Dr. Dale Bredesen discusses Alzheimer’s Disease Research Controversies with Dr. Ben Weitz.
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Podcast Highlights
0:35 Alzheimer’s disease is the most common form of dementia and it’s the most common neurodegenerative disease, and numbers are increasing. Conventional medical research has not produced any successful drugs or treatments. Last year a controversial drug–Aduhelm (aducanumab) was approved for the treatment of Alzheimer’s disease, but it actually failed 3 of the 4 clinical trials that were conducted and while it reduces amyloid plaques in the brain, patients with Alzheimer’s disease do not actually improve but only get worse at a slower pace. And 35% of patients get painful brain swelling and some also get bleeding in the brain.
1:45 On July 21st in Science, an article was published that blew the lid off of the Alzheimer’s disease research. It was revealed that images were likely falsified that were included in the landmark study published in 2006 by Dr. Sylvain Lesne, Karen Ashe, and others that was supposedly the first to proved that beta amyloid is actually the cause of Alzheimer’s disease. This study was referenced in over 2000 other studies and is the basis of hundreds of millions of dollars of NIH and drug company research. Therefore, this is perhaps the largest scandal in the medical research field and appears to me to call into question the 30-year-old beta amyloid Alzheimer’s disease hypothesis.
2:40 Another important paper, with Dr. Dale Bredesen as the senior author, was also published online in July in the Journal of Alzheimer’s Disease that demonstrates for the first time that a precision medicine approach, (a Functional Medicine approach) can actually reverse Alzheimer’s disease. [Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project. Toups, Kat et al.]
4:03 I asked Dr. Bredesen what the significance of this science article that alleges fraud that appears to have been committed by Dr. Lesne and possibly others? His answer is “The Titanic that is mainstream medicine is sinking right before all of our eyes, having crashed into the iceberg that is chronic illness and that is the problem.” Alzheimer’s Disease, like diabetes and lupus and heart disease and cancer, is a chronic disease that is not going to be properly addressed by simply prescribing a drug. Alzheimer’s disease researchers have developed many drugs to remove amyloid–bapineuzumab, solanezumab, gantenerumab, crenezumab, aducanumab, donanemab–but they don’t reverse the condition and at most slow down the progression a bit. While Western medicine can effectively treat many types of infections, it is not effective for complex chronic illnesses like Alzheimer’s disease.
6:27 Dr. Bredesen used the following analogy to explain why the reductionist approach of conventional medicine fails when dealing with complex, chronic diseases: “imagine that you took your jets from all the different jets that are flying, from all the different groups, from Delta, United, American and so forth and so on, and you took them in for servicing, but you said you can only limit it to one prescription. You give one thing, you can either fill it up with gas or you can fix the oil, or you can look at the engine, but you can only do one thing.