Welcome to another episode of Solving the Puzzle with Dr. Datis Kharrazian. Today’s conversation focused on the complexities of hormone imbalance and the various approaches to managing hormone-related health issues. A key theme that emerged was the distinction between a straightforward, hormone-replacement-only model and more nuanced, functional medicine approaches that consider underlying mechanisms behind endocrine disorders.

We explored the widespread use of hormones in managing conditions such as menstrual irregularities, perimenopause symptoms, and menopause, while raising important concerns about the risks and long-term consequences of these therapies, including weight gain, depression, cancer, hypertension, and stroke. 

To Register for Hormone Imbalances Throughout the Lifespan – Clinical Strategies and Treatment Applications, visit https://pages.kharrazianinstitute.com/hormone-imbalances

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

00:00 Balancing hormones and lifestyle approaches

05:41 Critique of hormone replacement therapy

09:21 Concerns about oral contraceptives

10:21 Oral contraceptives and cancer risks

13:51 Managing perimenopause symptoms

18:34 Menopause and hormone therapy discussion

22:45 Ending and Trial Offer Info

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In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.

We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

00:00 Factors affecting mitochondrial function

03:55 Optimizing patient bioenergetics basics

09:27 Mitochondria and cell evolution

12:33 Focus on acquired mitochondrial dysfunctions

14:23 Mitochondrial ATP production process

20:22 Ketogenic diet and energy pathways

21:15 Ketogenic diet for chronic fatigue

27:02 Exploring functional medicine resources

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Dr. Elding has been practicing chiropractic and functional medicine in Osseo, Wisconsin, a town of 3,500, for nearly four decades. In this conversation, he shares what it's really like to run a solo functional medicine practice in a rural, low-income community: no staff, no website, no nearby labs, and an entirely word-of-mouth practice. Dr. Elding talks about how he combines functional neurology exams with functional medicine labs to catch things conventional providers miss, the patient cases that stuck with him (including a 32-year-old who quit a $400k job to heal her celiac disease), and how his philosophy has shifted from heavy testing to deep listening over the years. He also opens up about recovering from a catastrophic cycling accident, his family health history, and why, after 39 years, he has no plans to retire. 

Dr. Steven Edling, DC, is a Chiropractor specialist practicing in Osceola, WI with 39 years of experience. 

0:00 – Intro & Dr. Elding's background: 39 years in small-town chiropractic and functional medicine

6:04 – Avoiding burnout; the importance of staying curious and constantly learning

14:50 – Real patient cases: where functional neurology meets functional medicine

21:00 – The $400K corporate burnout patient who quit her job to heal

28:13 – Adapting practice to a rural, low-income community

38:08 – Why the Kharrazian Institute changed his practice (and his life)

45:06 – Recovering from 42 fractures; why he'll never retire 

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case studies and practical strategies for supporting gut health, autoimmune recovery, muscle maintenance, and post-injury healing. Whether you're a healthcare practitioner, a certified nutritionist, or simply looking for ways to optimize your health, this episode bridges complex science with practical solutions you can implement today. 

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Benefits and side effects of oral bpc

04:37 Addressing complex digestive issues

08:35 Managing gut inflammation

11:53 Using Pepti Strong for healing

15:15 Discussing growth hormone peptides

17:55 Growth hormone and cognitive function

20:38 Recognizing and managing drug reactions

26:00 Using peptides for post-op recovery

29:11 Podcast outro and resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore personalized approaches from thought leaders like Amy Yasko, Ben Lynch, William Walsh, and Bob Miller, discussing practical protocols for methylation, balancing minerals, and managing inflammation. 

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Balancing neurochemicals in children

04:16 Starting folate and B12 supplementation

07:00 Discussing William Walsh's approach

10:41 Understanding methylfolate tolerance

15:31 Patients help promote our practice

18:54 Genetic mutations and food sensitivity

23:19 Learning about methylation pathways

23:58 Evaluating a child's diet and genes

29:56 Discussing toxic exposures and genetics

31:06 Podcast resources and final thoughts

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance.

Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions. 

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Identifying high hydrogen peroxide symptoms

03:06 Addressing brain fog and fatigue

08:11 Combating jet lag with supplements

12:01 Understanding hormone breakdown genetics

13:36 Finasteride side effects and solutions

19:18 Importance of Selenium and Zinc

21:10 Initial treatment and Dutch test results

25:50 Podcast resources and disclaimers

26:53 End of the episode reminder

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception.

We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Understanding types of pain

04:57 How mood affects pain perception

08:02 Why visceral pain feels external

12:04 How pain signals are amplified

15:58 How pain is blocked

19:44 How the brain processes pain

22:12 Understanding central pain syndromes

26:01 Explaining brain pathways for pain

30:06 Podcast outro and resources

31:09 Closing message and reminder

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps impacting mood, energy, and neurological health. Whether you're a practitioner seeking a sharper clinical eye or simply want to optimize your well-being, this episode supplies you with insights and tools to decode your body's signals and restore balance.

Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Signs of vitamin A deficiency

06:21 Vitamin E and K deficiencies

07:30 Fermented foods and vitamin K

10:48 Understanding methylation and B vitamins

16:42 Effects of vitamin B6 on sleep

18:25 Signs and symptoms of B12 deficiency

23:37 Identifying causes of muscle cramps

25:57 Recognizing magnesium deficiency signs

30:20 Signs of potassium and zinc issues

31:28 Wrapping up and resources offered

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from dryness and discoloration to eczema, rosacea, and more. Whether you're a practitioner or someone interested in optimizing your own health, this episode bridges complex science and practical tips you can apply today. 

Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Skin health and nutritional basics

03:56 Vitamin A and bruising

07:41 Eating healthy fats and fish

12:14 Identifying allergies and histamine response

15:07 Using food sensitivity tests

19:14 Testing for sensitivities and allergies

21:16 Food sensitivities and sweating

25:26 Talking about severe jaundice

27:59 Health effects of silver supplements

30:30 Closing and resources for listeners

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special emphasis on autoimmunity. Join us as Dr. Booth shares how discovering autoimmune markers in her own and her daughter’s bloodwork inspired a deep dive into strategies for managing and calming autoimmune conditions. We explore the evolution of her clinical approach, the challenges of educating and supporting patients, and the power of group care and community in fostering healing. 

Dr. Darla Booth, DC, AFMC specializes in helping patients with complex health issues identify their root cause, improve symptoms, and stack habits to optimize their health with functional medicine protocols. Her care complements the support patients receive through Western medicine; taking a big picture approach to health through lab work analysis, lifestyle adjustments, and nutritional support. Chiropractic and other conservative, natural care options for adults and children are Dr. Booth's specialties. She is skilled in nutritional counseling for food allergies, cranial therapy, TMJ treatment, and more.

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Discovering autoimmunity in bloodwork

03:56 Launching an autoimmune program

07:08 Starting group coaching sessions

11:56 Helping clients rebuild health

13:20 Addressing leaky gut in autoimmune

19:00 Understanding digestion and gut health

21:52 Creating a treatment plan

23:58 Small shifts for immune health

26:47 Prioritizing health and wellness choices

29:43 How food impacts your body

33:57 Functional medicine's credibility and impact

37:18 Using RUPA and Fullscript

39:48 Resources for practitioners and individuals

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

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