Methylene blue was the first synthetic medicine ever created. 140 years later, we're discovering it might be one of the most powerful tools for brain health and longevity. Here's what the research actually shows.

Dr. Francisco Gonzalez-Lima has spent decades researching methylene blue, the first synthetic medicine in history. In this conversation, he explains how this unique compound enhances mitochondrial function, increases cellular energy production, and reduces oxidative stress; all at very low doses.

We discuss the critical importance of dose (low dose benefits, high dose harms), why pharmaceutical-grade purity matters, and how to personalize your dosing using a simple urine test. Dr. Gonzalez-Lima also addresses common misconceptions from failed Alzheimer's trials and explains why those studies used the wrong approach.

Looking ahead, he shares his plans to combine methylene blue with near-infrared light therapy and MCT oil for his upcoming clinical trial on mild cognitive impairment. Whether you're interested in cognitive enhancement, neuroprotection, or healthy aging, this is essential viewing.

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Dr Gonzalez-Lima's page https://liberalarts.utexas.edu/psychology/faculty/fg

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Hearing loss isn't just about your ears—it's about your brain. Dr. Ben Thompson reveals how treating hearing loss can reduce cognitive decline by 48% and shares breakthrough protocols for tinnitus recovery that actually work.

Audiologist Dr. Ben Thompson explains the critical connection between hearing health and cognitive function, discussing the landmark ACHIEVE study that showed hearing treatment reduced cognitive decline by 48% in at-risk older adults.

Learn how the ear and brain work together, what causes age-related hearing loss, and why the cochlea's hair cells don't regenerate. Dr. Thompson covers the biggest threats to your hearing (hint: it's not just aging), how to protect yourself from noise damage, and the truth about tinnitus, including why most people are told there's nothing they can do when effective treatments exist.

Discover how modern hearing aid technology has evolved beyond bulky devices to sleek, smartphone-integrated systems that actively separate speech from background noise. Whether you're experiencing hearing changes yourself or have aging family members, this conversation offers practical insights on preserving both hearing and cognitive health for the long term.

🌐Links in this video

Treble Health web page: https://treblehealth.com/

Treble Health YouTube Channel https://www.youtube.com/@treblehealth

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial

https://pubmed.ncbi.nlm.nih.gov/37478886/

The ACHIEVE study page https://www.achievestudy.org/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

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NAD+ Anti-Aging Breakthrough: How This Molecule Could Reverse Aging and Treat Alzheimer's Disease | Clinical Trial Results from Leading Longevity Researcher Dr. Evandro Fang

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Dr. Evandro Fang from the University of Oslo reveals groundbreaking research on NAD+ and its role in combating aging and neurodegenerative diseases. In this interview, Dr. Fang discusses his lab's pioneering work on mitophagy (mitochondrial cleanup) and how NAD+ precursors like NR and NMN have shown remarkable results in clinical trials for premature aging disorders. He shares dramatic case studies, including a 3-year-old Austrian boy who regained motor skills after NAD+ treatment, and explains the molecular mechanisms behind aging at the cellular level. The conversation covers his upcoming Phase 2 clinical trial using Urolithin A for Alzheimer's disease, the challenges of translating longevity research into approved therapies, and combination approaches involving exercise and caloric restriction. Dr. Fang provides practical insights into current NAD+ supplementation evidence while addressing safety concerns and optimal dosing strategies. This technical but accessible discussion offers valuable perspectives on the future of anti-aging medicine and therapeutic interventions for age-related diseases.

🌐Links in this video

Dr Fang's page https://evandrofanglab.com/

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Could a simple supplement that bodybuilders use to build muscle actually help fight Alzheimer's disease? Dr. Matthew Taylor from the University of Kansas reveals surprising results from her groundbreaking clinical trial testing high-dose creatine in Alzheimer's patients

In this episode, Dr. Matthew Taylor discusses his pioneering research on creatine supplementation for Alzheimer's disease, addressing a critical gap in brain energy metabolism that worsens with aging and becomes severely impaired in dementia. His 8-week clinical trial gave 20 Alzheimer's patients 20 grams of creatine daily - a bodybuilder's loading dose - and found remarkable improvements in memory, executive function, and even unexpected gains in reading comprehension. Using advanced MRI spectroscopy, his team confirmed that creatine actually reaches the brain, increasing levels by 11%. Beyond cognitive benefits, participants also showed significant improvements in hand grip strength and muscle mass. Dr. Taylor explains how brain energy metabolism creates a vicious cycle in Alzheimer's, explores whether creatine could prevent dementia in healthy aging, and reveals his plans for combining creatine with ketogenic diet approaches. This conversation offers hope for a simple, accessible intervention that could help millions facing cognitive decline.

🌐Links in this video

Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition

https://pmc.ncbi.nlm.nih.gov/articles/PMC12089086/

Dr Taylor's website at Kansas University https://www.kumc.edu/mtaylor3.html

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A potential functional cure for HIV could be just months away from human trials. Dr. Lanna reveals how her company Sentcell is using cellular rejuvenation to eliminate HIV reservoirs—and the surprising anti-aging benefits that come with it.

n this groundbreaking interview, Dr. Lanna, founder and CEO of Sentcell, explains how his team has developed a revolutionary approach to HIV treatment that could eliminate the need for lifelong antiretroviral therapy. Unlike traditional strategies that target the virus directly, Sentcell's method uses a molecule called DOS to rejuvenate CD4 T-cells, triggering them to naturally clear HIV DNA from their own genomes through a process that mimics elite controllers—rare individuals who can suppress HIV without medication. The treatment works by reactivating dormant cellular pathways that outcompete HIV's integration machinery, effectively reversing viral integration and clearing infected cells within days to weeks. Beyond HIV, Dr. Lanna discusses his team's discovery of "rivers of telomeres"—vesicle structures released by rejuvenated T-cells that can systemically rejuvenate other organs and extend lifespan by 12-17 months in animal studies. With Phase 1 human trials planned for 2026 at University College London, this research represents a potential paradigm shift from managing HIV as a chronic condition to achieving a functional cure.

🌐Links in this video

Sentcell website https://sentcell.life/

Dr Lanna on LinkedIn https://www.linkedin.com/in/professor-alessio-lanna-ph-d-687a1bb1/

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When someone's LDL cholesterol hits 574 mg/dL, doctors typically expect the worst. But what if everything we think we know about cholesterol and heart disease risk is incomplete?

In this episode, I sit down with researchers Nick Norwitz, Adrian Soto-Mota, and Dave Feldman to discuss their groundbreaking study on lean mass hyperresponders - a rare population who develop extremely high LDL cholesterol on ketogenic diets despite being lean, fit, and metabolically healthy. Their recent paper "Plaque Begets Plaque, ApoB Does Not" challenges conventional wisdom by showing that in this unique population, neither LDL cholesterol nor ApoB levels predicted plaque progression over one year of follow-up. Instead, existing plaque was the strongest predictor of future plaque growth. We explore the proposed lipid energy model that may explain why some people's cholesterol skyrockets on keto, discuss the limitations and implications of their findings, and examine what this means for personalized cardiovascular risk assessment. This conversation touches on fundamental questions about causality in medicine, the importance of studying outlier populations, and why a one-size-fits-all approach to cholesterol management may be missing crucial nuances.

🌐Links in this video

Longitudinal Data From the KETO-CTA Study: Plaque Predicts Plaque, ApoB Does Not https://pubmed.ncbi.nlm.nih.gov/40192608/

Citizen Science Foundation https://citizensciencefoundation.org/

Nick's home page https://www.nicknorwitz.com/

On X

Nick Nowitz https://x.com/nicknorwitz

Dave Feldman https://x.com/realDaveFeldman

Adrian Soto-Mota https://x.com/AdrianSotoMota

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Senescent cells were supposed to be the "easy" target in aging research—clear them out and extend healthspan. But new research reveals the field is far more complex than anyone imagined, with major clinical trial setbacks forcing scientists to completely rethink their approach.

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In this conversation with Dr. Paul Robbins from the University of Minnesota, we explore the evolving world of senescent cell research and senolytics—drugs designed to clear "zombie" cells from our bodies. Dr. Robbins reveals how recent research shows senescence is far more complex than expected, with different types arising from different stresses. We discuss why Unity Biotech's trials failed, mixed results from fisetin studies, and surprising positive signals from Mayo Clinic trials in patients with high senescent cell burden. He explains why future treatments will require personalized cocktails of different senolytics, the potential of alternative approaches, and why he remains optimistic despite setbacks. Dr. Robbins also shares insights into next-generation compounds his lab is developing and hints at positive clinical trial results coming soon.

🌐Links in this video

APERS & TRIALS

Fisetin at the ITP

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

https://pmc.ncbi.nlm.nih.gov/articles/PMC10828146/

Bone strength trial

Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans

https://clinicaltrials.gov/study/NCT04313634

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (SToMP-AD)

https://www.clinicaltrials.gov/study/NCT04685590

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00046-4/fulltext

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

https://pmc.ncbi.nlm.nih.gov/articles/PMC9924942/

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DESCRIPTION

Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.

Neuroscience professor Dr. Glen Jeffery from UCL reveals how LED lighting's blue light spike damages mitochondria, accelerates aging, and contributes to diabetes - while explaining simple solutions using red light therapy and incandescent bulbs to protect your health.

🌐Links in this video

Dr Jeffery's page at UCL https://profiles.ucl.ac.uk/7465-glen-jeffery

Links to the NASA Study and write up

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

https://www.cell.com/cell/fulltext/S0092-8674(20)31461-6

https://www.nasa.gov/humans-in-space/mitochondrial-changes-key-to-health-problems-in-space/

Some papers mentioned in the inteview

Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision

https://www.nature.com/articles/s41598-025-09785-3

Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression

https://www.nature.com/articles/s41598-025-89081-2

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Discover why muscle power—not just strength—is the key predictor of healthy aging and longevity. Exercise physiologist Dr. Stuart Phillips reveals groundbreaking research showing that older adults can safely engage in power training, challenging decades of conventional wisdom about senior fitness.

In this interview renowned exercise physiologist and gerontology expert Dr. Stuart Phillips from McMaster University shares cutting-edge insights into optimizing exercise and nutrition for healthy aging. Dr. Phillips, who has spent decades researching muscle physiology and aging, breaks down the science behind successful aging and reveals why most people are focusing on the wrong metrics.

🌐Links in this video

Twitter/X: @McKinProf

Instagram: @McKinProf

LinkedIn: Stuart Phillips, McMaster University

TikTok: @McKinProf

Dr Phillips page at McMaster https://experts.mcmaster.ca/display/phillis

Dr Phillips' course on Coursera https://www.coursera.org/learn/hacking-exercise-health

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Revolutionary brain health breakthrough: Light therapy helmet shows remarkable results for memory loss and cognitive enhancement. Real patient stories reveal dramatic improvements in speech, balance, and memory function using photobiomodulation technology.

n this comprehensive interview with Liam, co-founder of Neuronic, we explore the cutting-edge world of photobiomodulation therapy for brain health. Discover how their light therapy devices - resembling bike helmets with 300+ LEDs - are helping patients with Alzheimer's, stroke, concussion, and long COVID brain fog. Liam shares incredible patient testimonials, including families saying "I got my mother back" and "I got my dad back" after just weeks of treatment. We dive deep into the science behind 1070 nanometer light therapy, discuss ongoing clinical trials, the FDA approval process, and how this technology is being used in clinics worldwide. Whether you're dealing with cognitive decline, seeking peak performance, or interested in preventive brain health, this episode reveals how light therapy could be a game-changer for neurological wellness.

🌐Links in this video

https://www.neuronic.online/

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