Podcast Notes Playlist: Latest Episodes

Podcast Notes Playlist: Latest Episodes

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Podcast Notes Playlist: Latest Episodes episodes

  • 109: Nobel Prize Winner Frank Wilczek: Fundamentals — What Are The 10 Keys To Reality?

    Frank Wilczek is a theoretical physicist, author, and intellectual adventurer. He has received many prizes for his work, including a Nobel Prize in Physics. Win a FREE copy of his newest book Fundamentals: enter this giveaway – https://kingsumo.com/g/n7xeaa/win-a-copy-of-frank-wilczeks-fundamentals-10-keys-to-reality Wilczek has made seminal contributions to fundamental particle physics, cosmology, and the physics of materials. His current research focus includes Axions, Anyons, and Time Crystals, concepts in physics which he invented –each of which has become a major focus of worldwide research. In recent years Frank has become fascinated with prospects for expanding perception through technology. He is developing hardware and software tools for this. He has authored several well-known books and writes a monthly “Wilczek’s Universe” feature for the Wall Street Journal.

    His latest book, “Fundamentals”, was released in January 2021. Buy it here: https://amzn.to/3q9HNAr Wilczek received a B.S. at the University of Chicago in 1970, and a Ph.D. in physics at Princeton University in 1974.

    Currently he is the Herman Feshbach professor of physics at MIT; Founding Director of the T. D. Lee Institute and Chief Scientist at Wilczek Quantum Center, Shanghai Jiao Tong University; Distinguished Professor at Arizona State University; and Professor at Stockholm University.

    https://www.frankawilczek.com/

    • 00:04:43 What’s a day in your life like?
    • 00:05:25 Having a grandchild 0
    • 0:08:12 How Frank got interested in machine learning and AI.
    • 00:11:07 What are your current thoughts are AI?
    • 00:21:20 What are the fundamentals?
    • 00:24:05 What motivates to begin a new project?
    • 00:27:25 About axions.
    • 00:30:47 Breaking symmetry or an expanded definition of it?
    • 00:37:54 What’s fundamental about the scales of the universe?
    • 00:40:16 Thoughts about a future envisioned in science fiction.
    • 00:42:58 What do you think is the most beautiful experiment?
    • 00:57;04 What is the case for the existence of God?
    • 00:24:05 Is complexity fundamental?
    • 01:17:09 Will we find that axions explain Dark Matter?
    • 01:20:10 Detecting quantum gravitational waves.
    • 01:31:56 Are there hints about a core theory of everything?
    • Watch my most popular videos:

      • Sheldon Glashow: https://youtu.be/a0_iaWgxQtA?sub_confirmation=1
      • Sir Roger Penrose, Nobel Prize winner: https://www.youtube.com/watch?v=AMuqyAvX7Wo?sub_confirmation=1 Frank Wilczek https://youtu.be/3z8RqKMQHe0?sub_confirmation=1
      • Jill Tarter https://youtu.be/O9K9OBd3vHk?sub_confirmation=1
      • Eric Weinstein: https://youtu.be/YjsPb3kBGnk?sub_confirmation=1
      • Sir Roger Penrose https://youtu.be/H8G5onAqlVo?sub_confirmation=1
      • Juan Maldacena’s First Podcast Interview: https://youtu.be/uIzTliTHn7s?sub_confirmation=1
      • Jim Simons: https://youtu.be/6fr8XOtbPqM?sub_confirmation=1
      • Sara Seager Venus LIfe: https://youtu.be/QPsEDoOTU6k?sub_confirmation=1
      • Noam Chomsky: https://youtu.be/Iaz6JIxDh6Y?sub_confirmation=1
      • Sabine Hossenfelder: https://youtu.be/V6dMM2-X6nk?sub_confirmation=1
      • Sarah Scoles: https://youtu.be/apVKobWigMw
      • Stephen Wolfram: https://youtu.be/nSAemRxzmXM
      • 1 hr 14 min
      • Healthy Eating & Fitness For Kids, How Unschooling Works, Top Book Recommendations, Common Kitchen Mistakes & Much More: Ben Greenfield Puts His Sons In The Hot-Seat (The Official River & Terran Greenfield Interview).
        Ben Greenfield Fitness


        Podcast Notes Key Takeaways
        • There is evidence that humans are dreaming less often less vividly and experiencing less neuronal growth during sleep 
          • This is correlated with increased amounts of screen time leading to the hypothesis that whatever you watch on screens is accepted as your own thought processes and so your thinking is done for you 
        • Five core life skills according to Naval:
          • Reading
          • Writing
          • Talking
          • Arithmetic
          • Logic
        • The standardized method of education we use worked well during the Industrial Era, but we live in a completely different society now and education should change to reflect what is needed today
        • Ben encourages exercise by natural, animal-like movement 
          • A criticism of just working out at the gym is that it only makes you effective at certain mechanical motions and doesn’t translate into real-world fitness or even longevity
        • “I think that having that single, succinct purpose statement for your life is actually something that is important because that’s what gets you out of bed in the morning, right? In Japan, they call it ikigai. In Sardinia, they call it the plan de vida, like the plan for your life, this idea that when you wake up in the morning, you know what it is that you’re going to do with the life that God has given you.” – Ben Greenfield
        • “A man is free to choose his attitude no matter what circumstances he is given in life”
          • Many people have wasted their lockdowns binging Netflix or mindlessly scrolling social media while others have pursued productive endeavors 


        Read the full notes @ podcastnotes.org



        River and Terran Greenfield are my twin 12 year old sons. They are unschooled, they are hyper-creative, they can survive in the wilderness with a knife, backpack and wool blanket, they know more kitchen and cooking tricks than most adults (and have an amazing cooking podcast), and they are generally crushing life.

        So in this very special episode, I put my twin boys in the podcasting hot seat to discuss life, creativity, cooking and healthy eating for kids, fitness, and much more.

        During our discussion, you'll discover: -Best breakfast to crush the day.. 4:40
        • Fresh-baked sourdough bread w/ jam and butter
        • Eggs and bacon
        • Smoothies made w/ Organifi
        • Florida Cells French restaurant in N. Idaho
        -How to tell River and Terran apart, especially on audio...6:50 -Books River and Terran like to read.. 8:15
        • Graphic novels (novel illustrated in comic book style)
          • Wings of Fire
          • Asterisk
          • Graveyard by Neil Gaiman
        • The Hero's Journey by
        • The Writer's Journey by Christopher Vogler
        • Graphic novels always contain a distinct style in the artwork
        • The Lost Language of Plants (television destroyed dreaming)
        • Almanac of Naval Ravikant
        -Unschooling and becoming self-directed learners.. 19:04
        • Essay by Naval Ravikant Ben mentions on the 5 core skills needed for life
          • Reading
          • Writing (long form)
          • Logic and/or computer programming
          • Arithmetic
          • Rhetoric/persuasion
        • The Almanac of Charlie Munger
        • Mathnasium program River and Terran use for their schooling
        • Unschooling allows learning how the world works alongside the subjects being learned (math, logic, etc.)
        • Advantages of AI and robots outweigh the negatives (skills becoming obsolete)
        • Rhetoric game
        • Tell 'em what you're gonna tell 'em; then tell 'em; then tell 'em what you told 'em
        -A typical evening in the Greenfield home.. 35:00
        • Board/card games
          • Quibbler
          • Web of Spies
          • Telestrations
          • Boggle
          • Scattergories
          • Scrabble
        • BGF podcast w/ James Altucher on game theory
        -An average day for River and Terran.. 37:35
        • Feed rabbits, play a game, play piano, workout, shoot bow
        • More scheduled or structured play/learning til 3-5 pm
        • Is life school, or is school life?
        • BGF podcast on unschooling
        • Journal on daily activities
        • St. Andrews College in Moscow, ID
        • Liberal arts studies is a good way to get a well-rounded education
        -Favorites things River and Terran do for their fitness.. 44:30
        • Make up own workouts; workouts w/ dad give more motivation
        • Animal Movements by Darrell Edwards
        • Irwin Lecour movement fitness
        • Sandbags, kettlebells
        • Exercise is more than workouts, gyms; movement throughout the day
        • Breathwork:
          • 4 in, 8 out promotes parasympathetic nervous system
          • SOMA breathwork course
          • BGF article on the SOMA course
          • Far better for stress control than pill popping
        • BGF podcast w/ Niraj Naik, the Renegade Pharmacist
        • Fish oil supplement
        • Restore for gut health
        • Glutathione supplement
        • Limit screen time
        -River and Terran's diet tips.. 50:45
        • Breakfast: natural eggs and meat
        • Lunch: Sandwiches w/ mom's sourdough bread
        • Wild Planet fish
        • Pickles, lettuce, arugula in the sandwiches
        • Walnuts, raisins for snacks
        • Sesame seed rice crackers
        • Sparkling water
        • Halo stevia drink
        • Mocktails at restaurants
        • Izzy for parties
        • Chai tea and Italian sodas
        • Coconut ice cream for dessert
        -Is there a perfect diet all humans should follow?.. 54:40
        • Mediterranean diet seems more agreeable than other diets
        • Eating w/ people, long family dinners
        • Making your own food helps you appreciate it more
        • Easy to overeat from packages vs. food prepared yourself
        -River and Terran's views on screen time and video games...57:00
        • They both have an iPod Touch and is for business purposes (podcast)
        • Computer used mostly for school
        -About the Go Greenfields cooking podcast.. 59:15
        • Started 4+ years ago
        • Began learning to cook at age of 3 (made mom eggs for Mothers Day)
        • The Four Hour Chef by Tim Ferris
        • Eggs are a great starting point for learning to cook
        • Favorite recipes:
          • Paleo doughnuts made w/ Magic Spoon cereal
          • Terran: Soufflé
          • River: Risotto
        • Top baking tip from Terran: Don't overcook; don't rely on looks to determine if it's done
        • Top risotto tip from River: Keep stirring, pay attention constantly
        • Top tip from the chef: Don't add too many seasonings; keep it simple
        • Clean up as you go
        • Pay attention to recipes
        -Tips on hunting and plant foraging.. 1:09:30
        • Do it a lot at home to appreciate the diversity in other locales
        • Bow hunting is more natural and dependent on physicality than w/ a rifle
        -How to care for yourself spiritually.. 1:12:45
        • First thing in the day: read Bible, journal, express gratitude
        • Sing doxology every Sunday
        • Spiritual Disciplines handbook by Adele Calhoun
        • Abide app
        • Self-examination at the end of each day allows you to reflect on how you did that day
        -River and Terran's own life purposes.. 1:15:30
        • "To make the love and joy of God through writing and art"
        • "To use my art to make people feel strong emotions"
        -River and Terran's take on 2020 w/ COVID-19, lockdowns, masks, etc.. 1:16:35
        • They enjoy seeing dad more
        • Different reactions w/ kids vs. adults
        -One thing River and Terran think everyone should know or experience.. 1:19:40 -And much more! Resources from this episode:

        -The GoGreenfields podcast

        Episode sponsors:

        -The Kion Fasting Challenge: The Challenge starts January 6th, it's completely FREE to join, and when you do you'll get a bunch of exclusive content including access to a Q&A by yours truly answering all your burning fasting questions. To join just go to getkion.com/fasting-ben

        -Organifi Green Juice: Now you can get all your healthy superfoods in one glass...with No Shopping, No Blending, No Juicing, and No Cleanup. Get a 20% discount on your entire order when you use discount code: BENG20

        -Lucy Nicotine Gum: If you are looking for a cleaner and tastier alternative to other nicotine products, then this product is for you. The gum comes in three flavors - Wintergreen, Cinnamon, and Pomegranate - and the lozenges in cherry ice. To save 20% on any order, just use discount code: BEN 20.

        -Water and Wellness: The best solution for clean and safe drinking water. Water and Wellness also offers an amazing line of essential water additives such as Quinton Marine plasma which contain over 78 trace minerals and elements from the ocean to help restore your biological-terrain. Get 15% off your order when you use discount code: GREENFIELD

        Do you have questions, thoughts or feedback for River Greenfield, Terran Greenfield or me? Leave your comments at bengreenfieldfitness.com/gogreenfields and one of us will reply!
        1 hr 24 min
      • 1465: The Truth About Health at Every Size
        MInd Pump


        Podcast Notes Key Takeaways
        • Pop magazines shouldn’t be your source of health and wellness
        • The real “healthy at any size” movement has been highjacked
        • Don’t compare person to person: an overweight person is not less healthy than a lean bodybuilder who abuses steroids, extreme diets, and doesn’t sleep
        • We have normalized obesity in part because food is a more acceptable addiction than others
        • Objectively, your health will improve if you are within a healthy range of body fat
        • Don’t equate love with simply not hating yourself


        Read the full notes @ podcastnotes.org



        In this episode Sal, Adam & Justin discuss recent Cosmopolitan covers and the health at every size movement.

        • Why Cosmopolitan isn’t the place to go for health information. (3:34)
        • What the “health at every size” ACTUALLY means. (8:20)
        • The history surrounding obesity and how there is a wide range of body types. (12:31)
        • Why being “healthy” encompasses A LOT of things. (19:10)
        • What loving yourself really means. (27:17)

        Related Links/Products Mentioned

        • December Special (Extended until Jan. 10th, 2021): 3 MAPS Bundles for your level of fitness!
        • Visit Legion Athletics for the exclusive offer for Mind Pump listeners! **Code “mindpump” at checkout**
        • Cosmopolitan Cover Promotes Plus Size Women as ‘Healthy’
        • @mindpumpsal post “Health at every size”
        • Health At Every Size Community Resources
        • Loneliness: A disease?
        • Workout Because You Love Yourself Not Because You Hate Yourself – Mind Pump Blog
        • Mind Pump Podcast – YouTube
        • Mind Pump Free Resources
        38 min
      • #152 – Dan Gable: Olympic Wrestling, Mental Toughness & the Making of Champions
        Dan Gable is one of the greatest Olympic athletes and wrestling coaches of all time. Please support this podcast by checking out our sponsors: – Tryolabs: https://tryolabs.com/lex – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free – Grammarly: https://grammarly.com/lex to get 20% off premium – SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera EPISODE LINKS: Dan’s Twitter: https://twitter.com/dannygable Dan’s Website: https://dangable.com/ Dan’s Books: https://amzn.to/2VK5nbn PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s
        1 hr 17 min
      • #491: Dr. Stefi Cohen — 25 World Records, Power Training, Deadlifting 4.4x Bodyweight, Sports Psychology, Overcoming Pain, and More
        Dr. Stefi Cohen — 25 World Records, Power Training, Deadlifting 4.4x Bodyweight, Sports Psychology, Overcoming Pain, and More | Brought to you by Tonal smart home gym, LMNT electrolyte supplement, and Athletic Greens all-in-one nutritional supplement
        "[Visualize] a negative outcome. We don’t want to plan for it, but we need to prepare for it so we know how to react. Can you keep it together and try again, or will you crumble under pressure?" — Dr. Stefi Cohen
        Stefi Cohen (@steficohen) is a 25x world-record-holding powerlifter and the first woman in the history of the sport to deadlift 4.4x her body weight. She is a doctor of physical therapy, author, co-host of the Hybrid Unlimited podcast, and business owner passionately educating people with her NO BS, evidence-based view on all things training and nutrition.
        Stefi is the co-owner of Hybrid Performance Method, where hundreds of thousands of strength seekers go monthly to find progressive strength training and nutrition programs plus tons of free articles and videos. Stefi is a creative mind and loves collaborating with the Hybrid team and partners to develop powerful content, inspired fashion, and both fitness and nutrition tools for a stronger life.
        Stefi is also the co-author (with Ian Kaplan) of Back in Motion, now available for pre-order.
        Please enjoy!
        *
        This episode is brought to you by Tonal! Tonal is the world's most intelligent home gym and personal trainer. It is precision engineered and designed to be the world’s most advanced strength studio. Tonal uses breakthrough technology—like adaptive digital weights and A.I. learning—together with the best experts in resistance training so you get stronger, faster. Every program is personalized to your body using A.I., and smart features check your form in real time, just like a personal trainer.
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        This episode is also brought to you by LMNT! What is LMNT? It’s a delicious, sugar-free electrolyte drink-mix. I’ve stocked up on boxes and boxes of this and usually use it 1–2 times per day. LMNT is formulated to help anyone with their electrolyte needs and perfectly suited to folks following a keto, low-carb, or Paleo diet. If you are on a low-carb diet or fasting, electrolytes play a key role in relieving hunger, cramps, headaches, tiredness, and dizziness.
        LMNT came up with a very special offer for you, my dear listeners. For a limited time, you can claim a free LMNT Sample Pack—you only cover the cost of shipping. For US customers, this means you can receive an 8-count sample pack for only $5. Simply go to DrinkLMNT.com/Tim to claim your free 8-count sample pack.
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        This episode is also brought to you by Athletic Greens. I get asked all the time, “If you could only use one supplement, what would it be?” My answer is usually Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. 
        Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.
        *
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        For show notes and past guests, please visit tim.blog/podcast.
        Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.
        For transcripts of episodes, go to tim.blog/transcripts.
        Discover Tim’s books: tim.blog/books.
        Follow Tim:
        Twitter: twitter.com/tferriss 
        Instagram: instagram.com/timferriss
        Facebook: facebook.com/timferriss 
        YouTube: youtube.com/timferriss
        2 hr 15 min
      • Wim Hof "The Iceman" Shares How to Change Your Biochemistry with Deep Breathing | Impact Theory
        Impact Theory with Tom Bilyeu


        Podcast Notes Key Takeaways
        • “We don’t know the power of our own breath and therefore we don’t know how to connect with our own biochemistry.” – Wim Hof
        • The cold teaches you how to deal with temperature and more importantly, how to deal with stress
        • Expose yourself to cold, learn to breathe, connect with nature, and tap into lizard brain
        • “In the cold water you don’t think. You go into the brain stem – you go into a non-thinking part of your brain because you have to survive at that moment.” – Wim Hof
        • We hold on through our thoughts: the cold allows us to reset and find the energy and purpose again


        Read the full notes @ podcastnotes.org



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        There is a hidden power within you, covered up and suppressed by our modern way of living and thinking. Through a disciplined practice of cold water therapy, breathing, and mind-body connection, you can awaken the lost powers of your DNA and enter into a place of healing not possible even through today’s modern medical practices. On this episode of Impact Theory, Tom Bilyeu is joined by Wim Hof, better known as ‘The Iceman,’ to discuss such matters and more as they explore how to unlock your brain, spirit, and body’s true potential by connecting to your ancestral DNA and uncovering the true depths of yourself. They discuss Wim’s early life and it’s influence on him towards finding his purpose, how to gain complete control over your body, why you should be seeking the light inside you, why respecting your ancestral history is important, how to enter into your own DNA and grasp your true purpose, how to think with intention, the power of seeking true freedom, why you have to learn to let go before all else, the scientific proof behind his methods, how his methods are leading to the curing of diseases and illnesses, and why there is a hidden healing power within you.

         

        SHOW NOTES:

         

        Mindset | Wim shares his personal story of his dramatic birth and entering the world. [0:14]

        Finding Purpose | Wim reveals how cold water practices became his purpose. [3:17]

        Being Different | Wim reveals why cold therapy leads to breakthroughs for humankind. [5:52]

        Complete Control | Wim reveals how he was able to control the vagus nerve. [10:39]

        The Light | Wim reveals why your purpose is the life that flows through you. [12:21]

        Ancestry | Wim reveals why you should have respect for your ancestry. [15:35]

        DNA | Wim reveals how to enter into your DNA and grasp the purpose of your being. [16:40]

        Go Inside | Wim reveals how to enter into the unlimited power of your own brain. [18:21]

        Intention | Wim reveals the power of thinking with intention on the body. [20:01]

        True Freedom | Wim reveals his journey of seeking true free thinking. [23:29]

        Letting Go | Wim reveals the benefits of letting go of what you ‘have to do.’ [25:16]

        Under a Spell | Wim reveals the dangerous spell most of the world falls under. [26:00]

        Seeing More | Wim discusses how he overcame in his wife’s suicide. [29:25]

        It Works | Wim reveals why his techniques work fast and effectively. [35:52]

        Breathing | Wim reveals the healing power of his breathing exercises. [37:45]

        Heat | Wim reveals how he was able to run a marathon in the desert without water. [42:59]

        Connect | Wim reveals how to stay connected and follow him for more. [47:11]

         

        QUOTES:

         

        “You said, “I’m doing right now, with top researchers, on DNA to show that we have the absolute influence neurologically at will to enter into our own ancestral encrypted codes of the DNA, our genetic past, to enlighten our past right here in the moment.”" [6:15]

         

        “So, if we go for the best within ourselves for a freedom, a fearless state of being, a very powerful being that is not being withheld by anything. If you like that, then you have to go and deal with the encrypted codes in the DNA and release it.” [16:07]

         

        “…I recommend this for everybody who suffers. From people who are suicidal or tragic deaths, go into the cold water. It makes your body able to reset, to find the energy, the purpose again.”[32:10]

         

        FOLLOW WIM:

        Website: wimhofmethod.com

        App: wimhofmethod.com/wim-hof-method-mobile-app

        Twitter: twitter.com/Iceman_Hof

        Facebook: facebook.com/icemanwimhof

        Instagram: instagram.com/iceman_hof

        YouTube: youtube.com/user/wimhof1

        58 min
      • Brian Roemmele – The Intelligence Amplifier (EP.29)
        Infinite Loops


        Podcast Notes Key Takeaways
        • Human senses take in about 100,000,000 bits of info per second but the human brain has a limit of 41 bits per second
        • Your inner editor helps you process input and removes things that it thinks are not important
        • The average person today takes in the same information in a day that a person living in the 1800s would take in in a year
        • Your inner voice remembers specific experiences and you make a connection with your personal contextual web – It amplifies your experiences
        • The Intelligence Amplifier concept says that people can sell access to themselves BUT only with security, permission, and control
        • “Realize that your time here is meant for you to figure out why you’re here and the only thing you leave behind is your love.” – Brian Roemmele


        Read the full notes @ podcastnotes.org



        In this episode of Infinite Loops we spoke with Brian Roemmele, aka “The Voice Expert”. Our long and in-depth conversation covers:

        • The rise of Voice systems like Alexa
        • The future of voice, AI, and knowledge
        • Brian’s exciting invention
        • Intelligence Amplification 
        • And MUCH more

        Follow Brian (https://twitter.com/BrianRoemmele) on Twitter, and check out his website  http://voicefirst.expert/.

        1 hr 43 min
      • #100 Matt Mullenweg: Collaboration Is Key
        Knowledge Project


        Podcast Notes Key Takeaways
        • “Open-source is a hack that gets competitors to work together” Matt Mullenweg 
          • Humans outcompeted all other animals because they could collaborate
          • That’s why in the long run, open-source software will win every market that’s in
        • With open-source software, you get the opposite of the tragedy of the commons
          • Each person working in his self-interest makes the thing better
        • Working together in person gets people closer, in a way that you can’t replicate online
          • Knowing that this is an issue you have to actively invest to improve relationships with co-workers
          • Automattic’s “Secret Sauce” is to get people to get together in-person 3-4 times annually
        • “Make reversible decisions quickly and irreversible ones deliberately” Tony Schneider (early business partner)
          • If it’s a reversible one you’ll learn a lot more by doing it, rather than debating it for weeks
        • Matt never wanted Automattic to take over the market for WordPress paid services
          • You have to capture enough, but always less than the value you create for others
        • “It’s very difficult to drive World-changing performance if it’s just for a paycheck, or just for your personal benefit, you need to be connected to something larger” Matt Mullenweg


        Read the full notes @ podcastnotes.org



        Matt Mullenweg is the co-founder of WordPress, the open platform that runs most of the sites you visit and the CEO of Automattic. In this episode Matt and Shane discuss distributed work, the 5 levels of autonomous organizations, decision making, running an organization with more than 1300 people, integrating acquisitions and so much more.

        Go Premium: Members get early access, ad-free episodes, hand-edited transcripts, searchable transcripts, member only episodes, and more. https://fs.blog/knowledge-project-premium/

        Stay up to date by singing up for Brain Food, our weekly newsletter that comes out each Sunday with timeless insights for life and business. Sign up here: https://fs.blog/newsletter/

        Follow Shane on twitter at: https://twitter.com/ShaneAParrish

        1 hr 26 min
      • Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
        Found My Fitness - Rhonda Patrick


        Podcast Notes Key Takeaways
        • The Horvath Aging Clock is collected through DNA sample and currently the most accurate estimate of chronological age
        • The epigenetic clock is under genetic control – evidence strongly suggests the epigenetic clock is a continuous readout that links prenatal tissue directly to disease and healthspan in older age
        • Some people inherit DNA which allows their epigenetic clock to progress slower
        • Early studies show DNA GrimAge is a good predictor of time to heart disease and chronic disease before clinical markers appear
        • Compared to the epigenetic clock, telomere length is a weak predictor of aging
        • In healthy people, even a “perfect” lifestyle won’t make a big dent in epigenetic age
        • The weakness of the epigenetic clocks is that we don’t understand the specific regulators of these clocks 


        Read the full notes @ podcastnotes.org



        Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

        In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging.

        Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath

        Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath

        Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath

        Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock

        The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks

        1 hr 34 min

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