theorizing. Dr. Cramer is participating in Mitrix's groundbreaking mitochondrial transplantation trial, which aims to replace damaged mitochondrial DNA with healthy versions grown in bioreactors.

In this conversation, Dr. Cramer explains why he believes mitochondrial dysfunction is the root cause of aging, not just another hallmark. He discusses how energy depletion cascades into all other aging symptoms, why previous interventions like telomere extension haven't delivered, and what markers will be tracked throughout his trial. He also shares his personal longevity protocol, including rapamycin, senolytics, and hyperbaric oxygen therapy.

This is one of the first detailed discussions of autologous mitochondrial transplantation for aging in humans.

🌐Links in this video

Mitrix Bio website https://mitrix.bio

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

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Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.

Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.

The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.

Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.

This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.

🌐Links in this video

Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/38956196/

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Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.

In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.

Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.

He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.

🌐Links in this video

Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner

X (Twitter) https://x.com/CharlesMBrenner/

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Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.

In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.

We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.

🌐Links in this video

Dr Meikle's page at Baker https://baker.edu.au/research/staff/peter-meikle

Pelagic AI https://pelagicai.it/

Juvanescence https://juvlabs.com

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