Podcast Notes Playlist: Latest Episodes

John Collison and Dwarkesh Patel sit down with Elon Musk to discuss why the future of AI isn’t on Earth, but in the "always sunny" vacuum of space. Between pints, they discuss the brutal physics of scaling—from the "farcically cheap" solar cells coming out of China to switching Starship from carbon fiber to stainless steel—as well as the “infinite money glitch” of humanoid robots, China, and DOGE.

Timestamps

00:00:23 Space GPUs

00:35:39 Alignment

00:58:48 xAI

01:15:01 Optimus

01:28:03 China

01:40:46 Management

02:16:38 DOGE

02:34:58 Space GPUs redux

Remember when Facebook was fun and Google actually worked? Cory Doctorow coined a term for what went wrong, and he's here to explain how we fight back.

Full show notes and resources can be found here: jordanharbinger.com/1280

What We Discuss with Cory Doctorow:

• "Enshittification" is Cory Doctorow's term for how platforms decay. First they're good to users, then they abuse users to serve business customers, then they abuse everyone to claw back value for themselves. Facebook, Amazon, and Google all followed this playbook — and policy makers let it happen.
• "Switching costs" are a deliberate policy choice, not an inevitability. Companies jack up the friction of leaving their platforms through design and lobbying, but regulations like phone number portability prove we can legislate friction down when we choose to.
• The Digital Millennium Copyright Act criminalizes fixing things you own. Security researchers who expose corporate sabotage — like the Polish train company bricking locomotives to extort customers — face harsher legal consequences than actual pirates.
• "Algorithmic wage discrimination" is surveillance capitalism's newest trick. Apps like Uber track how desperate workers are and pay them less accordingly — the more rides you accept, the lower your future offers, turning desperation into a permanent wage ceiling.
• You can fight back by supporting interoperability and making strategic choices. Use alternative services (like Kagi for search), follow advocates like the Electronic Frontier Foundation (eff.org), and remember: every time you demand the right to own what you buy, you're pushing back against enshittification.
• And much more...

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This week, Jonathan Haidt, author of “The Anxious Generation,” returns to the show to discuss new research about how social media is harming teens and what it’s been like to become the face of a global movement against the platforms. Then, we asked what you were building with Claude Code, and you blew us away. We’ll share some of our favorite projects that you sent us. And finally, we’re joined by PJ Vogt, the host of “Search Engine,” to talk about our early adventures in the Forkiverse and what we’ve learned so far about running a social media network.

Guests:

• Jonathan Haidt, social psychologist and author of “The Anxious Generation"
• PJ Vogt, host of “Search Engine”

Additional Reading: 

• Mountains of Evidence 
• Meta’s Internal Research
• An NYT Event in LA - Trump: The First Year of His Second Term

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(0:00) Friedberg intros FDA Commissioner Marty Makary

(3:21) Inside the 42 major FDA reforms in 10 months

(7:51) The China Race: Winning back biotech leadership

(13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines

(33:13) Reshaping the failed Food Pyramid

(41:29) GLP-1s and America's Obesity Epidemic

(49:54) Rethinking vaccines from first principles

(59:40) Lowering drug prices, the power of AI for healthcare

(1:18:57) What causes autism?

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