Primeadine Spermidine – The Powerful AntiAging compound you’ve never heard of but that is about to take the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti aging compounds to market. Today we deep dive into their first entry which is rooted in ancient knowledge and yet relatively new to the modern world. Consider that this compound hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its ability to improve immune response in elderly adults by helping certain areas of the immune system to reboot and rejuvenate!! Oxford Span is committed to making this supplement available to as many people as possible – for the month of December you can benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If you are this after December 2020 the discount code will still work!! Note that this supplement will produce most noticeable results in the 50+ crowd who are already seeing a decline in endogenous spermidine production and is not appropriate for people with celiac disease or severe wheat allergies – we talk about all this and more in the episode….enjoy!! 6:08 Leslie’s story – from autoimmune disease & infertility to how she first came across spermidine 7:22 The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine 11:05 Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine 13:30 Dietary sources and the reason why supplement companies are having to extract spermidine from wheat instead of Natto 15:30 Natto – possibly the best and most economical source of spermidine 17:33 Who should NOT use the current Spermidine supplements (including Primeadine) and why 18:02 Amount of gluten per serving vs a slice of 19:54 Why the 50+ crowd is likely to experience the best visible results from Primeadine 20:55

Endogenous and exogenous sources of spermidine 22:57 The physical signs that your spermidine production is declining 28:20 Short, medium and long term benefits 36:05 Maximum dose as determined by regulatory bodies 38:49 Getting back to the ancient Daoist Scrolls – the aging male’s advantage over women

45:29 Best time of day to take Primeadine 50:27 DO NOT mix with hot foods or beverages 52:25 Introductory pricing in place until December 31, 2020 15% discount code in place for December and the new year: BIONAT15 Website: Primeadine.com or OxfordHealthSpan.com

Just a few of the growing list of studies assessing Spermidine’s possible benefits for human and longevity Studies/References Effect on Hormones, Fertility in men and women The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open Journal of Endocrine and Metabolic Diseases, 9(03), 35 Spermidine Intake and Longevity in humans Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371-380 The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing and development, 134(7-8), 314-320.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582- 1584 Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011). Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLoS One, 6(7), e22564 Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double- blind study. Dermatology Practical & Conceptual, 7(4), 17. Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221, 117132 Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American journal of clinical nutrition, 102(2), 411-419

And finally an article on new findings of the effects of Spermidine on immune function is elderly humans: https://www.longevity.technology/autophagy-in-t-cells-maintained-by- spermidine/?utm_source=ZohoCampaigns

 

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.